Prof. Dr. med. dent. James Deschner
Experimental Dento-Maxillo-Facial Medicine
Center of Dento-Maxillo-Facial Medicine
University of Bonn
First Funding Period
The effect of functional loading on periodontal wound healing in regenerative therapy with enamel matrix derivatives
Periodontitis is a multicausal inflammatory disease associated with loss of periodontal attachment, collagen, and alveolar bone. The regeneration of lost periodontal structures can be supported by the application of enamel matrix derivatives (EMD) as well as growth and differentiation factors. Recent studies on cartilage explants and tissue engineered constructs have reveiled that growth factors act in concert with biomechanical signals that can both enhance and inhibit the anabolic effects of biological mediators.So far, the effect of mechanical loading on periodontal wound healing events in modern regenerative treatment approaches has been very much neglected. Since the periodontium comprises load-bearing tissues, the study of potential interactions between bioactive factors and biomechanical signals is critical to optimize periodontal wound healing. This study therefore proposes to examine interactions of mechanical signals with the effects of EMD by application of mechanical load to EMD-treated periodontal ligament cells in vitro and by generation of different loading conditions in an in vivo experimental periodontal wound model. Furthermore, the mechanisms underlying the potential interactions between biological and mechanical factors will be analyzed at cellular and molecular level.