MicroRNAs: Exploring the Role of MicroRNAs on Photoreceptors In Vitro and In Vivo

The loss of photoreceptors in inherited retinal diseases (IRDs) and age-related macular degeneration (AMD) results in severe visual impairment that drastically affects quality of life. Despite advances in treatment, current therapies often struggle to address the genetic and environmental complexity of these diseases. There is an urgent need for broadly applicable strategies that can protect and support photoreceptors independent of specific genetic mutations. Our research focuses on a promising solution: a subset of specific microRNAs (miRNAs) with the potential to protect photoreceptors from degeneration. Using both mouse models of retinal disease and human retinal organoids, we are investigating how these miRNAs contribute to photoreceptor survival, development, and function. Using cutting-edge molecular and genetic analysis, we aim to uncover the protective mechanisms of miRNAs and harness their therapeutic potential to prevent vision loss. This innovative approach has the potential to revolutionize the treatment of retinal degeneration by providing a mutation-independent strategy to preserve vision. By deepening our understanding of miRNA function in the retina, we are paving the way for novel interventions that could benefit a wide range of patients affected by IRDs and AMD. Our work is a step forward in developing effective, long-lasting treatments for retinal diseases and restoring hope for those at risk of blindness. This work is funded by DFG.