Aktuelle Publikationen von IKCKP

2019:

Acute Impact of Dietary Pattern and Walking on Postprandial Attention, Mood, and Satiety in Older Adults: A Randomized Crossover Trial. Diekmann C, Wagner M, Huber H, Preuß M, Preuß P, Predel HG, Stoffel-Wagner B, Fimmers R, Stehle P, Egert S Nutrients. 2019 Sep 26;11(10). pii: E2294. doi: 10.3390/nu11102294.

Health-related quality of life and neurocognitive functioning with lomustine-temozolomide versus temozolomide in patients with newly diagnosed, MGMT-methylated glioblastoma (CeTeG/NOA-09): a randomised, multicentre, open-label, phase 3 trial. Weller J, Tzaridis T, Mack F, Steinbach JP, Schlegel U, Hau P, Krex D, Grauer O, Goldbrunner R, Bähr O, Uhl M, Seidel C, Tabatabai G, Brehmer S, Bullinger L, Galldiks N, Schaub C, Kebir S, Stummer W, Simon M, Fimmers R, Coch C, Glas M, Herrlinger U, Schäfer N. Lancet Oncol. 2019 Sep 2. pii: S1470-2045(19)30502-9. doi: 10.1016/S1470-2045(19)30502-9. [Epub ahead of print]

Monozygotic Twins with Birth-Weight Differences: Metabolic Health Influenced more by Genetics or by Environment? Grunewald M, Schulte S, Bartmann P, Stoffel-Wagner B, Fimmers R, Woelfle J, Gohlke B. Horm Res Paediatr. 2019 Aug 14:1-9. doi: 10.1159/000501775. [Epub ahead of print]

Thyroid Function in Monozygotic Twins with Intra-twin Birth Weight Differences: A Prospective Longitudinal Cohort Study. Schulte S, Gohlke B, Schreiner F, Gruenewald M, Fimmers R, Stoffel-Wagner B, Bartmann P, Woelfle J. J Pediatr. 2019 Aug;211:164-171. doi: 10.1016/j.jpeds.2019.03.041.

Need to individualise cholesterol-lowering therapy. Lütjohann D, Weingärtner O, Heart 2019 Aug;105(16):1291-1292. doi: 10.1136/heartjnl-2019-315376.

Moderate Postmeal Walking Has No Beneficial Effects Over Resting on Postprandial Lipemia, Glycemia, Insulinemia, and Selected Oxidative and Inflammatory Parameters in Older Adults with a Cardiovascular Disease Risk Phenotype: A Randomized Crossover Trial. Diekmann C, Huber H, Preuß M, Preuß P, Predel HG, Stoffel-Wagner B, Fimmers R, Stehle P, Egert S, J Nutr. 2019 Jul 18. pii: nxz148. doi: 10.1093/jn/nxz148. [Epub ahead of print]

In vitro effects of sitosterol and sitostanol on mitochondrial respiration in human brown adipocytes, myotubes and hepatocytes. Nascimento EBM, Konings M, Schaart G, Groen AK, Lütjohann D, van Marken Lichtenbelt WD, Schrauwen P, Plat J, Eur J Nutr. 2019 Jul 17. doi: 10.1007/s00394-019-02052-y. [Epub ahead of print].

Frequent detection of Saffold cardiovirus in adenoids. Lindner K, Ludwig M, Bootz F, Reber U, Safavieh Z, Eis-Hübinger AM, Herberhold S, PLoS One. 2019 Jul 3;14(7):e0218873. doi: 10.1371/journal.pone.0218873.

Exome chip association study excluded the involvement of rare coding variants with large effect sizes in the etiology of anorectal malformations. van de Putte R, Wijers CHW, Reutter H, Vermeulen SH, Marcelis CLM, Brosens E, Broens PMA, Homberg M, Ludwig M, Jenetzky E, Zwink N, Sloots CEJ, de Klein A, Brooks AS, Hofstra RMW, Holsink SAC, van der Zanden LFM, Galesloot TE, Tam PK, Steehouwer M, Acuna-Hidalgo R, Vorst MV, Kiemeney LA, Garcia-Barceló MM, de Blaauw I, Brunner HG, Roeleveld N, van Rooij IALM. PLoS One. 2019 May 28;14:e0217477. doi: 10.1371/journal.pone.0217477. eCollection 2019.

Rare Variants in BNC2 Are Implicated in Autosomal-Dominant Congenital Lower Urinary-Tract Obstruction. Kolvenbach CM, Dworschak GC, Frese S, Japp AS, Schuster P, Wenzlitschke N, Yilmaz Ö, Lopes FM, Pryalukhin A, Schierbaum L, van der Zanden LFM, Kause F, Schneider R, Taranta-Janusz K, Szczepańska M, Pawlaczyk K, Newman WG, Beaman GM, Stuart HM, Cervellione RM, Feitz WFJ, van Rooij IALM, Schreuder MF, Steffens M, Weber S, Merz WM, Feldkötter M, Hoppe B, Thiele H, Altmüller J, Berg C, Kristiansen G, Ludwig M, Reutter H, Woolf AS, Hildebrandt F, Grote P, Zaniew M, Odermatt B, Hilger AC. Am J Hum Genet. 2019 May 2;104:994-1006. doi: 10.1016/j.ajhg.2019.03.023.

Besnoitia besnoiti infection alters both endogenous cholesterol de novo synthesis and exogenous LDL uptake in host endothelial cells. Silva LMR, Lütjohann D, Hamid P, Velasquez ZD, Kerner K, Larrazabal C, Failing K, Hermosilla C, Taubert A. Sci Rep. 2019 Apr 30;9:6650. doi: 10.1038/s41598-019-43153-2.

Low serum lathosterol levels associate with fatal cardiovascular disease and excess all-cause mortality: a prospective cohort study. Weingärtner O, Lütjohann D, Meyer S, Fuhrmann A, Cremers B, Seiler-Mußler S, Schött HF, Kerksiek A, Friedrichs S, Ulbricht U, Zawada A, Laufs U, Schulze PC, Scheller B, Fliser D, Böhm M, Sijbrands E, Heine GH. Clin Res Cardiol. 2019 Apr 4. doi: 10.1007/s00392-019-01474-2.

Direct RIG-I activation in human NK cells induces TRAIL-dependent cytotoxicity toward autologous melanoma cells. Daßler-Plenker J, Paschen A, Putschli B, Rattay S, Schmitz S, Goldeck M, Bartok E, Hartmann G, Coch C. Int J Cancer 2019 Apr 1;144(7):1645-1656. doi: 10.1002/ijc.31874. Epub 2019 Jan 9.

First international descriptive and interventional survey for cholesterol and non-cholesterol sterol determination by gas- and liquid-chromatography-Urgent need for harmonisation of analytical methods. Lütjohann D, Björkhem I, Friedrichs S, Kerksiek A, Lövgren-Sandblom A, Geilenkeuser WJ, Ahrends R, Andrade I, Ansorena D, Astiasarán I, Baila-Rueda L, Barriuso B, Becker S, Bretillon L, Browne RW, Caccia C, Ceglarek U, Cenarro A, Crick PJ, Fauler G, Garcia-Llatas G, Gray R, Griffiths WJ, Gylling H, Harding S, Helmschrodt C, Iuliano L, Janssen HG, Jones P, Kaipiainen L, Kannenberg F, Lagarda MJ, Leoni V, Lottenberg AM, MacKay DS, Matysik S, McDonald J, Menendez-Carreño M, Myrie SB, Sutti Nunes V, Ostlund RE, Polisecki E, Ramos F, Rideout TC, Schaefer EJ, Schmitz G, Wang Y, Zerbinati C, Diczfalusy U, Schött HF. J Steroid Biochem Mol Biol. 2019 Mar 30;190:115-125. doi: 10.1016/j.jsbmb.2019.03.025.

Human TLR8 Senses RNA From Plasmodium falciparum-Infected Red Blood Cells Which Is Uniquely Required for the IFN-γ Response in NK Cells. Coch C, Hommertgen B, Zillinger T, Daßler-Plenker J, Putschli B, Nastaly M, Kümmerer BM, Scheunemann JF, Schumak B, Specht S, Schlee M, Barchet W, Hoerauf A, Bartok E, Hartmann G. Front Immunol. 2019 Mar 27;10:371. doi: 10.3389/fimmu.2019.00371. eCollection 2019.

Dietary Sargassum fusiforme improves memory and reduces amyloid plaque load in an Alzheimer's disease mouse model. Bogie J, Hoeks C, Schepers M, Tiane A, Cuypers A, Leijten F, Chintapakorn Y, Suttiyut T, Pornpakakul S, Struik D, Kerksiek A, Liu HB, Hellings N, Martinez-Martinez P, Jonker JW, Dewachter I, Sijbrands E, Walter J, Hendriks J, Groen A, Staels B, Lütjohann D, Vanmierlo T, Mulder M. Sci Rep. 2019 Mar 20;9(1):4908. doi: 10.1038/s41598-019-41399-4.

HSPA6: A new autosomal recessive candidate gene for the VATER/VACTERL malformation spectrum. Kause F, Zhang R, Ludwig M, Schmiedeke E, Rissmann A, Thiele H, Altmueller J, Herms S, Hilger AC, Hildebrandt F, Reutter H. Birth Defects Res. 2019 Mar 18. doi: 10.1002/bdr2.1493.

The isoflavones genistein and daidzein increase hepatic concentration of thyroid hormones and affect cholesterol metabolism in middle-aged male rats. Šošić-Jurjević B, Lütjohann D, Renko K, Filipović B, Radulović N, Ajdžanović V, Trifunović S, Nestorović N, Živanović J, Manojlović Stojanoski M, Kӧhrle J, Milošević V. J Steroid Biochem Mol Biol. 2019 Mar 15;190:1-10. doi: 10.1016/j.jsbmb.2019.03.009.

The emerging concept of "individualized cholesterol-lowering therapy": A change in paradigm. Lütjohann D, Stellaard F, Mulder MT, Sijbrands EJG, Weingärtner O. Pharmacol Ther. 2019 Mar 12. pii: S0163-7258(19)30043-9. doi: 10.1016/j.pharmthera.2019.03.004.

Targeted Nanoparticle Delivery of Bifunctional RIG-I Agonists to Pancreatic Cancer. Zillinger T, Hartmann G. Mol Ther. 2019 Mar 6;27(3):491-492. doi: 10.1016/j.ymthe.2019.02.005. Epub 2019 Feb 20. 

Haematopoietic alterations in neonates with congenital diaphragmatic hernia receiving extracorporeal membrane oxygenation support. Dolscheid-Pommerich RC, Kreuzer A, Graeff I, Stoffel-Wagner B, Mueller A, Kipfmueller F. Ann Clin Biochem. 2019 Mar;56(2):247-252. doi: 10.1177/0004563218820052. Epub 2019 Feb 24.

Effect of transcutaneous vagus nerve stimulation on muscle activity in the gastrointestinal tract (transVaGa): a prospective clinical trial. Hong GS, Pintea B, Lingohr P, Coch C, Randau T, Schaefer N, Wehner S, Kalff JC, Pantelis D. Int J Colorectal Dis. 2019 Mar;34(3):417-422. doi: 10.1007/s00384-018-3204-6. Epub 2018 Dec 5.

Plant-based sterols and stanols in health & disease: "Consequences of human development in a plant-based environment?" Plat J, Baumgartner S, Vanmierlo T, Lütjohann D, Calkins KL, Burrin DG, Guthrie G, Thijs C, Te Velde AA, Vreugdenhil ACE, Sverdlov R, Garssen J, Wouters K, Trautwein EA, Wolfs TG, van Gorp C, Mulder MT, Riksen NP, Groen AK, Mensink RP. Prog Lipid Res. 2019 Feb 26;74:87-102. doi: 10.1016/j.plipres.2019.02.003.

Saliva molecular inflammatory profiling in female migraine patients responsive to adjunctive cervical non-invasive vagus nerve stimulation: the MOXY Study. Boström A, Scheele D, Stoffel-Wagner B, Hönig F, Chaudhry SR, Muhammad S, Hurlemann R, Krauss JK, Lendvai IS, Chakravarthy KV, Kinfe TM. J Transl Med. 2019 Feb 22;17(1):53. doi: 10.1186/s12967-019-1801-y.

Lomustine-temozolomide combination therapy versus standard temozolomide therapy in patients with newly diagnosed glioblastoma with methylated MGMT promoter (CeTeG/NOA-09): a randomised, open-label, phase 3 trial. Herrlinger U, Tzaridis T, Mack F, Steinbach JP, Schlegel U, Sabel M, Hau P, Kortmann RD, Krex D, Grauer O, Goldbrunner R, Schnell O, Bähr O, Uhl M, Seidel C, Tabatabai G, Kowalski T, Ringel F, Schmidt-Graf F, Suchorska B, Brehmer S, Weyerbrock A, Renovanz M, Bullinger L, Galldiks N, Vajkoczy P, Misch M, Vatter H, Stuplich M, Schäfer N, Kebir S, Weller J, Schaub C, Stummer W, Tonn JC, Simon M, Keil VC, Nelles M, Urbach H, Coenen M, Wick W, Weller M, Fimmers R, Schmid M, Hattingen E, Pietsch T, Coch C, Glas M; Neurooncology Working Group of the German Cancer Society. Lancet 2019 Feb 16;393(10172):678-688. doi: 10.1016/S0140-6736(18)31791-4. Epub 2019 Feb 14.

Impact of a Usual Serving Size of Flavanol-Rich Cocoa Powder Ingested with a Diabetic-Suitable Meal on Postprandial Cardiometabolic Parameters in Type 2 Diabetics-A Randomized, Placebo-Controlled, Double-Blind Crossover Study. Rynarzewski J, Dicks L, Zimmermann BF, Stoffel-Wagner B, Ludwig N, Helfrich HP, Ellinger S. Nutrients 2019 Feb 16;11(2). pii: E417. doi: 10.3390/nu11020417.

Trauma Disclosure Moderates the Effects of Oxytocin on Intrusions and Neural Responses to Fear. Scheele D, Lieberz J, Goertzen-Patin A, Engels C, Schneider L, Stoffel-Wagner B, Becker B, Hurlemann R. Psychother Psychosom. 2019;88(1):61-63. doi: 10.1159/000496056. Epub 2019 Jan 24.

Selective L4 Dorsal Root Ganglion Stimulation Evokes Pain Relief and Changes of Inflammatory Markers: Part I Profiling of Saliva and Serum Molecular Patterns. Gravius N, Chaudhry SR, Muhammad S, Boström A, Gravius S, Randau T, Scheele D, Westhofen P, Kruppenbacher J, Stoffel-Wagner B, Maier C, Weidlich A, Yearwood TL, Chakravarthy KV, Kramer JM, Hurlemann R, Kinfe TM. Neuromodulation 2019 Jan;22(1):44-52. doi: 10.1111/ner.12866. Epub 2018 Oct 25.

Oxytocin enhances the pain-relieving effects of social support in romantic couples. Kreuder AK, Wassermann L, Wollseifer M, Ditzen B, Eckstein M, Stoffel-Wagner B, Hennig J, Hurlemann R, Scheele D. Hum Brain Mapp. 2019 Jan;40(1):242-251. doi: 10.1002/hbm.24368. Epub 2018 Aug 28.

Oxytocin reduces a chemosensory-induced stress bias in social perception. Maier A, Scheele D, Spengler FB, Menba T, Mohr F, Güntürkün O, Stoffel-Wagner B, Kinfe TM, Maier W, Khalsa SS, Hurlemann R. Neuropsychopharmacology 2019 Jan;44(2):281-288. doi: 10.1038/s41386-018-0063-3. Epub 2018 Apr 12.

 

2018:

Towards a Central Role of ISL1in the Bladder Exstrophy-Epispadias Complex (BEEC): Computational Characterization of Genetic Variants and Structural Modelling. Sharma A, Dakal TC, Ludwig M, Fröhlich H, Mathur R, Reutter H. Genes (Basel). 2018 Dec 5;9(12). pii: E609. doi: 10.3390/genes9120609.

Plasma levels of the oxyphytosterol 7α-hydroxycampesterol are associated with cardiovascular events. Fuhrmann A, Weingärtner O, Meyer S, Cremers B, Seiler-Mußler S, Schött HF, Kerksiek A, Friedrichs S, Ulbricht U, Zawada AM, Laufs U, Scheller B, Fliser D, Schulze PC, Böhm M, Heine GH, Lütjohann D. Atherosclerosis 2018 Dec;279:17-22. doi: 10.1016/j.atherosclerosis.2018.10.010. Epub 2018 Oct 17.

BAX/BAK-Induced Apoptosis Results in Caspase-8-Dependent IL-1β Maturation in Macrophages. Chauhan D, Bartok E, Gaidt MM, Bock FJ, Herrmann J, Seeger JM, Broz P, Beckmann R, Kashkar H, Tait SWG, Müller R, Hornung V. Cell Rep. 2018 Nov 27;25(9):2354-2368.e5. doi: 10.1016/j.celrep.2018.10.087.

Hydroxypropyl-Beta-Cyclodextrin Reduces Inflammatory Signaling from Monocytes: Possible Implications for Suppression of HIV Chronic Immune Activation. Matassoli FL, Leão IC, Bezerra BB, Pollard RB, Lütjohann D, Hildreth JEK, Arruda LB. mSphere 2018 Nov 7;3(6). pii: e00497-18. doi: 10.1128/mSphere.00497-18.

ATG16L1 orchestrates interleukin-22 signaling in the intestinal epithelium via cGAS-STING. Aden K, Tran F, Ito G, Sheibani-Tezerji R, Lipinski S, Kuiper JW, Tschurtschenthaler M, Saveljeva S, Bhattacharyya J, Häsler R, Bartsch K, Luzius A, Jentzsch M, Falk-Paulsen M, Stengel ST, Welz L, Schwarzer R, Rabe B, Barchet W, Krautwald S, Hartmann G, Pasparakis M, Blumberg RS, Schreiber S, Kaser A, Rosenstiel P. J Exp Med. 2018 Nov 5;215(11):2868-2886. doi: 10.1084/jem.20171029. Epub 2018 Sep 25.

Bi-allelic Mutations in LSS, Encoding Lanosterol Synthase, Cause Autosomal-Recessive Hypotrichosis Simplex. Romano MT, Tafazzoli A, Mattern M, Sivalingam S, Wolf S, Rupp A, Thiele H, Altmüller J, Nürnberg P, Ellwanger J, Gambon R, Baumer A, Kohlschmidt N, Metze D, Holdenrieder S, Paus R, Lütjohann D, Frank J, Geyer M, Bertolini M, Kokordelis P, Betz RC. Am J Hum Genet. 2018 Nov 1;103(5):777-785. doi: 10.1016/j.ajhg.2018.09.011. Epub 2018 Oct 25.

Call for an ezetimibe effectiveness test. Lütjohann D, Laufs U, Schulze PC, Weingärtner O. Atherosclerosis 2018 Nov;278:334. doi: 10.1016/j.atherosclerosis.2018.08.028. Epub 2018 Aug 26.

Estimation of GFR in children using rescaled beta-trace protein. den Bakker E, Gemke R, Pottel H, van Wijk JAE, Hubeek I, Stoffel-Wagner B, Bökenkamp A. Clin Chim Acta. 2018 Nov;486:259-264. doi: 10.1016/j.cca.2018.08.021. Epub 2018 Aug 16.

Systemic High-Mobility Group Box-1: A Novel Predictive Biomarker for Cerebral Vasospasm in Aneurysmal Subarachnoid Hemorrhage. Chaudhry SR, Güresir A, Stoffel-Wagner B, Fimmers R, Kinfe TM, Dietrich D, Lamprecht A, Vatter H, Güresir E, Muhammad S. Crit Care Med. 2018 Nov;46(11):e1023-e1028. doi: 10.1097/CCM.0000000000003319.

Activation of the NLRP3 Inflammasome by Hyaboron, a New Asymmetric Boron-Containing Macrodiolide from the Myxobacterium Hyalangium minutum. Surup F, Chauhan D, Niggemann J, Bartok E, Herrmann J, Keck M, Zander W, Stadler M, Hornung V, Müller R. ACS Chem Biol. 2018 Oct 19;13(10):2981-2988. doi: 10.1021/acschembio.8b00659. Epub 2018 Sep 17.

Progress and perspectives in plant sterol and plant stanol research. Jones PJH, Shamloo M, MacKay DS, Rideout TC, Myrie SB, Plat J, Roullet JB, Baer DJ, Calkins KL, Davis HR, Barton Duell P, Ginsberg H, Gylling H, Jenkins D, Lütjohann D, Moghadasian M, Moreau RA, Mymin D, Ostlund RE Jr, Ras RT, Ochoa Reparaz J, Trautwein EA, Turley S, Vanmierlo T, Weingärtner O. Nutr Rev. 2018 Oct 1;76(10):725-746. doi: 10.1093/nutrit/nuy032.

International descriptive and interventional survey for oxycholesterol determination by gas- and liquid-chromatographic methods. Lütjohann D, Björkhem I, Friedrichs S, Kerksiek A, Geilenkeuser WJ, Lövgren-Sandblom A, Ansorena D, Astiasarán I, Baila-Rueda L, Barriuso B, Bretillon L, Browne RW, Caccia C, Cenarro A, Crick PJ, Fauler G, García-Llatas G, Griffiths WJ, Iuliano L, Lagarda MJ, Leoni V, Lottenberg AM, Matysik S, McDonald J, Rideout TC, Schmitz G, Nunes VS, Wang Y, Zerbinati C, Diczfalusy U, Schött HF. Biochimie 2018 Oct;153:26-32. doi: 10.1016/j.biochi.2018.07.016. Epub 2018 Jul 29.

Combining GFR estimates from cystatin C and creatinine-what is the optimal mix? den Bakker E, Gemke R, van Wijk JAE, Hubeek I, Stoffel-Wagner B, Bökenkamp A. Pediatr Nephrol. 2018 Sep;33(9):1553-1563. doi: 10.1007/s00467-018-3973-8. Epub 2018 May 17.

A Novel Function for 15-Lipoxygenases in Cholesterol Homeostasis and CCL17 Production in Human Macrophages. Snodgrass RG, Zezina E, Namgaladze D, Gupta S, Angioni C, Geisslinger G, Lütjohann D, Brüne B. Front Immunol. 2018 Aug 24;9:1906. doi: 10.3389/fimmu.2018.01906. eCollection 2018.                                               

Modulation of cholesterol-related sterols during Eimeria bovis macromeront formation and impact of selected oxysterols on parasite development. Taubert A, Silva LMR, Velásquez ZD, Larrazabal C, Lütjohann D, Hermosilla C. Mol Biochem Parasitol. 2018 Jul;223:1-12. doi: 10.1016/j.molbiopara.2018.06.002. Epub 2018 Jun 15.

Innate lymphoid cells-key immune integrators of overall body homeostasis. Karagiannis F, Wilhelm C. Semin Immunopathol. 2018 Jul;40(4):319-330. doi: 10.1007/s00281-018-0684-y. Epub 2018 Jun 4.

Cardiovascular magnetic resonance assessment of acute cardiovascular effects of voluntary apnoea in elite divers. Eichhorn L, Doerner J, Luetkens JA, Lunkenheimer JM, Dolscheid-Pommerich RC, Erdfelder F, Fimmers R, Nadal J, Stoffel-Wagner B, Schild HH, Hoeft A, Zur B, Naehle CP. J Cardiovasc Magn Reson. 2018 Jun 18;20(1):40. doi: 10.1186/s12968-018-0455-x.

SOCS1 and SOCS3 Target IRF7 Degradation To Suppress TLR7-Mediated Type I IFN Production of Human Plasmacytoid Dendritic Cells. Yu CF, Peng WM, Schlee M, Barchet W, Eis-Hübinger AM, Kolanus W, Geyer M, Schmitt S, Steinhagen F, Oldenburg J, Novak N. J Immunol. 2018 Jun 15;200(12):4024-4035. doi: 10.4049/jimmunol.1700510. Epub 2018 Apr 30.

A nutritive dose of pure (-)-epicatechin does not beneficially affect increased cardiometabolic risk factors in overweight-to-obese adults-a randomized, placebo-controlled, double-blind crossover study. Kirch N, Berk L, Liegl Y, Adelsbach M, Zimmermann BF, Stehle P, Stoffel-Wagner B, Ludwig N, Schieber A, Helfrich HP, Ellinger S. Am J Clin Nutr. 2018 Jun 1;107(6):948-956. doi: 10.1093/ajcn/nqy066.

Elevated levels of 2-arachidonoylglycerol promote atherogenesis in ApoE-/- mice. Jehle J, Schöne B, Bagheri S, Avraamidou E, Danisch M, Frank I, Pfeifer P, Bindila L, Lutz B, Lütjohann D, Zimmer A, Nickenig G. PLoS One 2018 May 29;13(5):e0197751. doi: 10.1371/journal.pone.0197751. eCollection 2018.

Improved sensitivity for detection of breast cancer by combination of miR-34a and tumor markers CA 15-3 or CEA. Zaleski M, Kobilay M, Schroeder L, Debald M, Semaan A, Hettwer K, Uhlig S, Kuhn W, Hartmann G, Holdenrieder S. Oncotarget 2018 Apr 27;9(32):22523-22536. doi: 10.18632/oncotarget.25077. eCollection 2018 Apr 27.

A classic twin study of lower urinary tract obstruction: Report of 3 cases and literature review. Frese S, Weigert A, Hoppe B, Feldkötter M, Ludwig M, Weber S, Kiliś-Pstrusińska K, Zaniew M, Reutter H, Hilger AC. Low Urin Tract Symptoms 2018 Apr 17. doi: 10.1111/luts.12222.

Exome sequencing in syndromic brain malformations identifies novel mutations in ACTB, and SLC9A6, and suggests BAZ1A as a new candidate gene. Weitensteiner V, Zhang R, Bungenberg J, Marks M, Gehlen J, Ralser DJ, Hilger AC, Sharma A, Schumacher J, Gembruch U, Merz WM, Becker A, Altmüller J, Thiele H, Herrmann BG, Odermatt B, Ludwig M, Reutter H. Birth Defects Res. 2018 Apr 17;110(7):587-597. doi: 10.1002/bdr2.1200. Epub 2018 Feb 1.

Identification of Correlative Shifts in Indices of Brain Cholesterol Metabolism in the C57BL6/Mecp2tm1.1Bird Mouse, a Model for Rett Syndrome. Lütjohann D, Lopez AM, Chuang JC, Kerksiek A, Turley SD. Lipids 2018 Apr;53(4):363-373. doi: 10.1002/lipd.12041. Epub 2018 May 17.

Limited daily feeding and intermittent feeding have different effects on regional brain energy homeostasis during aging. Smiljanic K, Todorovic S, Mladenovic Djordjevic A, Vanmierlo T, Lütjohann D, Ivkovic S, Kanazir S. Biogerontology 2018 Apr;19(2):121-132. doi: 10.1007/s10522-018-9743-y. Epub 2018 Jan 16.

Suppressive oligodeoxynucleotides containing TTAGGG motifs inhibit cGAS activation in human monocytes. Steinhagen F, Zillinger T, Peukert K, Fox M, Thudium M, Barchet W, Putensen C, Klinman D, Latz E, Bode C. Eur J Immunol. 2018 Apr;48(4):605-611. doi: 10.1002/eji.201747338. Epub 2017 Dec 27.

Structural Alterations of MET Trigger Response to MET Kinase Inhibition in Lung Adenocarcinoma Patients. Plenker D, Bertrand M, de Langen AJ, Riedel R, Lorenz C, Scheel AH, Müller J, Brägelmann J, Daßler-Plenker J, Kobe C, Persigehl T, Kluge A, Wurdinger T, Schellen P, Hartmann G, Zacherle T, Menon R, Thunnissen E, Büttner R, Griesinger F, Wolf J, Heukamp L, Sos ML, Heuckmann JM. Clin Cancer Res. 2018 Mar 15;24(6):1337-1343. doi: 10.1158/1078-0432.CCR-17-3001. Epub 2017 Dec 28.

Cholesterol Absorption and Synthesis in Vegetarians and Omnivores. Lütjohann D, Meyer S, von Bergmann K, Stellaard F. Mol Nutr Food Res. 2018 Mar;62(6):e1700689. doi: 10.1002/mnfr.201700689. Epub 2018 Feb 23.

Defective cholesterol clearance limits remyelination in the aged central nervous system. Cantuti-Castelvetri L, Fitzner D, Bosch-Queralt M, Weil MT, Su M, Sen P, Ruhwedel T, Mitkovski M, Trendelenburg G, Lütjohann D, Möbius W, Simons M. Science 2018 Feb 9;359(6376):684-688. doi: 10.1126/science.aan4183. Epub 2018 Jan 4.

Whole exome sequencing identifies a mutation in EYA1 and GLI3 in a patient with branchio‑otic syndrome and esophageal atresia: Coincidence or a digenic mode of inheritance? Kause F, Reutter H, Marsch F, Thiele H, Altmüller J, Ludwig M, Zhang R. Mol Med Rep. 2018 Feb;17(2):3200-3205. doi: 10.3892/mmr.2017.8196. Epub 2017 Dec 6.

Influence of Chitosan Treatment on Surrogate Serum Markers of Cholesterol Metabolism in Obese Subjects. Lütjohann D, Marinova M, Wolter K, Willinek W, Bitterlich N, Coenen M, Coch C, Stellaard F. Nutrients 2018 Jan 11;10(1). pii: E72. doi: 10.3390/nu10010072.

Can genetic testing guide the therapy of cholestatic pruritus? A case of benign recurrent intrahepatic cholestasis type 2 with severe nasobiliary drainage-refractory itch. Holz R, Kremer AE, Lütjohann D, Wasmuth HE, Lammert F, Krawczyk M. Hepatol Commun. 2018 Jan 10;2(2):152-154. doi: 10.1002/hep4.1144. eCollection 2018 Feb.

Thrombolysis in stroke patients: Comparability of point-of-care versus central laboratory international normalized ratio. Dolscheid-Pommerich RC, Dolscheid S, Eichhorn L, Stoffel-Wagner B, Graeff I. PLoS One 2018 Jan 10;13(1):e0190867. doi: 10.1371/journal.pone.0190867. eCollection 2018.

Long-term renal outcome in children with OCRL mutations: retrospective analysis of a large international cohort. Zaniew M, Bökenkamp A, Kolbuc M, La Scola C, Baronio F, Niemirska A, Szczepanska M, Bürger J, La Manna A, Miklaszewska M, Rogowska-Kalisz A, Gellermann J, Zampetoglou A, Wasilewska A, Roszak M, Moczko J, Krzemien A, Runowski D, Siten G, Zaluska-Lesniewska I, Fonduli P, Zurrida F, Paglialonga F, Gucev Z, Paripovic D, Rus R, Said-Conti V, Sartz L, Chung WY, Park SJ, Lee JW, Park YH, Ahn YH, Sikora P, Stefanidis CJ, Tasic V, Konrad M, Anglani F, Addis M, Cheong HI, Ludwig M, Bockenhauer D. Nephrol Dial Transplant. 2018 Jan 1;33(1):85-94. doi: 10.1093/ndt/gfw350.

Rescue of T-cell function during persistent pulmonary adenoviral infection by Toll-like receptor 9 activation. Holland T, Wohlleber D, Marx S, Kreutzberg T, Vento-Asturias S, Schmitt-Mbamunyo C, Welz M, Janas M, Komander K, Eickhoff S, Brewitz A, Hasenberg M, Männ L, Gunzer M, Wilhelm C, Kastenmüller W, Knolle P, Abdullah Z, Kurts C, Garbi N. J Allergy Clin Immunol. 2018 Jan;141(1):416-419.e10. doi: 10.1016/j.jaci.2017.06.048. Epub 2017 Aug 19.

Low maternal folate concentrations and maternal MTHFR C677T polymorphism are associated with an increased risk for neural tube defects in offspring: a case-control study among Pakistani case and control mothers. Nauman N, Jalali S, Shami S, Rafiq S, Große G, Hilger AC, Zhang R, Mansoor S, Ludwig M, Reutter H. Asia Pac J Clin Nutr. 2018;27(1):253-260. doi: 10.6133/apjcn.032017.10.

 

2017:

Time Courses of Inflammatory Markers after Aneurysmal Subarachnoid Hemorrhage and Their Possible Relevance for Future Studies. Höllig A, Stoffel-Wagner B, Clusmann H, Veldeman M, Schubert GA, Coburn M. Front Neurol. 2017 Dec 22;8:694. doi: 10.3389/fneur.2017.00694. eCollection 2017.

Type I interferon-mediated autoinflammation due to DNase II deficiency. Rodero MP, Tesser A, Bartok E, Rice GI, Della Mina E, Depp M, Beitz B, Bondet V, Cagnard N, Duffy D, Dussiot M, Frémond ML, Gattorno M, Guillem F, Kitabayashi N, Porcheray F, Rieux-Laucat F, Seabra L, Uggenti C, Volpi S, Zeef LAH, Alyanakian MA, Beltrand J, Bianco AM, Boddaert N, Brouzes C, Candon S, Caorsi R, Charbit M, Fabre M, Faletra F, Girard M, Harroche A, Hartmann E, Lasne D, Marcuzzi A, Neven B, Nitschke P, Pascreau T, Pastore S, Picard C, Picco P, Piscianz E, Polak M, Quartier P, Rabant M, Stocco G, Taddio A, Uettwiller F, Valencic E, Vozzi D, Hartmann G, Barchet W, Hermine O, Bader-Meunier B, Tommasini A, Crow YJ. Nat Commun. 2017 Dec 19;8(1):2176. doi: 10.1038/s41467-017-01932-3.

Metabolic Regulation of Innate Lymphoid Cell-Mediated Tissue Protection-Linking the Nutritional State to Barrier Immunity. Wilhelm C, Kharabi Masouleh S, Kazakov A. Front Immunol. 2017 Dec 7;8:1742. doi: 10.3389/fimmu.2017.01742. eCollection 2017.

Elevated Systemic IL-6 Levels in Patients with Aneurysmal Subarachnoid Hemorrhage Is an Unspecific Marker for Post-SAH Complications. Chaudhry SR, Stoffel-Wagner B, Kinfe TM, Güresir E, Vatter H, Dietrich D, Lamprecht A, Muhammad S. Int J Mol Sci. 2017 Dec 1;18(12). pii: E2580. doi: 10.3390/ijms18122580.

Analysis of integrated clinical trial protocols in early phases of medicinal product development. Fruhner K, Hartmann G, Sudhop T. Eur J Clin Pharmacol. 2017 Dec;73(12):1565-1577. doi: 10.1007/s00228-017-2335-y. Epub 2017 Sep 18.

Doxorubicin enhances oxysterol levels resulting in a LXR-mediated upregulation of cardiac cholesterol transporters. Monzel JV, Budde T, Meyer Zu Schwabedissen HE, Schwebe M, Bien-Möller S, Lütjohann D, Kroemer HK, Jedlitschky G, Grube M. Biochem Pharmacol. 2017 Nov 15;144:108-119. doi: 10.1016/j.bcp.2017.08.008. Epub 2017 Aug 12.

The effects of vitamin E or lipoic acid supplementation on oxyphytosterols in subjects with elevated oxidative stress: a randomized trial. Baumgartner S, Mensink RP, Haenen GR, Bast A, Binder CJ, Bekers O, Husche C, Lütjohann D, Plat J. Sci Rep. 2017 Nov 10;7(1):15288. doi: 10.1038/s41598-017-15615-y.

Accurate eGFR reporting for children without anthropometric data. den Bakker E, Gemke R, van Wijk JAE, Hubeek I, Stoffel-Wagner B, Grubb A, Bökenkamp A. Clin Chim Acta. 2017 Nov;474:38-43. doi: 10.1016/j.cca.2017.09.004. Epub 2017 Sep 6.

Dent disease in Poland: what we have learned so far? Zaniew M, Mizerska-Wasiak M, Załuska-Leśniewska I, Adamczyk P, Kiliś-Pstrusińska K, Haliński A, Zawadzki J, Lipska-Ziętkiewicz BS, Pawlaczyk K, Sikora P, Ludwig M, Szczepańska M. Int Urol Nephrol. 2017 Nov;49(11):2005-2017. doi: 10.1007/s11255-017-1676-x. Epub 2017 Aug 16.

Targeted Resequencing of Putative Growth-Related Genes Using Whole Exome Sequencing in Patients with Severe Primary IGF-I Deficiency. Grosse G, Hilger A, Ludwig M, Reutter H, Lorenzen F, Even G, Holterhus PM, Woelfle J; German GHI Study Group. Horm Res Paediatr. 2017;88(6):408-417. doi: 10.1159/000480505. Epub 2017 Oct 26.

Reactive Neutrophil Responses Dependent on the Receptor Tyrosine Kinase c-MET Limit Cancer Immunotherapy. Glodde N, Bald T, van den Boorn-Konijnenberg D, Nakamura K, O'Donnell JS, Szczepanski S, Brandes M, Eickhoff S, Das I, Shridhar N, Hinze D, Rogava M, van der Sluis TC, Ruotsalainen JJ, Gaffal E, Landsberg J, Ludwig KU, Wilhelm C, Riek-Burchardt M, Müller AJ, Gebhardt C, Scolyer RA, Long GV, Janzen V, Teng MWL, Kastenmüller W, Mazzone M, Smyth MJ, Tüting T, Hölzel M. Immunity 2017 Oct 17;47(4):789-802.e9. doi: 10.1016/j.immuni.2017.09.012.

Blood-derived macrophages prone to accumulate lysosomal lipids trigger oxLDL-dependent murine hepatic inflammation. Houben T, Oligschlaeger Y, Bitorina AV, Hendrikx T, Walenbergh SMA, Lenders MH, Gijbels MJJ, Verheyen F, Lütjohann D, Hofker MH, Binder CJ, Shiri-Sverdlov R. Sci Rep. 2017 Oct 2;7(1):12550. doi: 10.1038/s41598-017-13058-z.

Clinical performance of LOCI™-based tumor marker assays for tumor markers CA 15-3, CA 125, CEA, CA 19-9 and AFP in gynecological cancers. Dolscheid-Pommerich RC, Keyver-Paik M, Hecking T, Kuhn W, Hartmann G, Stoffel-Wagner B, Holdenrieder S. Tumour Biol. 2017 Oct;39(10):1010428317730246. doi: 10.1177/1010428317730246.               

Proteinuria in Dent disease: a review of the literature. van Berkel Y, Ludwig M, van Wijk JAE, Bökenkamp A. Pediatr Nephrol. 2017 Oct;32(10):1851-1859. doi: 10.1007/s00467-016-3499-x. Epub 2016 Oct 18.

The effects of amoxicillin and vancomycin on parameters reflecting cholesterol metabolism. Baumgartner S, Reijnders D, Konings MCJM, Groen AK, Lütjohann D, Goossens GH, Blaak EE, Plat J. Chem Phys Lipids 2017 Oct;207(Pt B):239-245. doi: 10.1016/j.chemphyslip.2017.06.006. Epub 2017 Jun 21.

Thermal stability of plant sterols and formation of their oxidation products in vegetable oils and margarines upon controlled heating. Lin Y, Knol D, Valk I, van Andel V, Friedrichs S, Lütjohann D, Hrncirik K, Trautwein EA. Chem Phys Lipids 2017 Oct;207(Pt B):99-107. doi: 10.1016/j.chemphyslip.2017.01.007. Epub 2017 Feb 2.

No effects of quercetin from onion skin extract on serum leptin and adiponectin concentrations in overweight-to-obese patients with (pre-)hypertension: a randomized double-blinded, placebo-controlled crossover trial. Brüll V, Burak C, Stoffel-Wagner B, Wolffram S, Nickenig G, Müller C, Langguth P, Alteheld B, Fimmers R, Stehle P, Egert S. Eur J Nutr. 2017 Oct;56(7):2265-2275. doi: 10.1007/s00394-016-1267-0. Epub 2016 Jul 16.

More Is Less: IL-9 in the Resolution of Inflammation. Karagiannis F, Wilhelm C. Immunity 2017 Sep 19;47(3):403-405. doi: 10.1016/j.immuni.2017.09.004.

RIG-I Activation Protects and Rescues from Lethal Influenza Virus Infection and Bacterial Superinfection. Coch C, Stümpel JP, Lilien-Waldau V, Wohlleber D, Kümmerer BM, Bekeredjian-Ding I, Kochs G, Garbi N, Herberhold S, Schuberth-Wagner C, Ludwig J, Barchet W, Schlee M, Hoerauf A, Bootz F, Staeheli P, Hartmann G, Hartmann E. Mol Ther. 2017 Sep 6;25(9):2093-2103. doi: 10.1016/j.ymthe.2017.07.003. Epub 2017 Jul 8.

Deuterium-reinforced polyunsaturated fatty acids protect against atherosclerosis by lowering lipid peroxidation and hypercholesterolemia. Berbée JFP, Mol IM, Milne GL, Pollock E, Hoeke G, Lütjohann D, Monaco C, Rensen PCN, van der Ploeg LHT, Shchepinov MS. Atherosclerosis 2017 Sep;264:100-107. doi: 10.1016/j.atherosclerosis.2017.06.916. Epub 2017 Jun 21.

How the brain codes intimacy: The neurobiological substrates of romantic touch. Kreuder AK, Scheele D, Wassermann L, Wollseifer M, Stoffel-Wagner B, Lee MR, Hennig J, Maier W, Hurlemann R. Hum Brain Mapp. 2017 Sep;38(9):4525-4534. doi: 10.1002/hbm.23679. Epub 2017 Jun 5.

Role of the LF-SINE-Derived Distal ISL1 Enhancer in Patients with Classic Bladder Exstrophy. Zhang R, Knapp M, Kause F, Reutter H, Ludwig M. J Pediatr Genet. 2017 Sep;6(3):169-173. doi: 10.1055/s-0037-1602387. Epub 2017 Apr 21.

Stand 01.10.19