Autoimmune disease

Our research focuses on the mechanisms by which cytoplasmic RNA sensors RIG-I like receptors (RLRs) distinguish between viral RNAs and self-RNAs and trigger type I IFNs. Current work examines spontaneous autoimmune symptoms in.RLR mutant mice derived via mutagenesis and how RLR-dysregulation causes autoimmune disease.

Viral recognition We are also particularly.interested in the analysis of immune responses and pathogenesis in virus infection in vivo and autoimmune diseases using.mouse models.