Hinweise zum Coronavirus
Das UKB hat hier für Bürger*innen, Patient*innen und Gesundheitspersonal wichtige Informationen zum Coronavirus/SARS-CoV-2/COVID-19 zusammengestellt. ...weiterlesen




Yamada, S., Shimojima, M., Narita, R., Tsukamoto, Y., Kato, H., Saijo, M., and Fujita, T. (2018). RIG-I-Like Receptor and Toll-Like Receptor Signaling Pathways Cause Aberrant Production of Inflammatory Cytokines/Chemokines in a Severe Fever with Thrombocytopenia Syndrome Virus Infection Mouse Model. Journal of virology 92.


Tsukamoto, Y., Ikeda, S., Uwai, K., Taguchi, R., Chayama, K., Sakaguchi, T., Narita, R., Yao, W.-L., Takeuchi, F., and Otakaki, Y., et al. (2018). Rosmarinic acid is a novel inhibitor for Hepatitis B virus replication targeting viral epsilon RNA-polymerase interaction. PloS one 13, e0197664.



Kasumba, D.M., Hajake, T., Oh, S.-W., Kotenko, S.V., Kato, H., and Fujita, T. (2017). A Plant-Derived Nucleic Acid Reconciles Type I IFN and a Pyroptotic-like Event in Immunity against Respiratory Viruses. Journal of immunology (Baltimore, Md. : 1950) 199, 2460-2474.

Yao, W.-L., Ikeda, S., Tsukamoto, Y., Shindo, K., Otakaki, Y., Qin, M., Iwasawa, Y., Takeuchi, F., Kaname, Y., and Chou, Y.-C., et al. (2017). Establishment of a human hepatocellular cell line capable of maintaining long-term replication of hepatitis B virus. International immunology 29, 109-120.

Kato, H., Oh, S.-W., and Fujita, T. (2017). RIG-I-Like Receptors and Type I Interferonopathies. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 37, 207-213.



Oh, S.-W., Onomoto, K., Wakimoto, M., Onoguchi, K., Ishidate, F., Fujiwara, T., Yoneyama, M., Kato, H., and Fujita, T. (2016). Leader-Containing Uncapped Viral Transcript Activates RIG-I in Antiviral Stress Granules. PLoS pathogens 12, e1005444.



Kato, H., and Fujita, T. (2015). RIG-I-like receptors and autoimmune diseases. Curr Opin Immunol 37, 40-45.



Funabiki, M.°, Kato, H.°, Miyachi, Y., Toki, H., Motegi, H., Inoue, M., Minowa, O., Yoshida, A., Deguchi, K., Sato, H., Ito, S., Shiroishi, T., Takeyasu, K., Noda, T., and Fujita, T. (2014). Autoimmune disorders associated with gain of function of the intracellular sensor MDA5. Immunity 40, 199-212. °equal contribution

Yoo, J.-S., Takahasi, K., Ng, C.S., Ouda, R., Onomoto, K., Yoneyama, M., Lai, J.C., Lattmann, S., Nagamine, Y., and Matsui, T., et al. (2014b). DHX36 enhances RIG-I signaling by facilitating PKR-mediated antiviral stress granule formation. PLoS pathogens 10, e1004012.

Tsugawa, Y., Kato, H., Fujita, T., Shimotohno, K., and Hijikata, M. (2014). Critical role of interferon-alpha constitutively produced in human hepatocytes in response to RNA virus infection. PloS one 9, e89869.

Funabiki, M., Kato, H., Miyachi, Y., Toki, H., Motegi, H., Inoue, M., Minowa, O., Yoshida, A., Deguchi, K., and Sato, H., et al. (2014). Autoimmune disorders associated with gain of function of the intracellular sensor MDA5. Immunity 40, 199-212.

Narita, R., Takahasi, K., Murakami, E., Hirano, E., Yamamoto, S.P., Yoneyama, M., Kato, H., and Fujita, T. (2014). A novel function of human Pumilio proteins in cytoplasmic sensing of viral infection. PLoS pathogens 10, e1004417.

Oda, H., Nakagawa, K., Abe, J., Awaya, T., Funabiki, M., Hijikata, A., Nishikomori, R., Funatsuka, M., Ohshima, Y., Sugawara, Y., Yasumi, T., Kato, H., Shirai, T., Ohara, O., Fujita, T., and Heike, T. (2014). Aicardi-Goutieres syndrome is caused by IFIH1 mutations. Am J Hum Genet 95, 121-125.

Kato, H., and Fujita, T. (2014). Autoimmunity caused by constitutive activation of cytoplasmic viral RNA sensors. Cytokine & growth factor reviews 25, 739-743.

Onomoto, K., Yoneyama, M., Fung, G., Kato, H., and Fujita, T. (2014). Antiviral innate immunity and stress granule responses. Trends in immunology 35, 420-428.

Yoo, J.-S., Kato, H., and Fujita, T. (2014). Sensing viral invasion by RIG-I like receptors. Current opinion in microbiology 20, 131-138.



Ng, C.S., Jogi, M., Yoo, J.-S., Onomoto, K., Koike, S., Iwasaki, T., Yoneyama, M., Kato, H., and Fujita, T. (2013). Encephalomyocarditis virus disrupts stress granules, the critical platform for triggering antiviral innate immune responses. Journal of virology 87, 9511-9522.

Hayashi, Y., Onomoto, K., Narita, R., Yoneyama, M., Kato, H., Nakagawa, T., Ito, J., Taura, A., and Fujita, T. (2013). Virus-induced expression of retinoic acid inducible gene-I and melanoma differentiation-associated gene 5 in the cochlear sensory epithelium. Microbes and infection 15, 592-598.

Ori, D., Kato, H., Sanjo, H., Tartey, S., Mino, T., Akira, S., and Takeuchi, O. (2013). Essential roles of K63-linked polyubiquitin-binding proteins TAB2 and TAB3 in B cell activation via MAPKs. Journal of immunology (Baltimore, Md.: 1950) 190, 4037-4045.

Takamatsu, S., Onoguchi, K., Onomoto, K., Narita, R., Takahasi, K., Ishidate, F., Fujiwara, T.K., Yoneyama, M., Kato, H., and Fujita, T. (2013). Functional characterization of domains of IPS-1 using an inducible oligomerization system. PloS one 8, e53578.



Ng, C.S., Kato, H., and Fujita, T. (2012). Recognition of viruses in the cytoplasm by RLRs and other helicases-how conformational changes, mitochondrial dynamics and ubiquitination control innate immune responses. International immunology 24, 739-749.



Kageyama, M., Takahasi, K., Narita, R., Hirai, R., Yoneyama, M., Kato, H., and Fujita, T. (2011). 55 Amino acid linker between helicase and carboxyl terminal domains of RIG-I functions as a critical repression domain and determines inter-domain conformation. Biochemical and biophysical research communications 415, 75-81.

Ouda, R., Onomoto, K., Takahasi, K., Edwards, M.R., Kato, H., Yoneyama, M., and Fujita, T. (2011). Retinoic acid-inducible gene I-inducible miR-23b inhibits infections by minor group rhinoviruses through down-regulation of the very low density lipoprotein receptor. The Journal of biological chemistry 286, 26210-26219.

Kato, H., Takahasi, K., and Fujita, T. (2011). RIG-I-like receptors: cytoplasmic sensors for non-self RNA. Immunological reviews 243, 91-98.



Satoh, T.°, Kato, H.°, Kumagai, Y., Yoneyama, M., Sato, S., Matsushita, K., Tsujimura, T., Fujita, T., Akira, S., and Takeuchi, O. (2010). LGP2 is a positive regulator of RIG-I- and MDA5-mediated antiviral responses. Proc Natl Acad Sci U S A 107, 1512-1517. °equal contribution


Miyake, T., Satoh, T., Kato, H., Matsushita, K., Kumagai, Y., Vandenbon, A., Tani, T., Muta, T., Akira, S., and Takeuchi, O. (2010). IkappaBzeta is essential for natural killer cell activation in response to IL-12 and IL-18. Proceedings of the National Academy of Sciences of the United States of America 107, 17680-17685.

Schulz, O., Pichlmair, A., Rehwinkel, J., Rogers, N.C., Scheuner, D., Kato, H., Takeuchi, O., Akira, S., Kaufman, R.J., and Reis e Sousa, C. (2010). Protein kinase R contributes to immunity against specific viruses by regulating interferon mRNA integrity. Cell host & microbe 7, 354-361.

Poeck, H., Bscheider, M., Gross, O., Finger, K., Roth, S., Rebsamen, M., Hannesschlager, N., Schlee, M., Rothenfusser, S., and Barchet, W., et al. (2010). Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1 beta production. Nature immunology 11, 63-69.



Miyake, T., Kumagai, Y., Kato, H., Guo, Z., Matsushita, K., Satoh, T., Kawagoe, T., Kumar, H., Jang, M.H., and Kawai, T., et al. (2009). Poly I:C-induced activation of NK cells by CD8 alpha+ dendritic cells via the IPS-1 and TRIF-dependent pathways. Journal of immunology (Baltimore, Md. : 1950) 183, 2522-2528.

Matsushita, K., Takeuchi, O., Standley, D.M., Kumagai, Y., Kawagoe, T., Miyake, T., Satoh, T., Kato, H., Tsujimura, T., and Nakamura, H., et al. (2009). Zc3h12a is an RNase essential for controlling immune responses by regulating mRNA decay. Nature 458, 1185-1190.

Papon, L., Oteiza, A., Imaizumi, T., Kato, H., Brocchi, E., Lawson, T.G., Akira, S., and Mechti, N. (2009). The viral RNA recognition sensor RIG-I is degraded during encephalomyocarditis virus (EMCV) infection. Virology 393, 311-318.

Pichlmair, A., Schulz, O., Tan, C.-P., Rehwinkel, J., Kato, H., Takeuchi, O., Akira, S., Way, M., Schiavo, G., and Reis e Sousa, C. (2009). Activation of MDA5 requires higher-order RNA structures generated during virus infection. Journal of virology 83, 10761-10769.

Schlee, M., Roth, A., Hornung, V., Hagmann, C.A., Wimmenauer, V., Barchet, W., Coch, C., Janke, M., Mihailovic, A., and Wardle, G., et al. (2009). Recognition of 5' triphosphate by RIG-I helicase requires short blunt double-stranded RNA as contained in panhandle of negative-strand virus. Immunity 31, 25-34.



Kato, H., Takeuchi, O., Mikamo-Satoh, E., Hirai, R., Kawai, T., Matsushita, K., Hiiragi, A.,Dermody, T.S., Fujita, T., and Akira, S. (2008). Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid-inducible gene-I and melanoma differentiation-associated gene 5. J Exp Med 205, 1601-1610.

Jung, A., Kato, H., Kumagai, Y., Kumar, H., Kawai, T., Takeuchi, O., and Akira, S. (2008). Lymphocytoid choriomeningitis virus activates plasmacytoid dendritic cells and induces a cytotoxic T-cell response via MyD88. Journal of virology 82, 196-206.

Kawagoe, T., Sato, S., Matsushita, K., Kato, H., Matsui, K., Kumagai, Y., Saitoh, T., Kawai, T., Takeuchi, O., and Akira, S. (2008). Sequential control of Toll-like receptor-dependent responses by IRAK1 and IRAK2. Nature immunology 9, 684-691.

Poeck, H., Besch, R., Maihoefer, C., Renn, M., Tormo, D., Morskaya, S.S., Kirschnek, S., Gaffal, E., Landsberg, J., and Hellmuth, J., et al. (2008). 5'-Triphosphate-siRNA: turning gene silencing and Rig-I activation against melanoma. Nature medicine 14, 1256-1263.



Roberts, Z.J., Goutagny, N., Perera, P.-Y., Kato, H., Kumar, H., Kawai, T., Akira, S., Savan, R., van Echo, D., and Fitzgerald, K.A., et al. (2007). The chemotherapeutic agent DMXAA potently and specifically activates the TBK1-IRF-3 signaling axis. The Journal of experimental medicine 204, 1559-1569-

Kumagai, Y., Takeuchi, O., Kato, H., Kumar, H., Matsui, K., Morii, E., Aozasa, K., Kawai, T., and Akira, S. (2007). Alveolar macrophages are the primary interferon-alpha producer in pulmonary infection with RNA viruses. Immunity 27, 240-252.



Kato, H., Takeuchi, O., Sato, S., Yoneyama, M., Yamamoto, M., Matsui, K., Uematsu, S., Jung, A., Kawai, T., Ishii, K.J., Yamaguchi, O., Otsu, K., Tsujimura, T., Koh, C.S., Reis e Sousa, C., Matsuura, Y., Fujita, T., and Akira, S. (2006). Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses. Nature 441, 101-105.

Matsui, K., Kumagai, Y., Kato, H., Sato, S., Kawagoe, T., Uematsu, S., Takeuchi, O., and Akira, S. (2006). Cutting edge: Role of TANK-binding kinase 1 and inducible IkappaB kinase in IFN responses against viruses in innate immune cells. Journal of immunology (Baltimore, Md. : 1950) 177, 5785-5789.

Ishii, K.J., Coban, C., Kato, H., Takahashi, K., Torii, Y., Takeshita, F., Ludwig, H., Sutter, G., Suzuki, K., and Hemmi, H., et al. (2006). A Toll-like receptor-independent antiviral response induced by double-stranded B-form DNA. Nature immunology 7, 40-48.

Hornung, V., Ellegast, J., Kim, S., Brzozka, K., Jung, A., Kato, H., Poeck, H., Akira, S., Conzelmann, K.K., Schlee, M., Endres, S., and Hartmann, G. (2006). 5’-Triphosphate RNA is the ligand for RIG-I. Science 314, 994-997.

Kumar, H., Kawai, T., Kato, H., Sato, S., Takahashi, K., Coban, C., Yamamoto, M., Uematsu, S., Ishii, K.J., Takeuchi, O., and Akira, S. (2006). Essential role of IPS-1 in innate immune responses against RNA viruses. J Exp Med 203, 1795-1803.



Kato, H., Sato, S., Yoneyama, M., Yamamoto, M., Uematsu, S., Matsui, K., Tsujimura, T., Takeda, K., Fujita, T., Takeuchi, O., and Akira, S. (2005). Cell type-specific involvement of RIG-I in antiviral response. Immunity 23, 19-28.

Kawai, T., Takahashi, K., Sato, S., Coban, C., Kumar, H., Kato, H., Ishii, K.J., Takeuchi, O., and Akira, S. (2005). IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction. Nat Immunol 6, 981-988.


Honors and Awards


2015 - 2017

Highly cited researcher


2008 – 2010

Postdoctoral Fellowship for Research Abroad from Japan Society for the Promotion of Science (JSPS)



Yamamura Award, Graduate School of Medicine, Osaka University


2005 – 2008

Research Fellowship for Young Scientists from Japan Society for the Promotion of Science (JSPS)