Publikationen

PubMed - Publikationen aus der Klinik

Molekulare Kopf-Hals-Onkologie

• Dietrich D, Weider S, de Vos L, Vogt TJ, Färber M, Zarbl R, Hunecke A, Glosch AK, Gabrielpillai J, Bootz F, Bauernfeind FG, Kramer FJ, Kristiansen G, Brossart P, Strieth S, Franzen A. Circulating Cell-Free SEPT9 DNA Methylation in Blood Is a Biomarker for Minimal Residual Disease Detection in Head and Neck Squamous Cell Carcinoma Patients. Clin Chem 2023, 69(9):1050-1061 (JIF: 8,3)
• Gül D, Schweitzer A, Khamis A, Knauer SK, Ding GB, Freudelsperger L, Karampinis I, Strieth S, Hagemann J, Stauber RH:
  Impact of Secretion-Active Osteoblast-Specific Factor 2 in Promoting Progression and Metastasis of Head and Neck Cancer.
  Cancers (Basel). 2022, 14:2337 (JIF: 6,639)
• Loick SM, Fröhlich A, Gabrielpillai J, Franzen A, Vogt TJ, Dietrich J, Wiek C, Scheckenbach K, Strieth S, Landsberg J, Dietrich D:
  DNA Methylation and mRNA Expression of OX40 (TNFRSF4) and GITR (TNFRSF18, AITR) in Head and Neck Squamous Cell Carcinoma Correlates With HPV Status, Mutational Load, an Interferon-γ Signature, Signatures of Immune Infiltrates, and Survival.
  J Immunother 2022, 45:194-206 (JIF: 4,912)
• Loick SM, Fröhlich A, Gabrielpillai J, Franzen A, Vogt TJ, Dietrich J, Wiek C, Scheckenbach K, Strieth S, Landsberg J, Dietrich D:
  DNA Methylation and mRNA Expression of OX40 (TNFRSF4) and GITR (TNFRSF18, AITR) in Head and Neck Squamous Cell Carcinoma Correlates With HPV Status, Mutational Load, an Interferon-γ Signature, Signatures of Immune Infiltrates, and Survival.
  J Immunother 2022, 45:194-206 (JIF: 4,912)
• Gül D, Habtemichael N, Dietrich D, Dietrich J, Gößwein D, Khamis A, Deuss E, Künzel J, Schneider G, Strieth S, Stauber RH:
  Identification of cytokeratin24 as a tumor suppressor for the management of head and neck cancer.
  Biol Chem 2021, 403(8-9):869-890 (JIF: 5,486)
• Bockhorst C, Dietrich J, Vogt TJ, Stauber RH, Strieth S, Bootz F, Dietrich D, Vos L:
  The DNA methylation landscape of PD-1 (PDCD1) and adjacent lncRNA AC131097.3 in head and neck squamous cell carcinoma.
  Epigenomics 2021, 13(2):113-127 (JIF: 4,778)
• Braun M, Aguilera AR, Sundarrajan A, Corvino D, Stannard K, Krumeich S, Das I, Lima LG, Meza Guzman LG, Li K, Li R, Salim N, Jorge MV, Ham S, Kelly G, Vari F, Lepletier A, Raghavendra A, Pearson S, Madore J, Jacquelin S, Effern M, Quine B, Koufariotis LT, Casey M, Nakamura K, Seo EY, Hölzel M, Geyer M, Kristiansen G, Taheri T, Ahern E, Hughes BGM, Wilmott JS, Long GV, Scolyer RA, Batstone MD, Landsberg J, Dietrich D, Pop OT, Flatz L, Dougall WC, Veillette A, Nicholson SE, Möller A, Johnston RJ, Martinet L, Smyth MJ, Bald T: CD155 on Tumor Cells Drives Resistance to Immunotherapy by Inducing the Degradation of the Activating Receptor CD226 in CD8+ T Cells. Immunity 2020, 53(4):805-823.e15 (JIF: 22,553)
• Vos L, Dietrich J, Strieth S, Bootz F, Dietrich D, Franzen A: PD-1, CTLA4, PD-L1 and PD-L2 DNA methylation in papillary thyroid carcinoma. Immunotherapy 2020, 12(12):903-920 (JIF: 2.964)
• de Vos L, Jung M, Koerber RM, Bawden EG, Holderried TAW, Dietrich J, Bootz F, Brossart P, Kristiansen G, Dietrich D: Treatment response monitoring in patients with advanced malignancies using cell-free SHOX2 and SEPT9 DNA methylation in blood: An observational prospective study. J Mol Diagn 2020, pii: S1525-1578(20)30299-3 (JIF: 4,426)
• de Vos L, Grünwald I, Bawden EG, Dietrich J, Scheckenbach K, Wiek C, Zarbl R, Bootz F, Landsberg J, Dietrich D: The landscape of CD28, CD80, CD86, CTLA4, and ICOS DNA methylation in head and neck squamous cell carcinomas. Epigenetics 2020, 21:1-18 (JIF: 4,173)
• Sailer V, Sailer U, Bawden EG, Zarbl R, Wiek C, Vogt TJ, Dietrich J, Loick S, Grünwald I, Toma M, Golletz C, Gerstner A, Kristiansen G, Bootz F, Scheckenbach K, Landsberg J, Dietrich D: DNA methylation of indoleamine 2,3-dioxygenase 1 (IDO1) in head and neck squamous cell carcinomas correlates with IDO1 expression, HPV status, patients' survival, immune cell infiltrates, mutational load, and interferon ã signature. EBioMedicine 2019, 48:341-352 (JIF: 6,490)
• Jung M, Ellinger J, Gevensleben H, Syring I, Lüders C, de Vos L, Pützer S, Bootz F, Landsberg J, Kristiansen G, Dietrich D: Cell-Free SHOX2 DNA Methylation in Blood as a Molecular Staging Parameter for Risk Stratification in Renal Cell Carcinoma Patients: A Prospective Observational Cohort Study. Clin Chem 2019, 65(4):559-568 (JIF: 6,891)
• Vogt TJ, Gevensleben H, Dietrich J, Kristiansen G, Bootz F, Landsberg J, Goltz D, Dietrich D:
  Detailed analysis of adenosine A2a receptor (ADORA2A) and CD73 (5'-nucleotidase, ecto, NT5E) methylation and gene expression in head and neck squamous cell carcinoma patients. Oncoimmunology 2018, 7(8): e1452579 (JIF: 5,333)
• Bergheim J, Semaan A, Gevensleben H, Groening S, Knoblich A, Dietrich J, Weber J, Kalff JC, Bootz F, Kristiansen G, Dietrich D: Potential of quantitative SEPT9 and SHOX2 methylation in plasmatic circulating cell-free DNA as auxiliary staging parameter in colorectal cancer: a prospective observational cohort study. Br J Cancer 2018, 118(9):1217-1228 (JIF: 5,416)
• Goltz D, Gevensleben H, Dietrich J, Schroeck F, de Vos L, Droege F, Kristiansen G, Schroeck A, Landsberg J, Bootz F, Dietrich D:
  PDCD1 (PD-1) promoter methylation predicts outcome in head and neck squamous cell carcinoma patients.
  Oncotarget 2017, 8(25):41011-41020 (JIF: 5,168)
• Franzen A, Vogt TJ, Müller T, Dietrich J, Schröck A, Golletz C, Brossart P, Bootz F, Landsberg J, Kristiansen G, Dietrich D:
  PD-L1 (CD274) and PD-L2 (PDCD1LG2) promoter methylation is associated with HPV infection and transcriptional repression in head and neck squamous cell carcinomas.
  Oncotarget 2017, 9(1):641-650 (JIF: 5,168)
• Schröck A, Leisse A, de Vos L, Gevensleben H, Dröge F, Franzen A, Wachendörfer M, Schröck F, Ellinger J, Teschke M, Wilhelm-Buchstab T, Landsberg J, Holdenrieder S, Hartmann G, Field JK, Bootz F, Kristiansen G, Dietrich D: Free-Circulating Methylated DNA in Blood for Diagnosis, Staging, Prognosis, and Monitoring of Head and Neck Squamous Cell Carcinoma Patients: An Observational Prospective Cohort Study. Clin Chem 2017, 63(7):1288-1296 (JIF: 6,891)
• Schröck A, Leisse A, de Vos L, Gevensleben H, Dröge F, Franzen A, Wachendörfer M, Schröck F, Ellinger J, Teschke M, Wilhelm-Buchstab T, Landsberg J, Holdenrieder S, Hartmann G, Field JK, Bootz F, Kristiansen G, Dietrich D: Free-Circulating Methylated DNA in Blood for Diagnosis, Staging, Prognosis, and Monitoring of Head and Neck Squamous Cell Carcinoma Patients: An Observational Prospective Cohort Study. Clin Chem 2017, 63(7):1288-1296 (JIF: 6,891)
• Göke F, Franzen A, Hinz TK, Marek LA, Yoon P, Sharma R, Bode M, von Maessenhausen A, Lankat-Buttgereit B, Göke A, Golletz C, Kirsten R, Boehm D, Vogel W, Kleczko EK, Eagles JR, Hirsch FR, Van Bremen T, Bootz F, Schroeck A, Kim J, Tan AC, Jimeno A, Heasley LE, Perner S:
  FGFR1 Expression Levels Predict BGJ398 Sensitivity of FGFR1-Dependent Head and Neck Squamous Cell Cancers.
  Clin Cancer Res 2015, 21(19):4356-64 (JIF: 9,618)
• Kneip C, Schmidt B, Seegebarth A, Weickmann S, Fleischhacker M, Liebenberg V, Field JK, Dietrich D: SHOX2 DNA methylation is a biomarker for the diagnosis of lung cancer in plasma. J Thorac Oncol 2011, 6(10):1632-8 (JIF: 12,460)

Otologie

• Fröhlich L, Mollet JK, Salha A, Eichhorn KWG, Curthoys I, Dlugaiczyk J, Wagner L, Strieth S.: Electrical Vestibular Co-stimulation by Lateral Wall Cochlear Implant Electrode Arrays. Otol Neurotol 2026, 47(3):493-501 (JIF: 2.063)
• Ernst BP, Heinrich UR, Fries M, Meuser R, Rader T, Eckrich J, Stauber RH, Strieth S. Cochlear implantation impairs intracochlear microcirculation and counteracts iNOS induction in guinea pigs. Front Cell Neurosci 2023, 17:1189980. (JIF: 6,147)
• Mönnich AL, Strieth S, Bohnert A, Ernst BP, Rader T.
  The German hearing in noise test with a female talker: development and comparison with German male speech test.
  Eur Arch Otorhinolaryngol 2023, 280(7):3157-3169 (JIF: 1,660)
• Rader T, Waleka OJ, Strieth S, Eichhorn KWG, Bohnert A, Koutsimpelas D, Matthias C, Ernst BP.
  Hearing rehabilitation for unilateral deafness using a cochlear implant: the influence of the subjective duration of deafness on speech intelligibility.
  Eur Arch Otorhinolaryngol. 2023 Feb;280(2):651-659 (JIF: 1,660)
• Rader T, Waleka OJ, Strieth S, Eichhorn KWG, Bohnert A, Koutsimpelas D, Matthias C, Ernst BP:
  Hearing rehabilitation for unilateral deafness using a cochlear implant: the influence of the subjective duration of deafness on speech intelligibility.
  Eur Arch Otorhinolaryngol 2022 (JIF: 3,236; online ahead of print)
• Heinrich UR, Meuser R, Ernst BP, Schmidtmann I, Dietrich D, Stauber RH, Strieth S:
  Regulation of Endothelial Nitric Oxide Synthase in the Reticular Lamina of the Organ of Corti by a Nitric Oxide Donor.
  J Histochem Cytochem 2021, 69(11):731-739 (JIF: 2,370)
• Frenis K, Kalinovic S, Ernst BP, Kvandova M, Al Zuabi A, Kuntic M, Oelze M, Stamm P, Bayo Jimenez MT, Kij A, Keppeler K, Klein V, Strohm L, Ubbens H, Daub S, Hahad O, Kröller-Schön S, Schmeisser MJ, Chlopicki S, Eckrich J, Strieth S, Daiber A, Steven S, Münzel T:
  Long-Term Effects of Aircraft Noise Exposure on Vascular Oxidative Stress, Endothelial Function and Blood Pressure: No Evidence for Adaptation or Tolerance Development.
  Front Mol Biosci 2022, 8:814921 (JIF: 6,113)
• Eckrich J, Frenis K,  Rodriguez-Blanco G, Ruan Y, Jiang S,  Jimenez MTB, Kuntic M, Oelze M, Hahad O,  Li H, Gericke A, Steven S, Strieth S, von Kriegsheim A, Münzel T, Ernst BP, Daiber A.
  Aircraft noise exposure drives the activation of white blood cells and induces microvascular dysfunction in mice
  Redox Biol 2021 Jul 8;46:102063 (JIF: 11.799)
• Joiko J, Bohnert A, Strieth S, Soli SD, Rader T:
  The German Hearing in Noise Test.
  Int J Audiol,  2020, Oct 29:1-7. (JIF: 1.759)
• Heinrich UR, Schmidtmann I, Meuser R, Ernst BP, Wünsch D, Siemer S, Gribko A, Stauber RH, Strieth S:
  Early Alterations of Endothelial Nitric Oxide Synthase Expression Patterns in the Guinea Pig Cochlea After Noise Exposure.
  J Histochem Cytochem 2019, 67(11):845-855 (JIF: 2,730)
• Plesch J, Ernst BP, Strieth S, Rader T: A psychoacoustic application for the adjustment of electrical hearing thresholds in cochlear implant patients.
  PLoS One 2019, 14(10):e0223625 (JIF: 2,776)
• Heinrich UR, Strieth S, Schmidtmann I, Stauber R, Helling K:
  Dexamethasone prevents hearing loss by restoring glucocorticoid receptor(GR)-expression in the lateral wall of the guinea pig cochlea.
  Laryngoscope 2016; 126:E29-34. (JIF: 2,471)
• Heinrich UR, Schmidtmann I, Strieth S, Helling K:
  Cell-specific accumulation patterns of gentamicin in the guinea pig cochlea.
  Hear Res 2015; 326:40-8. (JIF: 2,906)
• Arpornchayanon W, Canis M, Ihler F, Settevendemie C, Strieth S:
  TNF-α inhibition using etanercept prevents noise-induced hearing loss by improvement of cochlear blood flow in vivo.
  Int J Audiol 2013, 52:545-52. (JIF: 1,116)
• Arpornchayanon W*, Canis M*, Suckfuell M, Ihler F, Olzowy B, Strieth S: Modeling the measurements of cochlear microcirculation and hearing function after loud noise. [*contributed equally to this study]
  Otolaryngol Head Neck Surg 2011, 145:463-9 (JIF: 2,276)
• Scherer EQ, Yang J, Canis M, Reimann K, Ivanov K, Diehl CD, Backx PH, Wier WG, Strieth S, Wangemann P, Voigtlaender-Bolz J, Lidington D, Bolz SS: Tumor necrosis factor-α enhances microvascular tone and reduces blood flow in the cochlea via enhanced sphingosine-1-phosphate signaling.
  Stroke 2010, 41:2618-24 (JIF: 6,032)

Klinische Studien

• Köksal M, Saur L, Scafa D, R Sarria G, Leitzen C, Schmeel C, Far F, Strieth S, Giordano FA:
  Late toxicity-related symptoms and fraction dose affect decision regret among patients receiving adjuvant radiotherapy for head and neck cancer.
  Head Neck 2022, 44:1885-1895 (JIF: 3,147)
• Strieth S, Ernst BP, Both I, Hirth D, Pfisterer LN, Künzel J, Eder K: Randomized controlled single-blinded clinical trial of functional voice outcome after vascular targeting KTP-laser microsurgery of early laryngeal cancer.
  Head Neck 2019,41:899-907 (JIF: 3,376)
• Ernst BP, Hodeib M, Strieth S, Künzel J, Bischof F, Hackenberg B, Huppertz T, Weber V, Bahr K, Eckrich J, Hagemann J, Engelbarts M, Froelich MF, Solbach P, Linke R, Matthias C, Sommer WH, Becker S:
  Structured reporting of head and neck ultrasound examinations.
  BMC Med Imaging 2019, 19:25 (JIF: 1,622)
• Send T, Tuleta I, Koppen T, Thiesler T, Bertlich M, Bootz F, Jakob M: Sarcoidosis of the paranasal sinuses
  European Archives of Oto-Rhino-Laryngology 2019, 276(7):1969-1974 (JIF: 1,750)
• Send T, Bertlich M, Eichhorn K, Bootz F, Jakob M: Management and follow-up results of salivary fistulas treated with botulinumtoxin
  Laryngoscope 2019 Feb;129(2):403-408 (JIF: 2,442)
• Freytag M, Herrlinger U, Hauser S, Bauernfeind F, Gonzalez-Carmona M, Landsberg J, Buermann J,Vatter H, Holderried T, Send T, Schumacher M, Koscielny A, Feldmann G, Skowasch D, Heine M, Schäfer N, Funke B, Neumann M,Schmidt-Wolf I:
  Higher number of multidisciplinary tumor board meetings per case leads to improved clinical outcome: A matched pair analysis
  BMC Cancer 2019, 20(1):355 (JIF: 3,288)
• Rader T, Bohnert A, Matthias C, Koutsimpelas D, Kainz MA, Strieth S:
  Hearing preservation in children with electric-acoustic stimulation after cochlear implantation: Outcome after electrode insertion with minimal insertion trauma.
  HNO 2018, 66 (Suppl 2):56-62. (JIF: 0,723)
• Gabrielpillai J, Burck I, Baumann U, Stöver T, Helbig S: Incidence for Tip Foldover During Cochlea Implantation. Otol Neurotol 2018, 39(9):1115-1121 (JIF: 2.063)
• Eichhorn K, Westphal R, Rilk M,Last C, Bootz F, Wahl F, Jakob M, Send T: Robot-assisted endoscope guidance versus manual endoscope guidance in functional endonasal sinus surgery (FESS).
  Acta Otolaryngol 2017,137(10):1090-1095 (JIF 1,286)
• Strieth S, Dunau C, Michaelis U, Jäger, L, Gellrich D, Wollenberg B, Dellian M: Phase I/II clinical study on safety and antivascular effects of paclitaxel encapsulated in cationic liposomes for targeted therapy in advanced head and neck cancer.
  Head Neck 2014, 36:976-84. (JIF: 3,376)
• Strieth S, Siedek V*, Rytvina M, Gürkov R, Berghaus A, Clevert DA*: Dynamic contrast-enhanced ultrasound for differential diagnosis of submandibular gland disease. [*contributed equally to this study]
  Eur Arch Otorhinolaryngol 2014, 271:163-9. (JIF: 1,660)
• Strieth S, Dunau C, Kolbow K, Knuechel R, Michaelis U, Ledderose H, Eichhorn ME, Strelczyk D, Tschiesner U, Wollenberg B, Dellian M:
  Phase I clinical study of vascular targeting fluorescent cationic liposomes in head and neck cancer.
  Eur Arch Otorhinolaryngol 2013, 270:1481-7. (JIF: 1,660)
• Suckfuell M, Canis M, Strieth S, Scherer H, Haisch H:
  Intratympanic treatment of acute acoustic trauma with a cell-permeable JNK ligand: a prospective randomized phase-I/II study.
  Acta Otolaryngol 2007, 127:938-42. (JIF: 1,116)

• Müller A, Blümer M, Dziemba OC, Elsholz A, Fröhlich L, Hoppe U, Polterauer D, Rahne T, Steffens T, Walger M, Weißgerber T, Wesarg T, Zirn S, Rader T: Recommendations for selection of target parameters and process recommendations for audiological and technical functional testing of cochlear implant : Prepared by the ERA consortium (AG-ERA) of ADANO in cooperation with the Implantable Hearing Systems expert committee of the DGA. Confirmed by the board of ADANO on 31.01.2025. HNO 2025, 73(Suppl 3):348-356

• Strieth S, Hagemann J, Hess M:
  [Angiolytic laser applications for the larynx : Phonosurgical concepts for transoral laser microsurgery].
  HNO 2020, 68:59-68 (JIF: 1.000)

• Dietrich D: [FGFR-targeted therapy in head and neck carcinomas].
  HNO 2020, online ahead of print (JIF: 1.000)

• Stöver T, Dazert S, Hoffmann TK, Plontke SK, Ambrosch P, Arens C, Betz C, Beutner D, Bohr C, Bruchhage KL, Canis M, Dietz A, Guntinas-Lichius O, Hagen R, Hosemann W, Iro H, Klussmann JP, Knopf A, Kramer S, Lang S, Leinung M, Lenarz T, Löwenheim H, Matthias C, Mlynski R, Olze H, Park J, Plinkert P, Radeloff A, Rotter N, Rudack C, Bozzato A, Schipper J, Schrader M, Strieth S, Stuck BA, Volkenstein S, Westhofen M, Wolf G, Wollenberg B, Zahnert T, Zenk J:
  [Effects of the SARS-CoV-2 pandemic on the otorhinolaryngology university hospitals in the field of medical care].
  Laryngorhinootologie 2020, 99(10):694-706  (JIF: 0.922)

• Klimek L, Bachert C, Pfaar O , Sven Becker S , Bieber T , Brehler R , Buhl  R , Casper  I , Adam Chaker  A , Wolfgang Czech  W , Jörg Fischer J , Thomas Fuchs T , Michael Gerstlauer M , Karl Hörmann K , Thilo Jakob T , Kirsten Jung K , Kopp MV, Mahler V , Merk H , Norbert Mülleneisen  N , Katja Nemat  K , Uta Rabe U, Johannes Ring  J , Joachim Saloga  J , Wolfgang Schlenter  W , Carsten Schmidt-Weber  C , Holger Seyfarth  H , Annette Sperl  A , Thomas Spindler  T , Petra Staubach  P , Strieth  S , Treudler  R , Vogelberg  C, Wallrafen A , Wehrmann  W , Wrede  H , Zuberbier T, Bedbrook A , Canonica  GW , Cardona  V, Casale  TB , Czarlewski W , Fokkens  WJ , Hamelmann  E, Jutel  M , Larenas-Linnemann D, Mullol J , Papadopoulos NG , Toppila-Salmi S , Werfel  T , Bousquet J:
  ARIA guideline 2019: treatment of allergic rhinitis in the German health system
  Allergol Select 2019, 30,3(1): 22-50

• Klimek L, Chaker AM, Casper I, Sperl A, Strieth S, Mösges R.
  [Therapy of Allergies and Allergy Immunotherapy in Children].
  Laryngorhinootologie 2020, 99(1):56-66 (JIF: 0.922)

• Leggewie B, Zimmermann A, Strieth S, Gouveris H:
  [Systemic and local therapy options for sudden sensorineural hearing loss in diabetics].
  HNO 2019 67:639-648 (JIF: 0,914)

• Stauber RH Siemer S; Becker S, Ding GB; Strieth S, Knauer S:
  Small meets smaller: effects of nanomaterials on microbial biology, pathology, and ecology.
  ACS Nano 2018, 12:6351-6359 (JIF: 13,903)

• Beltz A, Gösswein D, Zimmer S, Stauber RH, Hagemann J, Strieth S, Matthias C, Künzel J:
  [Staging of oropharyngeal carcinomas: New TNM classification as a challenge for head and neck cancer centers].
  HNO 2018, 66(5):375-3 (JIF: 0,914)

• Künzel J, Strieth S, Wirth G, Bozzato A:
  Ultrasound in the re-staging of cervical metastases after chemoradiotherapy for head and neck cancer.
  Ultraschall in Med 2018, 39:659-666 (JIF: 4,613)