Publikationen

Bahra M, Kamphues C, Boas-Knoop S, Lippert S, Esendik U, Schüller U, Hartmann W, Waha A, Neuhaus P, Heppner F, Pietsch T, Koch A. Combination of Hedgehog Signaling Blockage and Chemotherapy Leads to Tumor Reduction in Pancreatic Adenocarcinomas. Pancreas. 2011 Nov 9. Epub ahead of print.

Setty P, Gessi M, Waha A, Hammes J, El-Maarri O, Pietsch T, Waha A. Sensitive Determination of BRAF Copy Number in Clinical Samples by Pyrosequencing. Diagn Mol Pathol. 2011 Sep;20(3):148-57.

Beyer M, Thabet Y, Müller RU, Sadlon T, Classen S, Lahl K, Basu S, Zhou X, Bailey-Bucktrout SL, Krebs W, Schönfeld EA, Böttcher J, Golovina T, Mayer CT, Hofmann A, Sommer D, Debey-Pascher S, Endl E, Limmer A, Hippen KL, Blazar BR, Balderas R, Quast T, Waha A, Mayer G, Famulok M, Knolle PA, Wickenhauser C, Kolanus W, Schermer B, Bluestone JA, Barry SC, Sparwasser T, Riley JL, Schultze JL. Repression of the genome organizer SATB1 in regulatory T cells is required for suppressive function and inhibition of effector differentiation. Nat Immunol. 2011 Aug 14;12(9):898-907.

Svendsen A, Verhoeff JJ, Immervoll H, Brøgger JC, Kmiecik J, Poli A, Netland IA, Prestegarden L, Planagumà J, Torsvik A, Kjersem AB, Sakariassen PO, Heggdal JI, Van Furth WR, Bjerkvig R, Lund-Johansen M, Enger PO, Felsberg J, Brons NH, Tronstad KJ, Waha A, Chekenya M. Expression of the progenitor marker NG2/CSPG4 predicts poor survival and resistance to ionising radiation in glioblastoma. Acta Neuropathol. 2011 Aug 24. [Epub ahead of print]

Rolyan H, Feike AC, Upadhaya AR, Waha A, Van Dooren T, Haass C, Birkenmeier G, Pietrzik CU, Van Leuven F, Thal DR. Amyloid-β protein modulates the perivascular clearance of neuronal apolipoprotein E in mouse models of Alzheimer's disease. J Neural Transm. 2011 May;118(5):699-712.

Küchler J, Hartmann W, Waha A, Koch A, Endl E, Wurst P, Kindler D, Mikeska T, Waha A, Goodyer CG, Büttner R, Schilling K, Pietsch T. p75(NTR) induces apoptosis in medulloblastoma cells. Int J Cancer. 2011 Apr 15;128(8):1804-12.

Gessi M, Setty P, Bisceglia M, zur Muehlen A, Lauriola L, Waha A, Giangaspero F, Pietsch T. Supratentorial primitive neuroectodermal tumors of the central nervous system in adults: molecular and histopathologic analysis of 12 cases. Am J Surg Pathol. 2011 Apr;35(4):573-82. Epub ahead of print

Gessi M, Waha A, Setty P, Waha A, Pietsch T. Analysis of KIAA1549-BRAF fusion status in a case of rosette-forming glioneuronal tumor of the fourth ventricle (RGNT). Neuropathology. 2011 Apr 26.

Setty P, Hammes J, Rothämel T, Vladimirova V, Kramm CM, Pietsch T, Waha A. A pyrosequencing-based assay for the rapid detection of IDH1 mutations in clinical samples. J Mol Diagn. 2010 Nov;12(6):750-6.

Waha A, Felsberg J, Hartmann W, von dem Knesebeck A, Mikeska T, Joos S, Wolter M, Koch A, Yan PS, Endl E, Wiestler OD, Reifenberger G, Pietsch T, Waha A. DUSP4/MKP-2 is inactivated by DNA hypermethylation and acts as a growth suppressor in glioma cells. Cancer Res. 2010, 15: 1689-99.

Schüffler P, Mikeska T, Waha A, Lengauer T, Bock C. MethMarker: user-friendly design and optimization of gene-specific DNA methylation assays. Genome Biol. 2009, 10: R105.

Kurzwelly D, Glas M, Roth P, Weimann E, Lohner H, Waha A, Schabet M, Reifenberger G, Weller M, Herrlinger U. Primary CNS lymphoma in the elderly: temozolomide therapy and MGMT status. J Neurooncol. 2009 Oct 20 (Epub ahead of print).

Gaiser T, Waha A, Moessler F, Bruckner T, Pietsch T, von Deimling A. Comparison of automated silver enhanced in situ hybridization and fluorescence in situ hybridization for evaluation of epidermal growth factor receptor status in human glioblastomas. Mod Pathol. 2009, 22: 1263-71.

Vladimirova V, Mikeska T, Waha A, Soerensen N, Xu J, Reynolds PC, Pietsch T. Aberrant methylation and reduced expression of LHX9 in malignant gliomas of childhood. Neoplasia. 2009, 11: 700-11.

El-Maarri O, Kareta MS, Mikeska T, Becker T, Diaz-Lacava A, Junen J, Nüsgen N, Behne F, Wienker T, Waha A, Oldenburg J, Chédin F. A systematic search for DNA methyltransferase polymorphisms reveals a rare DNMT3L variant associated with subtelomeric hypomethylation. Hum Mol Genet. 2009, 18:1755-68.

Nagane M, Nozue K, Shimizu S, Waha A, Miyazaki H, Kurita H, Homori M, Fujioka Y, Shiokawa Y. Prolonged and severe thrombocytopenia with pancytopenia induced by radiation-combined temozolomide therapy in a patient with newly diagnosed glioblastoma--analysis of O6-methylguanine-DNA methyltransferase status. J. Neurooncol. 2009, 92: 227-32.

Requardt RP, Kaczmarczyk L, Dublin P, Wallraff-Beck A, Mikeska T, Degen J, Waha A, Steinhäuser C, Willecke K, Theis M. Quality control of astrocyte-directed Cre transgenic mice: the benefits of a direct link between loss of gene expression and reporter activation. Glia. 2009, 57: 680-92.

Pieper HC, Evert BO, Kaut O, Riederer PF, Waha A, Wüllner U. Different methylation of the TNF-alpha promoter in cortex and substantia nigra: Implications for selective neuronal vulnerability. Neurobiol Dis. 2008, 32: 521-7.

Runx2 is expressed in human glioma cells and mediates the expression of galectin-3. Vladimirova V, Waha A, Lückerath K, Pesheva P, Probstmeier R. J Neurosci Res. 2008, 86: 2450-61.

Thal DR, Rosentreter A, Xavier CP, Waha A, Pietsch T, Stumpf M, Noegel AA, Clemen CS. Expression of coronin 3 in diffuse gliomas is related to malignancy, J Pathol. 2008, 214: 415-24.

Thakur NN, El-Gogo S, Steer B, Freimüller K, Waha A, Adler H. A gammaherpesviral internal repeat contributes to latency amplification. PLoS ONE. 2007, 2(1):e733.

Mikeska T, Bock C, El-Maarri O, Hübner A, Ehrentraut D, Schramm J, Felsberg J, Kahl P, Büttner R, Pietsch T and Waha A. Optimization of quantitative MGMT promoter methylation analysis using Pyrosequencing and COBRA. Journal of Molecular Diagnostics. 2007, 9(3):368-81.

Versmold B, Felsberg J, Mikeska T, Ehrentraut D, Kohler J, Hampl JA, Rohn G, Niederacher D, Betz B, Hellmich M, Pietsch T, Schmutzler RK, Waha A. Epigenetic silencing of the candidate tumor suppressor gene PROX1 in sporadic breast cancer. Int J Cancer. 2007,121(3):547-54.

Waha A, Koch A, Hartmann W, Milde U, Felsberg J, Hübner A, Mikeska T, Goodyer CG, Sörensen N, Lindberg I, Wiestler OD, Pietsch T and Waha A. SGNE1/7B2 is epigenetically altered and transcriptionally down-regulated in human medulloblastomas. Oncogene. 2007, 26:5662-8.

Koch A, Hrychyk A, Hartmann W, Waha A, Mikeska T, Waha A, Schüller U, Sörensen N, Berthold F, Goodyer CG, Wiestler OD, Birchmeier W, Behrens J, Pietsch T. Mutations of the Wnt antagonist AXIN2 (Conductin) result in TCF-dependent transcription in medulloblastomas. Int J Cancer. 2007; 121(2):284-91.

Felsberg J, Yan PS, Huang TH, Milde U, Schramm J, Wiestler OD, Reifenberger G, Pietsch T and Waha A. DNA methylation and allelic losses on chromosome arm 14q in oligodendroglial tumours. Neuropathol Appl Neurobiol, 2006, 32(5):517-24.

Koch A, Waha A, Hartmann W, Hrychyk A, Schüller U, Waha A, Wharton Jr KA, Fuchs SY, von Schweinitz D, Pietsch T. Elevated expression of Wnt antagonists is a common event in hepatoblastomas. Clin Cancer Res. 2005, 11(12): 3019-27.

Waha A, Güntner S, Huang TH-M, Yan PS, Arslan B, Pietsch T, Wiestler OD, Waha A. Epigenetic silencing of the protocadherin family member PCDH-γ-A11 in astrocytomas. Neoplasia 2005, 7(3):193-9.

Koch A, Weber N, Waha A, Hartmann W, Denkhaus D, Behrens J, Birchmeier W, von Schweinitz D and Pietsch T. Mutations and elevated transcriptional activity of conductin (AXIN2) in hepatoblastomas. J Pathol, 2004, 204(5):546-54.

Waha A, Rodrigues FJ, Waha A, Meyer-Puttlitz B, Cavenee WK, Huang TH-M, Yan PS. Methylation profiling identities epigenetic markers for high-grade gliomas. Cancer Genomics and Proteomics 2004, 1:209-214.

Waha A, Koch A, Hartmann W, Mack H, Schramm J, Sörensen N, Berthold F, Wiestler OD, Pietsch T, Waha A. Analysis of HIC-1 methylation and transcription in human ependymomas. Int J Cancer. 2004, 110(4):542-9.

Kuklinski S, Vladimirova V, Waha A, Kamata H, Pesheva P and Probstmeier R. Expression of galectin-3 in neuronally differentiating PC12 cells is regulated both via Ras/MAPK-dependent and -independent signalling pathways. J Neurochem, 2003, 87(5):1112-24.

Waha A, Waha A, Koch A, Meyer-Puttlitz B, Weggen S, Sörensen N, Tonn JC, Albrecht S, Goodyer CG, Berthold F, Wiestler OD, Pietsch T. Epigenetic silencing of the HIC-1 gene in human medulloblastomas. J Neuropathol Exp Neurol. 2003, 62(11):1192-201.

Hartmann W, Waha A, Koch A, Albrecht S, Gray SG, Ekstrom TJ, von Schweinitz D, Pietsch T. Promoter-specific transcription of the IGF2 gene: a novel rapid, non-radioactive and highly sensitive protocol for mRNA analysis. Virchows Arch. 2001, 439(6):803-7.

Hartmann W, Waha A, Koch A, Goodyer CG, Albrecht S, von Schweinitz D, Pietsch T. p57(KIP2) is not mutated in hepatoblastoma but shows increased transcriptional activity in a comparative analysis of the three imprinted genes p57(KIP2), IGF2, and H19. Am J Pathol. 2000, 157(4):1393-403.

Blümcke I, Becker AJ, Klein C, Scheiwe C, Lie AA, Beck H, Waha A, Friedl MG, Kuhn R, Emson P, Elger C, Wiestler OD. Temporal lobe epilepsy associated up-regulation of metabotropic glutamate receptors: correlated changes in mGluR1 mRNA and protein expression in experimental animals and human patients. J Neuropathol Exp Neurol. 2000, 59(1):1-10.

von Deimling A, Fimmers R, Schmidt MC, Bender B, Fassbender F, Nagel J, Jahnke R, Kaskel P, Duerr EM, Koopmann J, Maintz D, Steinbeck S, Wick W, Platten M, Müller DJ, Przkora R, Waha A, Blümcke B, Wellenreuther R, Meyer-Puttlitz B, Schmidt O, Mollenhauer J, Poustka A, Stangl AP, Lenartz,D, von Ammon K, Henson JW, Schramm J, Louis DN, Wiestler OD. Comprehensive allelotype and genetic analysis of 466 human nervous system tumors. J. Neuropathol. Exp. Neurol. 2000, 59(6): 544-558.

Nijjar T, Wigington D, Garbe JC, Waha A, Stampfer MR, Yaswen P. p57KIP2 expression and loss of heterozygosity during immortal conversion of cultured human mammary epithelial cells. Cancer Res. 1999, 59(20):5112-8. Schramm M, Falkai P, Tepest R, Schneider-Axmann T, Przkora R, Waha A, Pietsch T, Bonte W, Bayer TA. Stability of RNA transcripts in human post-mortem brain. J Neural Transm. 1999, 106(3-4) 329-35.

Peters N, Waha A, Wellenreuther R, Friedrich RE, Mautner VF, Hoffmeyer S, Lenartz D. Schramm J, Wiestler OD, von Deimling A. Quantitative analysis of NF1 and OMGP gene transcripts in sporadic gliomas, sporadic meningiomas, and neurofibro-matosis typpe 1- associated plexiform neurofibromas. Acta Neuropathol. 1999, 97(6): 547-551.

Müller MB, Schmidt MC, Schmidt O, Hayashi Y, Rollbrocker B, Waha A, Fimmers R, Volk B, Warnke PC, Ostertag CB, Wiestler OD, von Deimling A. Molecular genetic analysis as a tool for evaluating stereotactic biopsies of glioma specimens. J. Neuropathol. Exp. Neurol. 1999, 58(1): 40-45.

Waha A, Sturne C, Kessler A, Koch A, Kreyer E, Fimmers R, Wiestler OD, von Deimling A, Krebs D, Schmutzler RK. Expression of the ATM gene is significantly reduced in sporadic breast carcinomas. Int J Cancer. 1998, 78(3):306-9.

Waha A, Watzka M, Koch A, Pietsch T, Przkora R, Peters N, Wiestler OD, von Deimling A. A rapid and sensitive protocol for competitive reverse transcriptase (cRT) PCR analysis of cellular genes. Brain Pathol. 1998, 8(1):13-8.

Wellenreuther R, Waha A, Vogel Y, Lenartz D, Schramm J. Wiestler OD, von Deimling, A. Quantitative analysis of neurofibromatosis type 2 gene transcripts in meningiomas supports the concept of distinct molecular variants. Lab. Invest. 1997, 77(6): 601-606.

Platten M, Meyer-Puttlitz B, Blümcke I, Waha A. Wolf HK, Nothen MM, Louis DN, Sampson JR, von Deimling A. A novel splice site associated polymorphism in the tuberous sclerosis 2 (TSC2) gene may predispose to the development of sporadic gangliogliomas. J Neuropathol Exp Neurol. 1997, 56(7), 806-10.

Meyer-Puttlitz B, Hayashi Y, Waha A, Rollbrocker B, Boström J, Wiestler OD, Louis DN, Reifenberger G, von Deimling A. Molecular genetic analysis of giant cell glioblastomas. Am. J. Pathol. 1997, 151(3): 853-857.

Watzka M, Waha A, Koch A, Schmutzler RK, Bidlingmaier F, von Deimling A, Klingmuller D, Stoffel-Wagner B. An optimized protocol for mRNA quantification using nested competitive RT-PCR. Biochem Biophys Res Commun. 1997, 231(3):813-7.

Hayashi Y, Ueki K, Waha A, Wiestler OD, Louis DN, von Deimling A. Close association of EGFR gene amplification and CDKN2 (p16/MTS1) gene deletion in glioblastoma multiforme. Brain Pathol. 1997, 7(3): 871-875.

Pietsch T, Waha A, Koch A, Kraus J, Albrecht S, Tonn J, Sorensen N, Berthold F, Henk B, Schmandt N, Wolf HK, von Deimling A, Wainwright B, Chenevix-Trench G, Wiestler OD, Wicking C. Medulloblastomas of the desmoplastic variant carry mutations of the human homologue of Drosophila patched. Cancer Res. 1997, 57(11):2085-8.

Rollbrocker B, Waha A, Louis DN, Wiestler OD, von Deimling A. Amplification of the cyclin-dependent kinase 4 (CDK4) gene is associated with high cdk4 protein levels in glioblastoma multiforme. Acta Neuropathol. 1996, 92(1): 70-74.

Hermanson M, Funa K, Koopmann J, Maintz D, Waha A, Westermark B, Heldin CH, Wiestler OD, Louis DN, von Deimling A, Nister M. Association of loss of heterozygosity on chromosome 17p with high platelet-derived growth factor receptor expression in human malignant gliomas. Cancer Res. 1996, 56(1): 164-171.

Waha A, Rollbrocker B, Wiestler OD, von Deimling A. A polymerase chain reaction-based assay for the rapid detection of gene amplification in human tumors. Diagnost. Mol. Pathol. 1996, 5(2): 147-150.

Waha A, Baumann A, Wolf HK, Fimmers R, Neumann J, Kindermann D, Astrahantseff, K, Blümcke I., von Deimling A., Schlegel U. Lack of prognostic relevance of alterations in the epidermal growth factor receptor-transforming growth factor-alpha pathway in human astrocytic gliomas. J Neurosurg. 1996, 85(4): 634-41.

Albrecht S, Waha A, Koch A, Kraus JA, Goodyer CG, Pietsch T. Variable imprinting of H19 and IGF2 in fetal cerebellum and medulloblastoma. J Neuropathol Exp Neurol. 1996, 55(12):1270-6.

Simon M, von Deimling A, Larson JJ, Wellenreuther R, Kaskel P, Waha A, Warnick RE, Tew JM Jr, Menon AG. Allelic losses on chromosomes 14, 10, and 1 in atypical and malignant meningiomas: a genetic model of meningioma progression. Cancer Res. 1995, 55(20):4696-701.

Schober R, Bilzer T, Waha A, Reifenberger G, Wechsler W, von Deimling A, Wiestler OD, Westphal M, Kemshead JT, Vega F, Delattre J-Y and Stasiecki-Steinfeld, P. The epidermal growth factor receptor in glioblastoma: genomic amplification, protein expression, and patient survival data in a therapeutic trial. Clin Neuropathol. 1995, 14(3):169-74.

Albrecht S, von Schweinitz D, Waha A, Kraus JA, von Deimling A, Pietsch T. Loss of maternal alleles on chromosome arm 11p in hepatoblastoma. Cancer Res. 1994, 54(19):5041-4.

von Deimling A, Bender B, Jahnke R Waha A, Kraus J, Albrecht S, Wellenreuther R, Fassbender F, Nagel J, Menon,AG, Louis DN, Lenartz D, Schramm J. and Wiestler OD. Loci associated with malignant progression in astrocytomas: a candidate on chromosome 19q. Cancer Res. 1994, 54(6):1397-401.