PSY-PGx is a research project aimed at the personalization of psychiatric pharmacotherapy and thereby enabling better treatment outcomes. PSY-PGx is a unique, non-commercial international initiative, carried by researchers and non-profit organizations. In first instance, psychiatric patients will be genotyped in a clinical study and their pharmacotherapy will be individualized based on their genetic characteristics. The data collected from this study will be used in the next step to develop an algorithm for personalized psychiatric pharmacotherapy. Data from European biobanks will also be used in this process. This should lead to a novel approach to genome-based, individualized psychiatric pharmacotherapy. This project is an international collaboration of clinics and research institutes worldwide, the international patient-advocacy network Global Alliance of Mental Illness Advocacy Network (GAMIAN) and the World Psychiatric Association (WPA).