This research project ist concerned with the validation of the clinical decision support system PGXperts. With the help of this medical product, pharmacogenetic characteristics of individual patients and interaction risk profile of psychiatric drugs are automatically provided to a treating physician. In molecular genetic studies by the Institute of Human Genetics at the University Hospital Bonn these data are automatically analyzed and used to draw conclusions about patients drug metabolism. This will enable physicians to prescribe medication that is personalized and optimized in terms of dosage, pharmacodynamics and -kinetics. Patients with a diagnosis of depression can participate in this study. The study is a joint project of HMG Systems Engineering GmbH, Fürth, the Clinic of Psychiatry and Psychotherapy, the Institute for Experimental and Clinical Pharmacology and the Institute for Medical Informatics and Statistics UKSH and the Human Genetics Institute and the Clinic of Psychiatry and Psychotherapy at the University Hospital Bonn.