RG Neurohomeostasis

Welcome to the Neurohomeostasis Lab! Our research focuses on the regulation of autophagy and its interaction with stress. A particular emphasis is placed on the role of FKBP51, a versatile protein that plays a key part in the stress response and is linked to metabolism, immune reactions, and autophagy. Our goal is to uncover the complex mechanisms of stress and its effects on cellular function, especially proteostasis. To validate our basic research findings and identify therapeutic targets for the treatment of neuropsychiatric disorders, we conduct both preclinical and clinical studies.

We pursue a multidisciplinary and translational approach that integrates cell models, animal experiments, and human studies with protein biochemistry, ex vivo pharmacology, and multi-omics technologies. To address our research questions, we use targeted biochemical methods (e.g., Western blot, qPCR, ELISA) and cutting-edge omics techniques (phospho-/proteomics, metabolomics, transcriptomics), tailored to each project. This comprehensive methodology expands our understanding of cellular function under stress and explores the signaling pathways essential for cellular equilibrium (homeostasis). In our interdisciplinary, translational projects, we apply standard psychiatric research tools such as rating scales, questionnaires, and neuropsychological assessments. We also use wearable devices to collect physiological data. A central aspect of our human studies is the molecular analysis of participant blood samples. Here, we apply specialized ex vivo stimulation protocols to test metabolic or immunological responses.