Rudolf-Becker-Laboratory
(financed by the Rudolf Becker Foundation)
at the Biomedical Center (BMZ) University of Bonn Medical Center

 

Welcome to the Rudolf-Becker-Laboratory!


Bone metastases in hormone depletion independent prostate cancer is the most important cause of death in patients with adenocarcinoma of the prostate. Published and preliminary data from our lab demonstrate that the transmembrane protein neuropilin-2 is involved in the formation of bone metastases as well as therapy resistance. In close collaboration with the Datta lab at the University of Nebraska Medical Center and cooperation partners at Mayo Clinic Foundation, we have already shown that neuropilin-2 induces stress and therapy resistance in prostate cancer by regulating autophagy and mTOR signaling. Indeed, its expression correlates with disease outcome in different types of cancer like prostate, bladder and pancreatic cancer. Neuropilin-2 is a predictive marker for therapy resistance in bladder cancer. Preliminary data from our lab suggest an important role of neuropilin-2 in homing and colonization of the bone as the most important metastatic site of prostate cancer.

Targeting the immune systems is an important avenue in the therapy of cancer in future. Several studies indicate a high expression of neuropilin-2 in tumor-associated immune cell subset. In cooperation with our American colleagues, we showed that macrophage-derived neuropilin-2 is important for disease progression by regulating a process called efferocytosis.
Taking together all these data, targeting neuropilin-2 might be an important strategy to combat cancer. Indeed, we are currently developing ways to utilize neuropilin-2 for detection and therapy of cancer.

Additionally, we are investigating new candidates with the same potential as biomarkers and future targets of therapy by executing next generation sequencing methodology like RNA sequencing of human tissue in cooperation with our partners in nuclear medicine, urology, oncology, and radiation biology. To validate the potential of these candidates, we will use genetically engineered mouse models to model cancer initiation, progression, and therapy.

 In short:

  • In our lab, we investigate the role of neuropilin-2 and its associated signaling pathways.
  • In collaboration with our partners around the world, we were involved in research studies showing that neuropilin-2
    • is essential for therapy resistance in cancer by regulating autophagy.
    • is an important factor for tumor progression by inducing mTORC2 dependent anti-apoptotic pathways.
    • plays an important role in cancer progression by regulating tumor-associated macrophages by inducing efferocytosis.
    • is important for EGFR trafficking and activation.
    • is important for androgen receptor function in prostate cancer.
    • is a predictive biomarker for radio-chemotherapy in bladder cancer.
  • In our research, we use mouse models, next generation sequencing techniques, and state of the art glycoprotein analysis tools.

Sincerely
Prof. Dr. Michael Muders
michael.muders@ukbonn.de

Rudolf-Becker-Foundation

Rudolf Becker

The Rudolf-Becker-Foundation was established in 2003 by testamentary decree of Mister Rudolf Becker to support translational prostate cancer research.

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Interesting Links

Bases on our research we gathered some interesting links that you are welcome to check out.

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News and Events

January | 2020

Recent studies of our lab demonstrate the significant role of NRP2 in cancer

Recent studies from the Muders group show an important role of neuropilin-2 for cancer progression and therapy

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January | 2020

Cooperation with aTyr Pharma Inc., San Diego, USA

Muders lab intensifies collaboration with aTyr, an American biotech company working on NRP2.

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October | 2018

Macrophage derived NRP2 in cancer immunology

Macrophage derived neuropilin-2 plays an important part in cancer immunology.

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January | 2020

Muders lab on Twitter

Muders lab is on Twitter now: @muderslab

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June | 2020

Muders lab organizes the annual meeting of the German speaking mayo clinic alumni group

The annual meeting of the German speaking chapter of the Mayo Alumni takes place at the University Club of the Rheinische Friedrich-Wilhelms-Universität Bonn.<br>

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January | 2020

Meet our latest lab member

Paul Dix from the University of Bonn joined our lab for his MD thesis

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