Aktuelle Publikationen von IKCKP

2021:

No effects of PCSK9-inhibitor treatment on spatial learning, locomotor activity, and novel object recognition in mice. Schlunk F, Fischer P, Princen HMG, Rex A, Prinz V, Foddis M, Lütjohann D, Laufs U, Endres M Behav Brain Res. 2021 Jan 1;396:112875. doi: 10.1016/j.bbr.2020.112875.

 

2020:

Infection fatality rate of SARS-CoV2 in a super-spreading event in Germany. Streeck H, Schulte B, Kümmerer BM, Richter E, Höller T, Fuhrmann C, Bartok E, Dolscheid-Pommerich R, Berger M, Wessendorf L, Eschbach-Bludau M, Kellings A, Schwaiger A, Coenen M, Hoffmann P, Stoffel-Wagner B, Nöthen MM, Eis-Hübinger AM, Exner M, Schmithausen RM, Schmid M, Hartmann G Nat. Commun. 2020 Nov 17;11:5829. doi: 10.1038/s41467-020-19509-y.

Serum 4β-hydroxycholesterol increases during fluconazole treatment. Lütjohann D, Stellaard F, Kerksiek A, Lötsch J, Oertel BG Eur J Clin Pharmacol. 2020 Nov 17. doi: 10.1007/s00228-020-03041-5.

Efferocytosis potentiates the expression of arachidonate 15-lipoxygenase (ALOX15) in alternatively activated human macrophages through LXR activation. Snodgrass RG, Benatzy Y, Schmid T, Namgaladze D, Mainka M, Schebb NH, Lütjohann D, Brüne B Cell Death Differ. 2020 Nov 11. doi: 10.1038/s41418-020-00652-4.

Cholesterol metabolites and plant sterols in cerebrospinal fluid are associated with Alzheimer´s cerebral pathology and clinical disease progression. Jahn T, Clark C, Kerksiek A, Lewczuk P, Lütjohann D, Popp J J Steroid Biochem Mol Biol. 2020 Nov 7:105785. doi: 10.1016/j.jsbmb.2020.105785.

Effect of DL-Methionine Supplementation on Tissue and Plasma Antioxidant Status and Concentrations of Oxidation Products of Cholesterol and Phytosterols in Heat-Processed Thigh Muscle of Broilers. Zeitz JO, Ehbrecht T, Fleischmann A, Most E, Gessner DK, Friedrichs S, Sparenberg M, Failing K, Whelan R, Lütjohann D, Eder K Animals (Basel). 2020 Nov 5;10(11):E2050. doi: 10.3390/ani10112050.

Effects of Inhibition or Deletion of PCSK9 (Proprotein Convertase Subtilisin/Kexin Type 9) on Intracerebral Hemorrhage Volumes in Mice. Schlunk F, Fischer P, Princen HMG, Rex A, Prinz V, Foddis M, Lütjohann D, Laufs U, Endres M Stroke. 2020 Nov;51(11):e297-e298. doi: 10.1161/STROKEAHA.120.030087.

Impact of a Gap Junction Protein Alpha 4 Variant on Clinical Disease Phenotype in F508del Homozygous Patients With Cystic Fibrosis. Horn T, Ludwig M, Eickmeier O, Neerinex AH, Maitland-van der Zee AH, Smaczny C, Wagner TOF, Schubert R, Zielen S, Majoor C, Bos LD, Schmitt-Grohé S Front Genet. 2020 Oct 28;11:570403. doi: 10.3389/fgene.2020.570403.

Influence of Prenatal Environment on Androgen Steroid Metabolism In Monozygotic Twins With Birthweight Differences. Schulte S, Schreiner F, Plamper M, Kasner C, Gruenewald M, Bartmann P, Fimmers R, Hartmann MF, Wudy SA, Stoffel-Wagner B, Woelfle J, Gohlke B J Clin Endocrinol Metab. 2020 Oct 1;105(10):dgaa480. doi: 10.1210/clinem/dgaa480.

Analysis of Serum miRNA in Glioblastoma Patients: CD44-Based Enrichment of Extracellular Vesicles Enhances Specificity for the Prognostic Signature. Tzaridis T, Reiners KS, Weller J, Bachurski D, Schäfer N, Schaub C, Hallek M, Scheffler B, Glas M, Herrlinger U, Wild S, Coch C, Hartmann G Int. J. Mol. Sci. 2020 Sep 29;21(19):7211. doi: 10.3390/ijms21197211.

A continuous responder algorithm to optimize clinical management of small-cell lung cancer with progastrin-releasing peptide as a simple blood test. Muley T, Zhang X, Holdenrieder S, Korse CM, Zhi XY, Molina R, Liu Z, Hartmann G, van den Heuvel MM, Qian K, Marrades R, Engel C, He Y, Wehnl B, Dayyani F, Herth F Tumour Biol. 2020 Sep;42(9):1010428320958603. doi: 10.1177/1010428320958603.

The coffee ingredients caffeic acid and caffeic acid phenylethyl ester protect against irinotecan-induced leukopenia and oxidative stress response. Kalthoff S, Paulusch S, Rupp A, Holdenrieder S, Hartmann G, Strassburg CP Br J Pharmacol. 2020 Sep;177(18):4193-4208. doi: 10.1111/bph.15162.

Diverse enzymatic activities mediate antiviral immunity in prokaryotes. Gao L, Altae-Tran H, Böhning F, Makarova KS, Segel M, Schmid-Burgk JL, Koob J, Wolf YI, Koonin EV, Zhang F Science. 2020 Aug 28;369(6507):1077-1084. doi: 10.1126/science.aba0372.

Testosterone serum levels are not predictive of maternal virilization in hyperreactio luteinalis. Condic M, Merz WM, Gembruch U, Klingmüller D, Stoffel-Wagner B, Dolscheid-Pommerich R Arch Gynecol Obstet. 2020 Aug 19. doi: 10.1007/s00404-020-05745-6.

Hematologic changes after short term hypoxia in non-elite apnea divers under voluntary dry apnea conditions. Dolscheid-Pommerich RC, Stoffel-Wagner B, Alberts J, Fimmers R, Eichhorn L PLoS One. 2020 Aug 13;15(8):e0237673. doi: 10.1371/journal.pone.0237673.

Absence of cGAS-mediated type I IFN responses in HIV-1-infected T cells. Elsner C, Ponnurangam A, Kazmierski J, Zillinger T, Jansen J, Todt D, Döhner K, Xu S, Ducroux A, Kriedemann N, Malassa A, Larsen PK, Hartmann G, Barchet W, Steinmann E, Kalinke U, Sodeik B, Goffinet C Proc. Natl. Acad. U.S.A. 2020 Aug 11;117(32):19475-19486. doi: 10.1073/pnas.2002481117.

SLC20A1 Is Involved in Urinary Tract and Urorectal Development. Rieke JM, Zhang R, Braun D, Yilmaz Ö, Japp AS, Lopes FM, Pleschka M, Hilger AC, Schneider S, Newman WG, Beaman GM, Nordenskjöld A, Ebert AK, Promm M, Rösch WH, Stein R, Hirsch K, Schäfer FM, Schmiedeke E, Boemers TM, Lacher M, Kluth D, Gosemann JH, Anderberg M, Barker G, Holmdahl G, Läckgren G, Keene D, Cervellione RM, Giorgio E, Di Grazia M, Feitz WFJ, Marcelis CLM, Van Rooij IALM, Bökenkamp A, Beckers GMA, Keegan CE, Sharma A, Dakal TC, Wittler L, Grote P, Zwink N, Jenetzky E, Brusco A, Thiele H, Ludwig M, Schweizer U, Woolf AS, Odermatt B, Reutter H Front Cell Dev Biol. 2020 Aug 7;8:567. doi: 10.3389/fcell.2020.00567.

Targeting the innate immunoreceptor RIG-I overcomes melanoma-intrinsic resistance to T cell immunotherapy. Such L, Zhao F, Liu D, Thier B, Le-Trilling VTK, Sucker A, Coch C, Pieper N, Howe S, Bhat H, Kalkavan H, Ritter C, Brinkhaus R, Ugurel S, Köster J, Seifert U, Dittmer U, Schuler M, Lang KS, Kufer TA, Hartmann G, Becker JC, Horn S, Ferrone S, Liu D, Van Allen EM, Schadendorf D, Griewank K, Trilling M, Paschen A J Clin Invest. 2020 Aug 3;130(8):4266-4281. doi: 10.1172/JCI131572.

Sex-opposed inflammatory effects of 27-hydroxycholesterol are mediated via differences in estrogen signaling. Houben T, Bitorina AV, Oligschlaeger Y, Jeurissen ML, Rensen S, Köhler SE, Westerterp M, Lütjohann D, Theys J, Romano A, Plat J, Shiri-Sverdlov R J Pathol. 2020 Aug;251(4):429-439. doi: 10.1002/path.5477.

It's time to personalize and optimize lipid-lowering therapy. Weingärtner O, Patel SB, Lütjohann D Eur Heart J. 2020 Jul 21;41(28):2629-2631. doi: 10.1093/eurheartj/ehaa445.

Immune Sensing Mechanisms that Discriminate Self from Altered Self and Foreign Nucleic Acids. Bartok E, Hartmann G Immunity. 2020 Jul 14;53(1):54-77. doi: 10.1016/j.immuni.2020.06.014.

LAMP-Seq: Population-Scale COVID-19 Diagnostics Using Combinatorial Barcoding. Schmid-Burgk JL,  Schmithausen RM, Li D, Hollstein R, Ben-Shmuel A, Israeli O, Weiss S, Paran N, Wilbring G, Liebing J, Feldman D, Słabicki M, Lippke B, Sib E, Borrajo J, Strecker J, Reinhardt J, Hoffmann P, Cleary B, Hölzel M,  Nöthen MM, Exner M, Ludwig KU, Regev A, Zhang F bioRxiv. 2020 Jun 8. doi: 10.1101/2020.04.06.025635.

Human exome and mouse embryonic expression data implicate ZFHX3, TRPS1, and CHD7 in human esophageal atresia. Zhang R, Gehlen J, Kawalia A, Melissari MT, Dakal TC, Menon AM, Höfele J, Riedhammer K, Waffenschmidt L, Fabian J, Breuer K, Kalanithy J, Hilger AC, Sharma A, Hölscher A, Boemers TM, Pauly M, Leutner A, Fuchs J, Seitz G, Ludwikowski BM, Gomez B, Hubertus J, Heydweiller A, Kurz R, Leonhardt J, Kosch F, Holland-Cunz S, Münsterer O, Ure B, Schmiedeke E, Neser J, Degenhardt P, Märzheuser S, Kleine K, Schäfer M, Spychalski N, Deffaa OJ, Gosemann JH, Lacher M, Heilmann-Heimbach S, Zwink N, Jenetzky E, Ludwig M, Grote P, Schumacher J, Thiele H, Reutter H PLoS One. 2020 Jun 5;15(6):e0234246. doi: 10.1371/journal.pone.0234246.

Dietary plant stanol ester supplementation reduces peripheral symptoms in a mouse model of Niemann-Pick type C1 disease. Magro Dos Reis I, Houben T, Oligschläger Y, Bücken L, Steinbusch H, Cassiman D, Lütjohann D, Westerterp M, Prickaerts J, Plat J, Shiri-Sverdlov R J Lipid Res. 2020 Jun;61(6):830-839. doi: 10.1194/jlr.RA120000632.

Kinetics of oxytocin effects on amygdala and striatal reactivity vary between women and men. Lieberz J, Scheele D, Spengler FB, Matheisen T, Schneider L, Stoffel-Wagner B, Kinfe TM, Hurlemann R Neuropsychopharmacology. 2020 Jun;45(7):1134-1140. doi: 10.1038/s41386-019-0582-6.

Ubiquitin Carboxyl-Terminal Hydrolases (UCHs): Potential Mediators for Cancer and Neurodegeneration. Sharma A, Liu H, Tobar-Tosse F, Chand Dakal T, Ludwig M, Holz FG, Loeffler KU, Wüllner U, Herwig-Carl MC Int J Mol Sci. 2020 May 30;21(11):3910. doi: 10.3390/ijms21113910.

Microbiota-Induced Type I Interferons Instruct a Poised Basal State of Dendritic Cells. Schaupp L, Muth S, Rogell L, Kofoed-Branzk M, Melchior F, Lienenklaus S, Ganal-Vonarburg SC, Klein M, Guendel F, Hain T, Schütze K, Grundmann U, Schmitt V, Dorsch M, Spanier J, Larsen PK, Schwanz T, Jäckel S, Reinhardt C, Bopp T, Danckwardt S, Mahnke K, Heinz GA, Mashreghi MF, Durek P, Kalinke U, Kretz O, Huber TB, Weiss S, Wilhelm C, Macpherson AJ, Schild H, Diefenbach A, Probst HC Cell. 2020 May 28;181(5):1080-1096.e19. doi: 10.1016/j.cell.2020.04.022.

Highly Parallel Profiling of Cas9 Variant Specificity. Schmid-Burgk JL, Gao L, Li D, Gardner Z, Strecker J, Lash B, Zhang F Mol Cell. 2020 May 21;78(4):794-800.e8. doi: 10.1016/j.molcel.2020.02.023.

IGF-I in cord blood is predictive of final height in monozygotic twins with intra-twin birth weight differences. Kasner C, Schulte S, Schreiner F, Fimmers R, Stoffel-Wagner B, Bartmann P, Woelfle J, Gohlke B Clin Endocrinol (Oxf). 2020 May 13. doi: 10.1111/cen.14221.

Obstetric and Neonatal Outcome of Pregnancy in Carney Complex: A Case Report. Ralser DJ, Strizek B, Kupczyk P, Stoffel-Wagner B, Altengarten J, Müller A, Woelfle J, Gembruch U, Klingmueller D, Merz WM, Paschkowiak-Christes A Front Endocrinol. 2020 May 8;11:296. doi: 10.3389/fendo.2020.00296.

Acute Effects of Three Different Meal Patterns on Postprandial Metabolism in Older Individuals with a Risk Phenotype for Cardiometabolic Diseases: A Randomized Controlled Crossover Trial. Schönknecht YB, Crommen S, Stoffel-Wagner B, Coenen M, Fimmers R, Holst JJ, Simon MC, Stehle P, Egert S Mol Nutr Food Res. 2020 May;64(9):e1901035. doi: 10.1002/mnfr.201901035. 

Edible seaweed-derived constituents: an undisclosed source of neuroprotective compounds. Schepers M, Martens N, Tiane A, Vanbrabant K, Liu HB, Lütjohann D, Mulder M, Vanmierlo T Neural Regen Res. 2020 May;15(5):790-795. doi: 10.4103/1673-5374.268894.

Importance of γ-secretase in the regulation of liver X receptor and cellular lipid metabolism. Gutierrez E, Lütjohann D, Kerksiek A, Fabiano M, Oikawa N, Kuerschner L, Thiele C, Walter J Life Sci Alliance. 2020 Apr 30;3(6):e201900521. doi: 10.26508/lsa.201900521.

Immune Sensing of Synthetic, Bacterial, and Protozoan RNA by Toll-like Receptor 8 Requires Coordinated Processing by RNase T2 and RNase 2. Ostendorf T, Zillinger T, Andryka  K, Schlee-Guimaraes TM, Schmitz S, Marx S, Bayrak K, Linke R, Salgert S, Wegner J, Grasser T, Bauersachs S, Soltesz L, Hübner MP, Nastaly M, Coch C, Kettwig M, Roehl I, Henneke M, Hoerauf A, Barchet W, Gärtner J, Schlee M, Hartmann G, Bartok E Immunity. 2020 Apr 14;52(4):591-605.e6. doi: 10.1016/j.immuni.2020.03.009.

Lipid-Droplet Formation Drives Pathogenic Group 2 Innate Lymphoid Cells in Airway Inflammation. Karagiannis F, Masouleh SK, Wunderling K, Surendar J, Schmitt V, Kazakov A, Michla M, Hölzel M, Thiele C, Wilhelm C Immunity. 2020 Apr 14;52(4):620-634.e6. doi: 10.1016/j.immuni.2020.03.003.

High RIG-I expression in ovarian cancer associates with an immune-escape signature and poor clinical outcome. Wolf D, Fiegl H, Zeimet AG, Wieser V, Marth C, Sprung S, Sopper S, Hartmann G, Reimer D, Boesch M Int J Cancer. 2020 Apr 1;146(7):2007-2018. doi: 10.1002/ijc.32818.

HDL inhibits endoplasmic reticulum stress-induced apoptosis of pancreatic β-cells in vitro by activation of Smoothened. Yalcinkaya M, Kerksiek A, Gebert K, Annema W, Sibler R, Radosavljevic S, Lütjohann D, Rohrer L, von Eckardstein A J Lipid Res. 2020 Apr;61(4):492-504. doi: 10.1194/jlr.RA119000509.

High-Sensitivity Troponin T Testing: Consequences on Daily Clinical Practice and Effects on Diagnosis of Myocardial Infarction. Zachoval CF, Dolscheid-Pommerich R, Graeff I, Goldschmidt B, Grigull A, Stoffel-Wagner B, Nickenig G, Zimmer S J Clin Med. 2020 Mar 12;9(3):775. doi: 10.3390/jcm9030775.

Interpreting the Benefit of Simvastatin-Ezetimibe in Patients 75 Years or Older. Weingärtner O, Sijbrands EJG, Lütjohann D JAMA Cardiol. 2020 Feb 1;5(2):234. doi: 10.1001/jamacardio.2019.5197.

Evidence for shrunken pore syndrome in children. den Bakker E, Gemke RJ, van Wijk JA, Hubeek I, Stoffel-Wagner B, Bökenkamp A Scand J Clin Lab Invest. 2020 Feb;80(1):32-38. doi: 10.1080/00365513.2019.1692231.

Levels of 7alpha-hydroxycholesterol and/or 7alpha-hydroxy-4-cholest-3-one are the optimal biochemical markers for the evaluation of treatment of cerebrotendinous xanthomatosis. Lütjohann D, Stellaard F, Björkhem I J Neurol. 2020 Feb;267(2):572-573. doi: 10.1007/s00415-019-09650-0.

Phenprocoumon Dose Requirements, Dose Stability and Time in Therapeutic Range in Elderly Patients With CYP2C9 and VKORC1 Polymorphisms. Schneider KL, Kunst M, Leuchs AK, Böhme M, Weckbecker K, Kastenmüller K, Bleckwenn M, Holdenrieder S, Coch C, Hartmann G, Stingl JC Front Pharmacol. 2020 Jan 28;10:1620. doi: 10.3389/fphar.2019.01620.

Optimizing Clinical Cardiovascular Outcomes by a Personalized Approach to Add Ezetimibe to a Statin. Weingärtner O, Sijbrands EJG, Lütjohann D J Am Coll Cardiol. 2020 Jan 7;75(1):128. doi: 10.1016/j.jacc.2019.08.1072.

Interaction of chylomicron remnants and VLDLs during ultracentrifuge separation based on the Svedberg flotation rate. Stellaard F, Lütjohann D J Intern Med. 2020 Jan;287(1):117. doi: 10.1111/joim.13000.

Rare dyslipidaemias, from phenotype to genotype to management: a European Atherosclerosis Society task force consensus statement. Hegele RA, Borén J, Ginsberg HN, Arca M, Averna M, Binder CJ, Calabresi L, Chapman MJ, Cuchel M, von Eckardstein A, Frikke-Schmidt R, Gaudet D, Hovingh GK, Kronenberg F, Lütjohann D, Parhofer KG, Raal FJ, Ray KK, Remaley AT, Stock JK, Stroes ES, Tokgözoğlu L, Catapano AL Lancet Diabetes Endocrinol. 2020 Jan;8(1):50-67. doi: 10.1016/S2213-8587(19)30264-5.

 

2019:

Three-dimensional spatially resolved geometrical and functional models of human liver tissue reveal new aspects of NAFLD progression. Segovia-Miranda F, Morales-Navarrete H, Kücken M, Moser V, Seifert S, Repnik U, Rost F, Brosch M, Hendricks A, Hinz S, Röcken C, Lütjohann D, Kalaidzidis Y, Schafmayer C, Brusch L, Hampe J, Zerial M Nat Med. 2019 Dec;25(12):1885-1893. doi: 10.1038/s41591-019-0660-7.

Interferon-beta-induced changes in neuroimaging phenotypes of appetitive motivation and reactivity to emotional salience. Coch C, Viviani R, Breitfeld J, Münzer K, Dassler-Plencker J, Holdenrieder S, Coenen M, Steffens M, Müller M, Hartmann G, Stingl J Neuroimage Clin. 2019;24:102020. doi: 10.1016/j.nicl.2019.102020.

The PNPLA3 I148M variant promotes lipid-induced hepatocyte secretion of CXC chemokines establishing a tumorigenic milieu. Nischalke HD, Lutz P, Bartok E, Krämer B, Langhans B, Frizler R, Berg T, Hampe J, Buch S, Datz C, Stickel F, Hartmann G, Strassburg CP, Nattermann J, Spengler U J Mol Med. 2019 Nov;97(11):1589-1600. doi: 10.1007/s00109-019-01836-3.

Adiponectin Limits IFN-gamma and IL-17 Producing CD4 T Cells in Obesity by Restraining Cell Intrinsic Glycolysis. Surendar J, Frohberger SJ, Karunakaran I, Schmitt V, Stamminger W, Neumann AL, Wilhelm C, Hoerauf A, Hübner MP Front Immunol. 2019 Oct 29;10:2555. doi: 10.3389/fimmu.2019.02555.

Estimating fetal cholesterol synthesis rates by cord blood analysis in intrauterine growth restriction and normally grown fetuses. Pecks U, Bornemann V, Klein A, Segger L, Maass N, Alkatout I, Eckmann-Scholz C, Elessawy M, Lütjohann D Lipids Health Dis. 2019 Oct 25;18(1):185. doi: 10.1186/s12944-019-1117-1.

Mutational Landscape of the BAP1 Locus Reveals an Intrinsic Control to Regulate the miRNA Network and the Binding of Protein Complexes in Uveal Melanoma. Sharma A, Biswas A, Liu H, Sen S, Paruchuri A, Katsonis P, Lichtarge O, Chand Dakal T, Maulik U, Gromiha MM, Bandyopadhyay S, Ludwig M, Holz FG, Loeffler KU, Herwig-Carl MC Cancers (Basel). 2019 Oct 19;11(10):1600. doi: 10.3390/cancers11101600.

Optical Pooled Screens in Human Cells. Feldman D, Singh A, Schmid-Burgk JL, Carlson RJ, Mezger A, Garrity AJ, Zhang F, Blainey PC Cell. 2019 Oct 17;179(3):787-799.e17. doi: 10.1016/j.cell.2019.09.016.

Serum Concentration of Plant Sterol Oxidation Products (POP) Compared to Cholesterol Oxidation Products (COP) after Intake of Oxidized Plant Sterols: A Randomised, Placebo-Controlled, Double-Blind Dose‒Response Pilot Study. Lin Y, Koppenol WP, Knol D, Vermeer MA, Hiemstra H, Friedrichs S, Lütjohann D, Trautwein EA Nutrients. 2019 Sep 30;11(10):2319. doi: 10.3390/nu11102319.

Acute Impact of Dietary Pattern and Walking on Postprandial Attention, Mood, and Satiety in Older Adults: A Randomized Crossover Trial. Diekmann C, Wagner M, Huber H, Preuß M, Preuß P, Predel HG, Stoffel-Wagner B, Fimmers R, Stehle P, Egert S Nutrients. 2019 Sep 26;11(10). pii: E2294. doi: 10.3390/nu11102294.

Health-related quality of life and neurocognitive functioning with lomustine-temozolomide versus temozolomide in patients with newly diagnosed, MGMT-methylated glioblastoma (CeTeG/NOA-09): a randomised, multicentre, open-label, phase 3 trial. Weller J, Tzaridis T, Mack F, Steinbach JP, Schlegel U, Hau P, Krex D, Grauer O, Goldbrunner R, Bähr O, Uhl M, Seidel C, Tabatabai G, Brehmer S, Bullinger L, Galldiks N, Schaub C, Kebir S, Stummer W, Simon M, Fimmers R, Coch C, Glas M, Herrlinger U, Schäfer N. Lancet Oncol. 2019 Sep 2. pii: S1470-2045(19)30502-9. doi: 10.1016/S1470-2045(19)30502-9. [Epub ahead of print]

Monozygotic Twins with Birth-Weight Differences: Metabolic Health Influenced more by Genetics or by Environment? Grunewald M, Schulte S, Bartmann P, Stoffel-Wagner B, Fimmers R, Woelfle J, Gohlke B. Horm Res Paediatr. 2019 Aug 14:1-9. doi: 10.1159/000501775. [Epub ahead of print]

Thyroid Function in Monozygotic Twins with Intra-twin Birth Weight Differences: A Prospective Longitudinal Cohort Study. Schulte S, Gohlke B, Schreiner F, Gruenewald M, Fimmers R, Stoffel-Wagner B, Bartmann P, Woelfle J. J Pediatr. 2019 Aug;211:164-171. doi: 10.1016/j.jpeds.2019.03.041.

Need to individualise cholesterol-lowering therapy. Lütjohann D, Weingärtner O, Heart 2019 Aug;105(16):1291-1292. doi: 10.1136/heartjnl-2019-315376.

Moderate Postmeal Walking Has No Beneficial Effects Over Resting on Postprandial Lipemia, Glycemia, Insulinemia, and Selected Oxidative and Inflammatory Parameters in Older Adults with a Cardiovascular Disease Risk Phenotype: A Randomized Crossover Trial. Diekmann C, Huber H, Preuß M, Preuß P, Predel HG, Stoffel-Wagner B, Fimmers R, Stehle P, Egert S, J Nutr. 2019 Jul 18. pii: nxz148. doi: 10.1093/jn/nxz148. [Epub ahead of print]

In vitro effects of sitosterol and sitostanol on mitochondrial respiration in human brown adipocytes, myotubes and hepatocytes. Nascimento EBM, Konings M, Schaart G, Groen AK, Lütjohann D, van Marken Lichtenbelt WD, Schrauwen P, Plat J, Eur J Nutr. 2019 Jul 17. doi: 10.1007/s00394-019-02052-y.

RNA-guided DNA insertion with CRISPR-associated transposases. Strecker J, Ladha A, Gardner Z, Schmid-Burgk JL, Makarova KS, Koonin EV, Zhang F Science. 2019 Jul 5;365(6448):48-53. doi: 10.1126/science.aax9181.

Frequent detection of Saffold cardiovirus in adenoids. Lindner K, Ludwig M, Bootz F, Reber U, Safavieh Z, Eis-Hübinger AM, Herberhold S, PLoS One. 2019 Jul 3;14(7):e0218873. doi: 10.1371/journal.pone.0218873.

Exome chip association study excluded the involvement of rare coding variants with large effect sizes in the etiology of anorectal malformations. van de Putte R, Wijers CHW, Reutter H, Vermeulen SH, Marcelis CLM, Brosens E, Broens PMA, Homberg M, Ludwig M, Jenetzky E, Zwink N, Sloots CEJ, de Klein A, Brooks AS, Hofstra RMW, Holsink SAC, van der Zanden LFM, Galesloot TE, Tam PK, Steehouwer M, Acuna-Hidalgo R, Vorst MV, Kiemeney LA, Garcia-Barceló MM, de Blaauw I, Brunner HG, Roeleveld N, van Rooij IALM. PLoS One. 2019 May 28;14:e0217477. doi: 10.1371/journal.pone.0217477. eCollection 2019.

Rare Variants in BNC2 Are Implicated in Autosomal-Dominant Congenital Lower Urinary-Tract Obstruction. Kolvenbach CM, Dworschak GC, Frese S, Japp AS, Schuster P, Wenzlitschke N, Yilmaz Ö, Lopes FM, Pryalukhin A, Schierbaum L, van der Zanden LFM, Kause F, Schneider R, Taranta-Janusz K, Szczepańska M, Pawlaczyk K, Newman WG, Beaman GM, Stuart HM, Cervellione RM, Feitz WFJ, van Rooij IALM, Schreuder MF, Steffens M, Weber S, Merz WM, Feldkötter M, Hoppe B, Thiele H, Altmüller J, Berg C, Kristiansen G, Ludwig M, Reutter H, Woolf AS, Hildebrandt F, Grote P, Zaniew M, Odermatt B, Hilger AC. Am J Hum Genet. 2019 May 2;104:994-1006. doi: 10.1016/j.ajhg.2019.03.023.

Besnoitia besnoiti infection alters both endogenous cholesterol de novo synthesis and exogenous LDL uptake in host endothelial cells. Silva LMR, Lütjohann D, Hamid P, Velasquez ZD, Kerner K, Larrazabal C, Failing K, Hermosilla C, Taubert A. Sci Rep. 2019 Apr 30;9:6650. doi: 10.1038/s41598-019-43153-2.

Low serum lathosterol levels associate with fatal cardiovascular disease and excess all-cause mortality: a prospective cohort study. Weingärtner O, Lütjohann D, Meyer S, Fuhrmann A, Cremers B, Seiler-Mußler S, Schött HF, Kerksiek A, Friedrichs S, Ulbricht U, Zawada A, Laufs U, Schulze PC, Scheller B, Fliser D, Böhm M, Sijbrands E, Heine GH. Clin Res Cardiol. 2019 Apr 4. doi: 10.1007/s00392-019-01474-2.

Direct RIG-I activation in human NK cells induces TRAIL-dependent cytotoxicity toward autologous melanoma cells. Daßler-Plenker J, Paschen A, Putschli B, Rattay S, Schmitz S, Goldeck M, Bartok E, Hartmann G, Coch C. Int J Cancer 2019 Apr 1;144(7):1645-1656. doi: 10.1002/ijc.31874. Epub 2019 Jan 9.

First international descriptive and interventional survey for cholesterol and non-cholesterol sterol determination by gas- and liquid-chromatography-Urgent need for harmonisation of analytical methods. Lütjohann D, Björkhem I, Friedrichs S, Kerksiek A, Lövgren-Sandblom A, Geilenkeuser WJ, Ahrends R, Andrade I, Ansorena D, Astiasarán I, Baila-Rueda L, Barriuso B, Becker S, Bretillon L, Browne RW, Caccia C, Ceglarek U, Cenarro A, Crick PJ, Fauler G, Garcia-Llatas G, Gray R, Griffiths WJ, Gylling H, Harding S, Helmschrodt C, Iuliano L, Janssen HG, Jones P, Kaipiainen L, Kannenberg F, Lagarda MJ, Leoni V, Lottenberg AM, MacKay DS, Matysik S, McDonald J, Menendez-Carreño M, Myrie SB, Sutti Nunes V, Ostlund RE, Polisecki E, Ramos F, Rideout TC, Schaefer EJ, Schmitz G, Wang Y, Zerbinati C, Diczfalusy U, Schött HF. J Steroid Biochem Mol Biol. 2019 Mar 30;190:115-125. doi: 10.1016/j.jsbmb.2019.03.025.

Human TLR8 Senses RNA From Plasmodium falciparum-Infected Red Blood Cells Which Is Uniquely Required for the IFN-γ Response in NK Cells. Coch C, Hommertgen B, Zillinger T, Daßler-Plenker J, Putschli B, Nastaly M, Kümmerer BM, Scheunemann JF, Schumak B, Specht S, Schlee M, Barchet W, Hoerauf A, Bartok E, Hartmann G. Front Immunol. 2019 Mar 27;10:371. doi: 10.3389/fimmu.2019.00371. eCollection 2019.

Dietary Sargassum fusiforme improves memory and reduces amyloid plaque load in an Alzheimer's disease mouse model. Bogie J, Hoeks C, Schepers M, Tiane A, Cuypers A, Leijten F, Chintapakorn Y, Suttiyut T, Pornpakakul S, Struik D, Kerksiek A, Liu HB, Hellings N, Martinez-Martinez P, Jonker JW, Dewachter I, Sijbrands E, Walter J, Hendriks J, Groen A, Staels B, Lütjohann D, Vanmierlo T, Mulder M. Sci Rep. 2019 Mar 20;9(1):4908. doi: 10.1038/s41598-019-41399-4.

HSPA6: A new autosomal recessive candidate gene for the VATER/VACTERL malformation spectrum. Kause F, Zhang R, Ludwig M, Schmiedeke E, Rissmann A, Thiele H, Altmueller J, Herms S, Hilger AC, Hildebrandt F, Reutter H. Birth Defects Res. 2019 Mar 18. doi: 10.1002/bdr2.1493.

The isoflavones genistein and daidzein increase hepatic concentration of thyroid hormones and affect cholesterol metabolism in middle-aged male rats. Šošić-Jurjević B, Lütjohann D, Renko K, Filipović B, Radulović N, Ajdžanović V, Trifunović S, Nestorović N, Živanović J, Manojlović Stojanoski M, Kӧhrle J, Milošević V. J Steroid Biochem Mol Biol. 2019 Mar 15;190:1-10. doi: 10.1016/j.jsbmb.2019.03.009.

The emerging concept of "individualized cholesterol-lowering therapy": A change in paradigm. Lütjohann D, Stellaard F, Mulder MT, Sijbrands EJG, Weingärtner O. Pharmacol Ther. 2019 Mar 12. pii: S0163-7258(19)30043-9. doi: 10.1016/j.pharmthera.2019.03.004.

Targeted Nanoparticle Delivery of Bifunctional RIG-I Agonists to Pancreatic Cancer. Zillinger T, Hartmann G. Mol Ther. 2019 Mar 6;27(3):491-492. doi: 10.1016/j.ymthe.2019.02.005. Epub 2019 Feb 20. 

Haematopoietic alterations in neonates with congenital diaphragmatic hernia receiving extracorporeal membrane oxygenation support. Dolscheid-Pommerich RC, Kreuzer A, Graeff I, Stoffel-Wagner B, Mueller A, Kipfmueller F. Ann Clin Biochem. 2019 Mar;56(2):247-252. doi: 10.1177/0004563218820052. Epub 2019 Feb 24.

Effect of transcutaneous vagus nerve stimulation on muscle activity in the gastrointestinal tract (transVaGa): a prospective clinical trial. Hong GS, Pintea B, Lingohr P, Coch C, Randau T, Schaefer N, Wehner S, Kalff JC, Pantelis D. Int J Colorectal Dis. 2019 Mar;34(3):417-422. doi: 10.1007/s00384-018-3204-6. Epub 2018 Dec 5.

Plant-based sterols and stanols in health & disease: "Consequences of human development in a plant-based environment?" Plat J, Baumgartner S, Vanmierlo T, Lütjohann D, Calkins KL, Burrin DG, Guthrie G, Thijs C, Te Velde AA, Vreugdenhil ACE, Sverdlov R, Garssen J, Wouters K, Trautwein EA, Wolfs TG, van Gorp C, Mulder MT, Riksen NP, Groen AK, Mensink RP. Prog Lipid Res. 2019 Feb 26;74:87-102. doi: 10.1016/j.plipres.2019.02.003.

Saliva molecular inflammatory profiling in female migraine patients responsive to adjunctive cervical non-invasive vagus nerve stimulation: the MOXY Study. Boström A, Scheele D, Stoffel-Wagner B, Hönig F, Chaudhry SR, Muhammad S, Hurlemann R, Krauss JK, Lendvai IS, Chakravarthy KV, Kinfe TM. J Transl Med. 2019 Feb 22;17(1):53. doi: 10.1186/s12967-019-1801-y.

Lomustine-temozolomide combination therapy versus standard temozolomide therapy in patients with newly diagnosed glioblastoma with methylated MGMT promoter (CeTeG/NOA-09): a randomised, open-label, phase 3 trial. Herrlinger U, Tzaridis T, Mack F, Steinbach JP, Schlegel U, Sabel M, Hau P, Kortmann RD, Krex D, Grauer O, Goldbrunner R, Schnell O, Bähr O, Uhl M, Seidel C, Tabatabai G, Kowalski T, Ringel F, Schmidt-Graf F, Suchorska B, Brehmer S, Weyerbrock A, Renovanz M, Bullinger L, Galldiks N, Vajkoczy P, Misch M, Vatter H, Stuplich M, Schäfer N, Kebir S, Weller J, Schaub C, Stummer W, Tonn JC, Simon M, Keil VC, Nelles M, Urbach H, Coenen M, Wick W, Weller M, Fimmers R, Schmid M, Hattingen E, Pietsch T, Coch C, Glas M; Neurooncology Working Group of the German Cancer Society. Lancet 2019 Feb 16;393(10172):678-688. doi: 10.1016/S0140-6736(18)31791-4. Epub 2019 Feb 14.

Impact of a Usual Serving Size of Flavanol-Rich Cocoa Powder Ingested with a Diabetic-Suitable Meal on Postprandial Cardiometabolic Parameters in Type 2 Diabetics-A Randomized, Placebo-Controlled, Double-Blind Crossover Study. Rynarzewski J, Dicks L, Zimmermann BF, Stoffel-Wagner B, Ludwig N, Helfrich HP, Ellinger S. Nutrients 2019 Feb 16;11(2). pii: E417. doi: 10.3390/nu11020417.

Trauma Disclosure Moderates the Effects of Oxytocin on Intrusions and Neural Responses to Fear. Scheele D, Lieberz J, Goertzen-Patin A, Engels C, Schneider L, Stoffel-Wagner B, Becker B, Hurlemann R. Psychother Psychosom. 2019;88(1):61-63. doi: 10.1159/000496056. Epub 2019 Jan 24.

Selective L4 Dorsal Root Ganglion Stimulation Evokes Pain Relief and Changes of Inflammatory Markers: Part I Profiling of Saliva and Serum Molecular Patterns. Gravius N, Chaudhry SR, Muhammad S, Boström A, Gravius S, Randau T, Scheele D, Westhofen P, Kruppenbacher J, Stoffel-Wagner B, Maier C, Weidlich A, Yearwood TL, Chakravarthy KV, Kramer JM, Hurlemann R, Kinfe TM. Neuromodulation 2019 Jan;22(1):44-52. doi: 10.1111/ner.12866. Epub 2018 Oct 25.

Oxytocin enhances the pain-relieving effects of social support in romantic couples. Kreuder AK, Wassermann L, Wollseifer M, Ditzen B, Eckstein M, Stoffel-Wagner B, Hennig J, Hurlemann R, Scheele D. Hum Brain Mapp. 2019 Jan;40(1):242-251. doi: 10.1002/hbm.24368. Epub 2018 Aug 28.

Oxytocin reduces a chemosensory-induced stress bias in social perception. Maier A, Scheele D, Spengler FB, Menba T, Mohr F, Güntürkün O, Stoffel-Wagner B, Kinfe TM, Maier W, Khalsa SS, Hurlemann R. Neuropsychopharmacology 2019 Jan;44(2):281-288. doi: 10.1038/s41386-018-0063-3. Epub 2018 Apr 12.

 

2018:

Towards a Central Role of ISL1in the Bladder Exstrophy-Epispadias Complex (BEEC): Computational Characterization of Genetic Variants and Structural Modelling. Sharma A, Dakal TC, Ludwig M, Fröhlich H, Mathur R, Reutter H. Genes (Basel). 2018 Dec 5;9(12). pii: E609. doi: 10.3390/genes9120609.

Plasma levels of the oxyphytosterol 7α-hydroxycampesterol are associated with cardiovascular events. Fuhrmann A, Weingärtner O, Meyer S, Cremers B, Seiler-Mußler S, Schött HF, Kerksiek A, Friedrichs S, Ulbricht U, Zawada AM, Laufs U, Scheller B, Fliser D, Schulze PC, Böhm M, Heine GH, Lütjohann D. Atherosclerosis 2018 Dec;279:17-22. doi: 10.1016/j.atherosclerosis.2018.10.010. Epub 2018 Oct 17.

BAX/BAK-Induced Apoptosis Results in Caspase-8-Dependent IL-1β Maturation in Macrophages. Chauhan D, Bartok E, Gaidt MM, Bock FJ, Herrmann J, Seeger JM, Broz P, Beckmann R, Kashkar H, Tait SWG, Müller R, Hornung V. Cell Rep. 2018 Nov 27;25(9):2354-2368.e5. doi: 10.1016/j.celrep.2018.10.087.

Hydroxypropyl-Beta-Cyclodextrin Reduces Inflammatory Signaling from Monocytes: Possible Implications for Suppression of HIV Chronic Immune Activation. Matassoli FL, Leão IC, Bezerra BB, Pollard RB, Lütjohann D, Hildreth JEK, Arruda LB. mSphere 2018 Nov 7;3(6). pii: e00497-18. doi: 10.1128/mSphere.00497-18.

ATG16L1 orchestrates interleukin-22 signaling in the intestinal epithelium via cGAS-STING. Aden K, Tran F, Ito G, Sheibani-Tezerji R, Lipinski S, Kuiper JW, Tschurtschenthaler M, Saveljeva S, Bhattacharyya J, Häsler R, Bartsch K, Luzius A, Jentzsch M, Falk-Paulsen M, Stengel ST, Welz L, Schwarzer R, Rabe B, Barchet W, Krautwald S, Hartmann G, Pasparakis M, Blumberg RS, Schreiber S, Kaser A, Rosenstiel P. J Exp Med. 2018 Nov 5;215(11):2868-2886. doi: 10.1084/jem.20171029. Epub 2018 Sep 25.

Bi-allelic Mutations in LSS, Encoding Lanosterol Synthase, Cause Autosomal-Recessive Hypotrichosis Simplex. Romano MT, Tafazzoli A, Mattern M, Sivalingam S, Wolf S, Rupp A, Thiele H, Altmüller J, Nürnberg P, Ellwanger J, Gambon R, Baumer A, Kohlschmidt N, Metze D, Holdenrieder S, Paus R, Lütjohann D, Frank J, Geyer M, Bertolini M, Kokordelis P, Betz RC. Am J Hum Genet. 2018 Nov 1;103(5):777-785. doi: 10.1016/j.ajhg.2018.09.011. Epub 2018 Oct 25.

Call for an ezetimibe effectiveness test. Lütjohann D, Laufs U, Schulze PC, Weingärtner O. Atherosclerosis 2018 Nov;278:334. doi: 10.1016/j.atherosclerosis.2018.08.028. Epub 2018 Aug 26.

Estimation of GFR in children using rescaled beta-trace protein. den Bakker E, Gemke R, Pottel H, van Wijk JAE, Hubeek I, Stoffel-Wagner B, Bökenkamp A. Clin Chim Acta. 2018 Nov;486:259-264. doi: 10.1016/j.cca.2018.08.021. Epub 2018 Aug 16.

Systemic High-Mobility Group Box-1: A Novel Predictive Biomarker for Cerebral Vasospasm in Aneurysmal Subarachnoid Hemorrhage. Chaudhry SR, Güresir A, Stoffel-Wagner B, Fimmers R, Kinfe TM, Dietrich D, Lamprecht A, Vatter H, Güresir E, Muhammad S. Crit Care Med. 2018 Nov;46(11):e1023-e1028. doi: 10.1097/CCM.0000000000003319.

Stand 19.11.20