von Wrede / Moskau-Hartmann Workgroup - Clinical Epileptology

Our group addresses issues concerning clinical epileptology as well as the patient-centered care structures of patients with epilepsy and other seizure disorders. Our current key aspects are treatment options with transcutaneous vagus nerve stimulation, invasive vagus nerve stimulation, and cannabidiol.

Staff:

• Mostafa Badr
• Dr. Anja Ivo
• Luise Kilburg
• Dr. Jan Pukropski
• Vicky Rau
• André Reichel
• Celina Schmidt
• Mar Isabel Brugués Villalba

Current publications (selected):

• Wrede R von, Witt J-A, Auvin S, Devlin A, Lagae L, Marson A, Meador KJ, O Brien TJ, Park J, Surges R, Trinka E, Wiebe S, Helmstaedter C (2023) Unjustified allegation on cancer risks in children of mothers with epilepsy taking high-dose folic acid during pregnancy - No proof of a causal relationship. Epilepsia. doi:10.1111/epi.17680.
• Wrede R von, Witt J-A, Helmstaedter C (2023) Big Data - Big Trouble: The two faces of publishing results from big data studies based on cohorts with poor clinical definition. Seizure 111:21–22.
• Schach S, Rings T, Bregulla M, Witt J-A, Bröhl T, Surges R, Wrede R von, Lehnertz K, Helmstaedter C (2022) Electrodermal Activity Biofeedback Alters Evolving Functional Brain Networks in People With Epilepsy, but in a Non-specific Manner. Front Neurosci 16:828283.
• Wrede R von, Bröhl T, Rings T, Pukropski J, Helmstaedter C, Lehnertz K (2022) Modifications of Functional Human Brain Networks by Transcutaneous Auricular Vagus Nerve Stimulation: Impact of Time of Day. Brain Sci 12.
• Wrede R von, Rings T, Bröhl T, Pukropski J, Schach S, Helmstaedter C, Lehnertz K (2022) Transcutaneous Auricular Vagus Nerve Stimulation Differently Modifies Functional Brain Networks of Subjects With Different Epilepsy Types. Front Hum Neurosci 16:867563.
• Rings T, Wrede R von, Bröhl T, Schach S, Helmstaedter C, Lehnertz K (2021) Impact of Transcutaneous Auricular Vagus Nerve Stimulation on Large-Scale Functional Brain Networks: From Local to Global. Front Physiol 12:700261.
• Wrede R von, Helmstaedter C, Surges R (2021) Cannabidiol in the Treatment of Epilepsy. Clin Drug Investig. doi:10.1007/s40261-021-01003-y.
• Wrede R von, Pukropski J, Moskau-Hartmann S, Surges R, Baumgartner T (2021) COVID-19 vaccination in patients with epilepsy: First experiences in a German tertiary epilepsy center. Epilepsy Behav 122:108160.
• Wrede R von, Rings T, Schach S, Helmstaedter C, Lehnertz K (2021) Transcutaneous auricular vagus nerve stimulation induces stabilizing modifications in large-scale functional brain networks: towards understanding the effects of taVNS in subjects with epilepsy. Sci Rep 11:7906.
• Wrede R von, Surges R (2021) Patient-zu-Arzt-Anwendungen in der ambulanten Epilepsieversorgung. Z. Epileptol. 34:306–310.
• Wrede R von, Surges R (2021) Transcutaneous vagus nerve stimulation in the treatment of drug-resistant epilepsy. Auton Neurosci 235:102840.
• Wrede R von, Moskau-Hartmann S, Amarell N, Surges R, Erich Elger C, Helmstaedter C (2020) Plant derived versus synthetic cannabidiol: Wishes and commitment of epilepsy patients. Seizure 80:92–95.
• Wrede R von, Moskau-Hartmann S, Baumgartner T, Helmstaedter C, Surges R (2020) Counseling of people with epilepsy via telemedicine: Experiences at a German tertiary epilepsy center during the COVID-19 pandemic. Epilepsy Behav 112:107298.
• Wrede R von, Moskau-Hartmann S, Amarell N, Elger CE, Helmstaedter C (2019) Knowledge, expectations and fears of cannabis use of epilepsy patients at a tertiary epilepsy center. Epilepsy Behav 99:106458.
• Wrede R von, Moskau-Hartmann S, Rüber T, Helmstaedter C, Surges R (2019) Sustained seizure freedom with transcutaneous vagal nerve stimulation in drug-resistant epilepsy caused by subcortical band heterotopias. Seizure 70:25–26.
• Müller I, Elger CE, Wrede R von (2009) Social aspects in epilepsy: educational, employment and social situation in patients with epilepsy. Abstracts of the 6th Joint Meeting of the German, Austrian, and Swiss Sections of the International League Against Epilepsy. Epilepsia 50:43.