Mental and physical stressors are important pathogenetic factors for psychiatric diseases, such as depression or anxiety disorders. However, both animals and humans show individual susceptibility to stress (susceptibility vs. resilience). Deciphering the underlying mechanisms of individual stress effects is urgently needed for the development of preventive and curative therapeutic approaches.
We are an interdisciplinary research group characterising stress-related effects on cortical neuroplasticity and related behavioural changes, identifying resilience factors for these effects and investigating the modulation of these effects in translational preclinical models.
Our translational basic research is located at the interface of psychiatry and neurology. We use the expertise of both disciplines to gain insight into the pathophysiology of stress using state-of-the-art methods such as multimodal in-vivo imaging and a broad spectrum of behavioural tests. At the same time, we focus on the identification of multimodal stress and resilience biomarkers, which we hope to ultimately make useful for humans.
Aileen Sitter, doctor
Nikolaj Speth, MSc Pharmaceutical Science, PhD student
Dr. med. Anne-Kathrin Gellner
Clinic and Polyclinic for Psychiatry and Psychotherapy
University Hospital Bonn AöR
Venusberg Campus 1
It is possible to work on projects for medical doctoral theses as part of the working group. Please send enquiries to the above mentioned e-mail address.