Komplementäre Therapieverfahren

Wir beschäftigen uns mit Fragestellungen der klinischen Epileptologie und zu Versorgungsstrukturen von Patient*innen mit Epilepsie und anderen Anfallserkrankungen. Aktueller Schwerpunkt sind u.a. die Behandlungsmöglichkeiten mittels transkutaner Vagusnerv-Stimulation, invasiver Vagusnerv-Stimulation sowie mit Cannabidiol.

Aktuelle Publikationen (Auswahl):

• Badr M, Helmstaedter C, Moskau-Hartmann S, Pukropski J, Witt J-A, Rüber T, Dague KO, Baumgartner T, Rademacher M, Surges R, Wrede R von (2025) Cenobamate in Real-Word Scenario: Results on Efficacy, Side Effects, and Retention Rate in a Single Center Retrospective Study. Brain Behav 15:e70567.
• Held NR et al. (2025) Quantitative susceptibility mapping at 7T as a biomarker of post- and interictal extravascular iron in patients with focal epilepsy. EBioMedicine 122:106040.
• Kilburg RL, Moskau-Hartmann S, Helmstaedter C, Surges R, Wrede R von (2025) Green epileptology: Acceptance of telemedical follow-up under climate protection aspects. Epilepsia Open. doi:10.1002/epi4.70162.
• Witt J-A, Badr M, Surges R, Wrede R von, Helmstaedter C (2025) The Effects of Cenobamate and Its Dosage on Cognition: A Retrospective Longitudinal Study in 84 Individuals with Epilepsy. CNS Drugs. doi:10.1007/s40263-025-01196-2.
• Bauer T et al. (2024) Rasmussen’s encephalitis: structural, functional, and clinical correlates of contralesional epileptiform activity. J Neurol 271:6680–6691.
• Bitzer F et al. (2024) Higher Validity, Lower Radiation: A New Ictal Single-Photon Emission Computed Tomography Framework. Ann Neurol 96:1160-1173.
• Bröhl T, Rings T, Pukropski J, Wrede R von, Lehnertz K (2024) The time-evolving epileptic brain network: concepts, definitions, accomplishments, perspectives. Front Netw Physiol 3:1338864.
• Holtkamp M et al. (2024) Erster epileptischer Anfall und Epilepsien im Erwachsenenalter : Kurzfassung S2k-Leitlinie der Deutschen Gesellschaft für Neurologie in Zusammenarbeit mit der Deutschen Gesellschaft für Epileptologie = First epileptic seizure and epilepsies in adulthood : abridged version of the S2k guideline of the German Society for Neurology in cooperation with the German Society for Epileptology. Clin Epileptol 37:118–139.
• Pukropski J, Baumann J, Jordan A, Bausch M, Wrede R von, Surges R (2024) Short-term effects of transcutaneous auricular vagus nerve stimulation on T-wave alternans in people with focal epilepsy - An exploratory pilot study. Epilepsy Behav Rep 26:100657.
• Walger L et al. (2024) A Quantitative Comparison Between Human and Artificial Intelligence in the Detection of Focal Cortical Dysplasia. Invest Radiol 60:253-259.
• Wrede R von, Witt J-A, Jessen N, Lossius MI, Moskau-Hartmann S, Helmstaedter C (2024) Screening for depression in patients with epilepsy: What are the benefits for physicians and patients in the real-life setting. Epilepsia 65:3076-3082.
• Wrede R von, Witt J-A, Auvin S, Devlin A, Lagae L, Marson A, Meador KJ, O Brien TJ, Park J, Surges R, Trinka E, Wiebe S, Helmstaedter C (2023) Unjustified allegation on cancer risks in children of mothers with epilepsy taking high-dose folic acid during pregnancy - No proof of a causal relationship. Epilepsia. doi:10.1111/epi.17680.
• Wrede R von, Witt J-A, Helmstaedter C (2023) Big Data - Big Trouble: The two faces of publishing results from big data studies based on cohorts with poor clinical definition. Seizure 111:21–22.
• Schach S, Rings T, Bregulla M, Witt J-A, Bröhl T, Surges R, Wrede R von, Lehnertz K, Helmstaedter C (2022) Electrodermal Activity Biofeedback Alters Evolving Functional Brain Networks in People With Epilepsy, but in a Non-specific Manner. Front Neurosci 16:828283.
• Wrede R von, Bröhl T, Rings T, Pukropski J, Helmstaedter C, Lehnertz K (2022) Modifications of Functional Human Brain Networks by Transcutaneous Auricular Vagus Nerve Stimulation: Impact of Time of Day. Brain Sci 12.
• Wrede R von, Rings T, Bröhl T, Pukropski J, Schach S, Helmstaedter C, Lehnertz K (2022) Transcutaneous Auricular Vagus Nerve Stimulation Differently Modifies Functional Brain Networks of Subjects With Different Epilepsy Types. Front Hum Neurosci 16:867563.
• Rings T, Wrede R von, Bröhl T, Schach S, Helmstaedter C, Lehnertz K (2021) Impact of Transcutaneous Auricular Vagus Nerve Stimulation on Large-Scale Functional Brain Networks: From Local to Global. Front Physiol 12:700261.
• Wrede R von, Helmstaedter C, Surges R (2021) Cannabidiol in the Treatment of Epilepsy. Clin Drug Investig. doi:10.1007/s40261-021-01003-y.
• Wrede R von, Pukropski J, Moskau-Hartmann S, Surges R, Baumgartner T (2021) COVID-19 vaccination in patients with epilepsy: First experiences in a German tertiary epilepsy center. Epilepsy Behav 122:108160.
• Wrede R von, Rings T, Schach S, Helmstaedter C, Lehnertz K (2021) Transcutaneous auricular vagus nerve stimulation induces stabilizing modifications in large-scale functional brain networks: towards understanding the effects of taVNS in subjects with epilepsy. Sci Rep 11:7906.
• Wrede R von, Surges R (2021) Patient-zu-Arzt-Anwendungen in der ambulanten Epilepsieversorgung. Z. Epileptol. 34:306–310.
• Wrede R von, Surges R (2021) Transcutaneous vagus nerve stimulation in the treatment of drug-resistant epilepsy. Auton Neurosci 235:102840.
• Wrede R von, Moskau-Hartmann S, Amarell N, Surges R, Erich Elger C, Helmstaedter C (2020) Plant derived versus synthetic cannabidiol: Wishes and commitment of epilepsy patients. Seizure 80:92–95.
• Wrede R von, Moskau-Hartmann S, Baumgartner T, Helmstaedter C, Surges R (2020) Counseling of people with epilepsy via telemedicine: Experiences at a German tertiary epilepsy center during the COVID-19 pandemic. Epilepsy Behav 112:107298.
• Wrede R von, Moskau-Hartmann S, Amarell N, Elger CE, Helmstaedter C (2019) Knowledge, expectations and fears of cannabis use of epilepsy patients at a tertiary epilepsy center. Epilepsy Behav 99:106458.
• Wrede R von, Moskau-Hartmann S, Rüber T, Helmstaedter C, Surges R (2019) Sustained seizure freedom with transcutaneous vagal nerve stimulation in drug-resistant epilepsy caused by subcortical band heterotopias. Seizure 70:25–26.
• Müller I, Elger CE, Wrede R von (2009) Social aspects in epilepsy: educational, employment and social situation in patients with epilepsy. Abstracts of the 6th Joint Meeting of the German, Austrian, and Swiss Sections of the International League Against Epilepsy. Epilepsia 50:43.