Neuromodulation of Emotion (NEMO)

For every third patient who is in psychiatric treatment because of a depressive disorder, the clinical picture does not respond to a guideline-oriented therapy. This large number of difficult-to-treat depressive diseases suggests a still inadequate neurobiological understanding of the network regulation of negative emotion and the therapeutic modulation of these regulatory processes.

In order to understand the architecture of the regulation of negative emotion better, the NEMO project pursues a translational research strategy in which the activity of important target regions such as Amygdala, hippocampus, nucleus accumbens and prefrontal cortex in human and animal studies is modulated within the emotion-regulating network and the local as well as the global effects of this experimental modulation are investigated.

Nemo integrates measurement data generated by three variants of experimental neuromodulation:

  1. pharmacologically using neurochemical probes;
  2. by stimulating the brains by means of invasive and non-invasive procedures;
  3. optogeneticaly by means of a genetically modified animal model.

We hope to have unique insights into the connectivity and neurochemical of the network regulation of negative emotion and the disruption of this regulation in depression in order to develop new and above all more effective anti-depressant therapy strategies.

The NEMO working group is promoted as a junior research group by the ministry of innovation, science, research and technology (miwft (ministry) of the state of North Rhine-westphalia and by the University of Bonn. In addition, project-related subsidies are made by the German Research Foundation (dfg).

Head of the working group:
Prof. Dr. Dr. Med. Rene Hurlemann
Deputy Director of the clinic and head of the NEMO Working Group
University Hospital Bonn
Sigmund Freud Str. 25
d-53105 bonn, GER
Phone: + 49 (0) 228 287-15057
Fax: + 49 (0) 228 287-16627
E-mail: renehurlemann@me.com

english website of working group NEMO