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Focus on hemostasis – Prof. J. Müller, Prof. B. Pötzsch, Prof. H. Rühl

Leitung / Group leaders

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Prof. Dr. Jens Müller

 

Tel: 0228-287 16735

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Prof Bernd Poetzsch Poertrait IHT

Univ.-Prof. Dr. Bernd Pötzsch

Tel: 0228-287 16745

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PD Dr. med. Dipl.-Kfm. Heiko Rühl

Prof. Dr. Heiko Rühl

 

Tel: 0228-287 16753

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  • Identification of coagulation factor-binding ligands and their application
  • Development and evaluation of diagnostic methods in specialized coagulation testing
  • Studies on the variable expressivity of the factor V Leiden mutation
  • Deep hemostasis profiling in COVID-19
  • Factors influencing effectiveness testing of antiplatelet therapy via whole-blood assays
  • Cellular characterization of leukapheresis products
  • Generation of chimeric antigen receptor cells from cryopreserved peripheral blood stem cell units for lymphoma treatment
  • Impact of allogenic red blood cell transfusions on treatment response to checkpoint inhibitor therapy in cancer patients
  • Characterization of hereditary and situational risk factors for venous thrombosis in atypical sites
  • Characterization of hemostasis activation in splanchnic vein thrombosis
  • Comparative studies on the influence of oral anticoagulant drugs on the biomarkers D-dimer and prothrombin fragment 1+2
  • Significance of thrombophilia testing in clinical decision-making
  • Disease-modulating role of the endothelium in factor V Leiden thrombophilia

Core team

  • Simone Gasper
  • Hannah L. McRae
  • PD Dr. Sara Reda
  • Nadine Schwarz
  • Dr. Marcus Wagner

MD candidates

  • Johanna Busse
  • Sebastian Eckert
  • Markus Horchler
  • Dalia Khaddam
  • Johannes Klee
  • Eva Maria Klein
  • Yuliya Krauchuk
  • Eva Rudde

Off-site

  • Institute of Aerospace Medicine, Medical Faculty, University of Cologne
  • Department of Anesthesiology and Intensive Care Medicine, Merheim Medical Center, University of Witten/Herdecke
  • Department of Cardiac Surgery, Albertinen Heart Center, Hamburg
  • Department of Cardiology, Angiology and Pneumology, University of Heidelberg
  • Institute for Clinical Immunology and Transfusion Medicine, Justus Liebig University, Gießen
  • Institute for Clinical and Experimental Transfusion Medicine, Medical Faculty of Tübingen, University Hospital of Tübingen
  • Department of Clinical Pharmacy, Division Laboratories, Pharmacy and Biomedical Genetics, University Medical Center Utrecht
  • Institute for Immunology and Transfusion Medicine, Ernst Moritz Arndt University Greifswald
  • LOXO / ImmBioMed, Heidelberg
  • Department of Neurology, Amsterdam University Medical Centers, University of Amsterdam
  • Institute for Organic Chemistry and Chemical Biology, Goethe University Frankfurt
  • Department of Pediatrics and Adolescent Medicine, Clinical and Molecular Hemostasis, Goethe University Frankfurt
  • Department of Pharmacy, Thrombosis and Hemostasis Center (NTHC), Namur Research Institute for Life Sciences, University of Namur
  • Translational Immunology, Department of Biomedicine, University of Basel
  • Institute for Transplantation Diagnostics and Cell Therapeutics, Heinrich-Heine University, Düsseldorf

University Bonn

  • Center of Aptamer Research & Development, Life and Medical Sciences Institute (LIMES)
  • Department of Cardiovascular Surgery
  • Department of Gynecology and Obstetrics
  • Institute of Human Genetics
  • Department of Internal Medicine I
  • Department of Internal Medicine II for Cardiology, Angiology and Pneumology
  • Department of Internal Medicine III for Oncology, Hematology and Rheumatology
  • Institute for Medical Microbiology, Immunology and Parasitology
  • Department of Neurology
  • Department of Obstetrics and Prenatal Medicine
  • Department of Orthodontics, Center of Dento-Maxillo-Facial Medicine
  • Department of Orthopedics and Trauma Surgery
  • Pharmaceutical Biochemistry and Bioanalytics, Pharmaceutical Institute
  • Department of Pharmacy
  • Clinic for Psychosomatic Medicine and Psychotherapy
  • Kuanyshbek A, Yadegari H, Müller J, Hamedani NS, Ramaraje SU, Oldenburg J. Interplay between circulating von Willebrand factor and neutrophils: implications for inflammation, neutrophil function, and von Willebrand factor clearance. Haematologica. 2025 Jan 9
  • Reda S, Chang J, Busse J, Schwarz N. McRae HL, Müller J, Strassburg CP, Oldenburg J, Pötzsch B, Jansen C, Rühl H. Assessment of Hypercoagulability in Splanchnic Vein Thrombosis by Measurement of the Hemostasis Enzymes Thrombin and Activated Protein C. Int J Mol Sci. 2024; 26: 292
  • Pezeshkpoor B, Fischer R, Preisler B, Hartlieb K, Rühl H, Müller J, Horneff S, Marquardt N, Pavlova A, Oldenburg J. Modulation of Haemostatic Balance in Combined von Willebrand Disease and Antithrombin Deficiency: A Comprehensive Family Study. Haemophilia. 2024 Dec 19
  • McRae HL, Müller J, Rühl H, Pötzsch B. Impact of Thrombophilia Testing on Clinical Magament: A Retrospective Cohort Study. Hamostaseologie. 2024 Dec 10.
  • Rühl H, Bode C, Becher T, Eckert S, Mohsen G, McRae HL, Müller J, Reda S, Loßnitzer D, Oldenburg J. Decreased Protein C Pathway Activity in COVID-19 Compared to Non-COVID Sepsis: An Observational and Comparative Cohort Study. Biomedicines. 2024; 12: 1982
  • Müller J, Albert T, Klein C, Horneff S, Rühl H, Pötzsch B, Goldmann G, Marquardt N, Oldenburg J. Comprehensive laboratory assessment of lonoctocog alfa versus octocog alfa in severe haemophilia A. Haemophilia. 2024; 30: 1203-1209.
  • Krahforst A, Yadegari H, Pavlova A, Pezeshkpoor B, Müller J, Pötzsch B, Scholz U, Richter H, Trobisch H, Liebscher K, Olivieri M, Trautmann-Grill K, Knöfler R, Halimeh S, Oldenburg J. Unravelling the spectrum of von Willebrand factor variants in quantitative von Willebrand disease: results from a German cohort study. J Thromb Haemost. 2024: 22: 3010-3034.
  • Hopp MT, Vaidya SM, Grimmig KM, Strudthoff LJ, Clauser JC, Yuan X, Singh S, Müller J, Oldenburg J, Hamza I, Imhof D. Quantitative analysis of heme and hemoglobin for the detection of intravascular hemolysis. Anal Chim Acta. 2024; 1312: 342766.
  • Khaddam D, McRae HL, Schwarz N, Oldenburg J, Pötzsch B, Rühl H, Reda S. High prevalence of F2 20210G>A in splanchnic vein thrombosis and cerebral venous sinus thrombosis – a retrospective cohort study of patients with thrombosis in atypical sites. Hamostaseologie. 2024 Jun 26.
  • Pezeshkpoor B, Berkemeier AC, Herbst K, Albert T, Müller J, Oldenburg J. Comprehensive domain-specific analysis and immunoglobulin G profiling of anti-factor VIII antibodies using a bead-based multiplex immunoassay. J Thromb Haemost. 2024; 22: 1591-1604.
  • Reda S, Schwarz N, Müller J, McRae HL, Oldenburg J, Pötzsch B, Rühl H. Fibrinolysis biomarker, thrombin, and activated protein C level alterations after coagulation activation depend on type of thrombophilia and clinical phenotype. Res Pract Thromb Haemost. 2024; 8: 102351.
  • Preisler B, Pezeshkpoor B, Merzenich A, Ohlenforst S, Rühl H, Ivaškevičius V, Scholz U, Bönigk H, Eberl W, Zieger B, Pavlova A, Oldenburg J. Genetic Landscape of Factor VII Deficiency: Insights from a Comprehensive Analysis of Pathogenic Variants and their Impact on Coagulation Activtiy. Int J Mol Sci. 2024; 25: 2384.
  • Didembourg M, Reda S, Oldenburg J, Rühl H, Douxfils J, Morimont, L. Hemostatic imbalance induced by tamoxifen in estrogen receptor-positive breast cancer patients: an observational study. Int J Lab Hematol. 2024; 46: 546-554.
  • Müller J, Neimanis S, Kahle J, Albert T, Schultze Strasser S, Rup B, Pötzsch B, Königs C, Oldenburg J; ABIRISK Consortium. Two-center validation of assays for the detection of binding and neutralizing anti-factor VIII antibodies. Haemophilia. 2024; 30: 224-231.
  • Ayub TH, Strizek B, Poetzsch B, Kosian P, Gembruch U, Merz WM. Placenta Accreta Spectrum Prophylactic Therapy for Hyperfibrinolysis with Tranexamic Acid. J Clin Med. 2023; 13: 135.
  • Hamedani NS, Donners AAMT, van Luin M, Gasper S, Rühl H, Klein C, Albert T, el Amrani M, Pötzsch B., Oldenburg J, Müller J. Functional determination of emicizumab in presence of factor VIII activity. J Thromb Haemost. 2023; 21: 3490-3500.
  • Ivaškevičius V, Biswas A, Singh S, Stulpinaite U, Reda S, Rühl H, Pezeshkpoor B, Pavlova A, Oldenburg J. Fibrinogen Bonn (p. Arg510Cys) in the Aα-Chain Is Associated with High Risk of Venous Thrombosis. Hamostaseologie. 2023; 43: 440-446.
  • Schwarz N, Müller J, Yadegari H, McRae HL, Reda S, Hamedani NS, Oldenburg J, Pötzsch B, Rühl H. Ex Vivo Modeling of the PC (Protein C) Pathway Using Endothelial Cells and Plasma: A Personalized Approach. Arterioscler Thromb Vasc Biol. 2023; 43: 109-119.
  • Tschuertz N, Kupczyk P, Poetzsch B, Gembruch U, Merz WM. Unilateral Non-Hemorrhagic Adrenal Infarction in Pregnancy: Case Series and Literature Review. J Clin Med. 2023; 12: 4855.
  • Caspers M, Schäfer N, Bouillon B, Schaeben V, Ciorba MC, Maegele M, Müller J, Pötzsch B. Plasmatic coagulation profile after major traumatic injury: a prospective observational study. Eur J Trauma Emerg Surg. 2022; 48: 4595-4606.
  • Reda S, Rudde E, Müller J, Hamedani NS, Oldenburg J, Pötzsch B, Rühl H. Variation in plasma levels of apixaban and rivaroxaban in clinical routine treatment of venous thromboembolism. Life (Basel). 2022; 12: 705.
  • Reda S, Thiele Serra E, Müller J, Hamedani NS, Oldenburg J, Pötzsch B, Rühl H. Increased Prevalence of Elevated D-dimer Levels in Patients on Direct Oral Anticoagulants: Results of a Large Retrospective Study. Front Cardiovasc Med. 2022; 9: 830010.
  • Becher T, Schimanski R, Müller J, Baumann S, Klenantz S, Pötzsch B, Lossnitzer D. Plasma levels of thrombin and activated protein C in patients with acute myocardial Infarction: An observational study. Int J Cardiol Heart Vasc. 2022; 42: 101097.
  • Hirsiger JR, Martinez M, Tsakiris DA, Cittone MG, Graf L, Oldenburg J, Pezeshkpoor B, Recher M, Mueller J, Gerber B, Berger CT. Investigating potential mechanisms underlying FVIII inhibition in acquired hemophilia A associated with mRNA COVID-19 vaccines. J Thromb Haemost. 2022; 20: 1015-1018.
  • Négrier C, Oldenburg J, Kenet G, Meeks SL, Bordet JC, Müller J, Le Quellec S, Turecek PL, Tripkovic N, Dargaud Y. Recombinant porcine factor VIII corrects thrombin generation in vitro in plasma from patients with congenital hemophilia A and inhibitors. Res Pract Thromb Haemost. 2022; 6: e12731.
  • Müller J, Hamedani NS, McRae HL, Rühl H, Oldenburg J, Pötzsch B. Assay for ADAMTS-13 Activity with Flow Cytometric Readout. ACS Omega. 2022; 7: 30801-30806.
  • Hamedani NS, Happich FL, Klein EM, Rühl H, Mayer G, Oldenburg J, Müller J, Pötzsch B. Aptamer loaded superparamagnetic beads for selective capturing and gentle release of activated protein C. Sci Rep. 2022; 12: 7091.
  • Krzywicka K, van de Munckhof A, Zimmermann J, Bode FJ, Frisullo G, Karapanayiotides T, Pötzsch B, Sánchez van Kammen M, Heldner MR, Arnold M, Kremer Hovinga JA, Ferro JM, Aguiar de Sousa D, Coutinho JM. Cerebral venous thrombosis due to vaccine-induced immune thrombotic thrombocytopenia after a second ChAdOx1 nCoV-19 dose. Blood. 2022; 139: 2720-2724.
  • Hamedani NS, Oldenburg J, Pötzsch B, Müller J. Optimization and evaluation of a two-stage chromogenic assay procedure for measurement of emicizumab plasma levels. PLoS One. 2022; 17: e0271330.
  • Reda S, Schwarz N, Müller J, Oldenburg J, Pötzsch B, Rühl H. Impaired in vivo activated protein C response rates indicate a thrombophilic phenotype in inherited thrombophilia Haematologica. 2022; 107: 1197-1200.
  • Yadegari H, Jamil MA, Müller J, Marquardt N, Rawley O, Budde U, El-Maarri O, Lillicrap D, Oldenburg J. Multifaceted pathomolecular mechanism of a VWF large deletion involved in the pathogenesis of severe VWD. Blood Adv. 2022; 6: 1038-1053.
  • Hejazi M, Zhang C, Bennstein SB, Balz V, Reusing SB, Quadflieg M, Hoerster K, Heinrichs S, Hanenberg H, Oberbeck S, Nitsche M, Cramer S, Oberoi P, Rühl H, Oldenburg J, Brossart P, Horn PA, Babor F, Wels WS, Fischer JC, Möker N, Uhrberg M. CD33 delineates two functionally distinct NK cell populations divergent in cytokine production and antibody-mediated cellular cytotoxicity. Front Immunol. 2022; 12: 798087.
  • Ghosh S, Kraus K, Biswas A, Müller J, Forin F, Singer H, Höning K, Hornung V, Watzka M, Oldenburg J, Czogalla-Nitsche KJ. GGCX variants leading to biallelic deficiency to γ-carboxylate GRP cause skin laxity in VKCFD1 patients. Hum Mutat. 2022; 43: 42-55.
  • Saleh M, Zimmermann J, Lehnen NC, Pötzsch B, Weller JM. Late-Onset Vaccine-Induced Immune Thombotic Thrombocytopenia (VITT) with Cerebral Venous Sinus Thrombosis. J Stroke Cerebrovasc Dis. 2022; 31: 106311.
  • Rühl H, Friemann AM, Reda S, Schwarz N, Winterhagen FI, Berens C, Müller J, Oldenburg J, Pötzsch B. Activated factor XI is increased in plasma in response to surgical trauma but not to recombinant activated factor VII-induced thrombin formation. J Atheroscler Thromb. 2022; 29: 82-98.
  • Oezkur M, Reda S, Rühl H, Theuerkauf N, Charitos E, Silaschi M, Medina M, Zimmer Z, Treede H. Role of Acquired von Willebrand Syndrome in the Development of Bleeding Complications in Patients Treated with Impella RP Devices. Sci Rep. 2021; 11: 23722.
  • Sugiura A, Treiling L, Al-Kassou B, Shamekhi J, Wilde N, Sinning JM, Zimmer S, Kuetting D, Oldenburg J, Poetzsch B, Nickenig G, Sedaghat A. Spleen Size and Thrombocytopenia After Transcatheter Aortic Valve Implantation. Am J Cardiol. 2021; 157: 85-92.
  • Reda S, Müller J, Pavlova A, Pezeshkpoor B, Oldenburg J, Pötzsch B, Rühl H. Functional characterization of antithrombin mutations by monitoring of thrombin inhibition kinetics. Int J Mol Sci. 2021; 22: 2119
  • Reda S, Rühl H, Witkowski J, Müller J, Pavlova A, Oldenburg J, Pötzsch B. PC Deficiency Testing: Thrombin-Thrombomodulin as PC Activator and Aptamer-based Enzyme Capturing Increase Diagnostic Accuracy. Front Cardiovasc Med. 2021; 8: 755281.
  • Preisler B, Pezeshkpoor B, Banchev A, Fischer R, Zieger B, Scholz U, Rühl H, Kemkes-Matthes B, Schmitt U, Redlich A, Unal S, Laws HJ, Olivieri M, Oldenburg J, Pavlova A. Familial multiple coagulation factor deficiencies (FMCFDs) in a large cohort of patients – a single center experience in genetic diagnosis. J Clin Med. 2021; 10: 347.
  • Ghosh S, Kraus K, Biswas A, Müller J, Buhl AL, Forin F, Singer H, Höning K, Hornung V, Watzka M, Czogalla-Nitsche KJ, Oldenburg J. GGCX mutations show different responses to vitamin K thereby determining the severity of the hemorrhagic phenotype in VKCFD1 patients. J Thromb Haemost. 2021; 19: 1412-1424.
  • Müller P, Sahlbach M, Gasper S, Mayer G, Müller J, Pötzsch B, Heckel A. Controlling Coagulation in Blood with Red Light. Angew Chem Int Ed Engl. 2021; 60: 22441-22446.
  • Sharma A, Müller J, Schuetze K, Rolfes V, Bissinger R, Rosero N, Ahmad A, Franklin BS, Zur B, Fröhlich H, Lang F, Oldenburg J, Pötzsch B, Wüllner U. Comprehensive Profiling of Blood Coagulation and Fibrinolysis Marker Reveals Elevated Plasmin-Antiplasmin Complexes in Parkinson's Disease. Biology (Basel). 2021; 10: 716.
  • Sachs UJ, Cooper N, Czwalinna A, Müller J, Pötzsch B, Tiede A, Althaus K. PF4-Dependent Immunoassays in Patients with Vaccine-Induced Immune Thrombotic Thrombocytopenia: Results of an Interlaboratory Comparison. Thromb Haemost. 2021; 121: 1622-1627.
  • Althaus K, Möller P, Uzun G, Singh A, Beck A, Bettag M, Bösmüller H, Guthoff M, Dorn F, Petzold GC, Henkes H, Heyne N, Jumaa H, Kreiser K, Limpach C, Luz B, Maschke M, Müller JA, Münch J, Nagel S, Pötzsch B, Müller J, Schlegel C, Viardot A, Bäzner H, Wolf M, Pelzl L, Warm V, Willinek WA, Steiner J, Schneiderhan-Marra N, Vollherbst D, Sachs UJ, Fend F, Bakchoul T. Antibody-mediated procoagulant platelets in SARS-CoV-2-vaccination associated immune thrombotic thrombocytopenia. Haematologica. 2021; 106: 2170-2179.
  • Hamedani NS, Biswas A, Rudan O, Tönges R, Meyring C, Tolle F, Mayer G, Oldenburg J, Müller J, Pötzsch B. Functional and Structural Characterization of Nucleic Acid Ligands That Bind to Activated Coagulation Factor XIII. J Clin Med. 2021; 10: 677.
  • Hopp MT, Alhanafi N, Paul George AA, Hamedani NS, Biswas A, Oldenburg J, Pötzsch B, Imhof D. Molecular Insights and Functional Consequences of the Interaction of Heme with Activated Protein C. Antioxid Redox Signal. 2021; 34: 32-48.
  • Reda S, Brügelmann A, Müller J, Oldenburg J, Pötzsch B, Rühl H. Functional Lupus Anticoagulant Testing in a Large Retrospective Cohort of Thrombosis Patients with Direct Oral Anticoagulants. Sci Rep. 2020; 10: 12221
  • Berens C, Oldenburg J, Pötzsch B, Müller J. Glycophorin A-based exclusion of red blood cells for flow cytometric analysis of platelet glycoprotein expression in citrated whole blood. Clin Chem Lab Med. 2020; 58: 2081-2087.
  • Müller J, Goldmann G, Marquardt N, Pötzsch B, Oldenburg J. Extended Half-Life Factor VIII/Factor IX Products: Assay Discrepancies and Implications for Hemophilia Management. Hamostaseologie. 2020; 40 (S 01): S15-S20.
  • Limper U, Ahnert T, Maegele M, Froehlich M, Grau M, Gauger P, Bauerfeind U, Görlinger K, Pötzsch B, Jordan J. Simulated Hypergravity Activates Hemostasis in Healthy Volunteers. J Am Heart Assoc. 2020; 9: e016479.
  • Hamedani NS, Müller J, Tolle F, Rühl H, Pezeshkpoor B, Liphardt K, Oldenburg J, Mayer G, Pötzsch B. Selective modulation of the protease activated protein C using exosite inhibiting aptamers. Nucleic Acid Ther. 2020; 30: 276-288.
  • Becher T, Müller J, Akin I, Baumann S, Stach K, Borggrefe M, Pötzsch B, Loßnitzer D. Characterization of circulating thrombin in patients with septic shock: a prospective observational study. J Thromb Thrombolysis.2020; 50: 90-97.
  • Rühl H, Berens C, Winterhagen FI, Reda S, Müller J, Oldenburg J, Pötzsch B. Increased Activated Protein C Response Rates Reduce the Thrombotic Risk of Factor V Leiden Carriers but not of Prothrombin 20210G>A Carriers. Circ Res. 2019; 125: 523-534.
  • Buerfent BC, Gölz L, Hofmann A, Rühl H, Stamminger W, Fricker N, Hess T, Oldenburg J, Nöthen MM, Schumacher J, Hübner MP, Hoerauf A. Transcriptome-wide analysis of filarial extract-primed human monocytes reveal changes in LPS-induced PTC3 expression levels. Sci Rep. 2019; 9: 2562.
  • Bäuml CA, Schmitz T, Paul George AA, Sudarsanam M, Hardes K, Steinmetzer T, Holle LA, Wolberg AS, Pötzsch B, Oldenburg J, Biswas A, Imhof D. Coagulation Factor XIIIa Inhibitor Tridegin: On the Role of Disulfide Bonds for Folding, Stability, and Function. J Med Chem. 2019; 62: 3513-3523.
  • Rühl H, Winterhagen FI, Berens C, Müller J, Oldenburg J, Pötzsch B. In vivo thrombin generation and subsequent APC formation are increased in factor V Leiden carriers. Blood. 2018; 131: 1489-1492.
  • Rühl H, Reda S, Müller J, Oldenburg J, Pötzsch B. Activated Factor X-Based versus Thrombin-Based Antithrombin Testing in Thrombophilia Workup in the DOAC Era. Thromb Haemost. 2018; 118: 381-387.
  • Friedrich MJ, Schmolders J, Rommelspacher Y, Strauss A, Rühl H, Mayer G, Oldenburg J, Wirtz D, Müller J, Pötzsch B. Activity pattern analysis indicates increased but balanced systemic coagulation activity in response to surgical trauma. TH Open. 2018; 02: e350-356.
  • Becher T, Müller J, Akin I, Baumann S, Bosch K, Stach K, Borggrefe M, Pötzsch B, Loßnitzer D. The evolution of activated protein C plasma levels in septic shock and its association with mortality: A prospective observational study. J Crit Care. 2018; 47: 41-48.
  • Ponert JM, Schwarz S, Haschemi R, Müller J, Pötzsch B, Bendas G, Schlesinger M. The mechanisms how heparin affects the tumor cell induced VEGF and chemokine release from platelets to attenuate the early metastatic niche formation. PLoS One. 2018; 13: e0191303.
  • Böhmer AC, Gölz L, Kreusch T, Kramer FJ, Pötzsch B, Nöthen MM, Jäger A, Mangold E, Knapp M, Ludwig KU. Investigation of dominant and recessive inheritance models in genome-wide association studies data of nonsyndromic cleft lip with or without cleft palate. Birth Defects Res. 2018; 110: 336-341.
  • Schindewolf M, Steindl J, Beyer-Westendorf J, Schellong S, Dohmen PM, Brachmann J, Madlener K, Pötzsch B, Klamroth R, Hankowitz J, Banik N, Eberle S, Müller MM, Kropff S, Lindhoff-Last E. Use of Fondaparinux Off-Label or Approved Anticoagulants for Management of Heparin-Induced Thrombocytopenia. J Am Coll Cardiol. 2017; 70: 2636-2648.
  • Pezeshkpoor B, Schreck U, Biswas A, Driesen J, Berkemeier AC, Pavlova A, Müller J, Oldenburg J. An in silico and in vitro approach to elucidate the impact of residues flanking the cleavage scissile bonds of FVIII. PLoS One. 2017; 12: e0180456.
  • Geiser F, Urbach AS, Harbrecht U, Conrad R, Pötzsch B, Amann N, Kiesewetter K, Sieke A, Wolffs K, Skowasch D. Anxiety and depression in patients three months after myocardial infarction: Association with markers of coagulation and the relevance of age. J Psychosom Res. 2017; 99: 162-168.
  • Sedaghat A, Kulka H, Sinning JM, Falkenberg N, Driesen J, Preisler B, Hammerstingl C, Nickenig G, Pötzsch B, Oldenburg J, Hertfelder HJ, Werner N. Transcatheter aortic valve implantation leads to a restoration of von Willebrand factor (VWF) abnormalities in patients with severe aortic stenosis - Incidence and relevance of clinical and subclinical VWF dysfunction in patients undergoing transfemoral TAVI. Thromb Res. 2017; 151: 23-28.
  • Ivaškevičius V, Rühl H, Detarsio G, Biswas A, Gupta S, Davoli M, Quartara A, Pérez S, Raviola M, Oldenburg J. A novel missense mutation in the FGB gene (p.Gly302Arg) leading to afibrinogenemia. Predicted structure and function consequences. Hamostaseologie. 2016; 36 Supplement 2: S34-S37.
  • Sedaghat A, Falkenberg N, Sinning JM, Kulka H, Hammerstingl C, Nickenig G, Oldenburg J, Pötzsch B, Werner N. TAVI induces an elevation of hemostasis-related biomarkers, which is not causative for post-TAVI thrombocytopenia. Int J Cardiol. 2016; 221: 719-25.
  • Hamedani NS, Rühl H, Zimmermann JJ, Heiseler T, Oldenburg J, Mayer G, Pötzsch B, Müller J. In vitro evaluation of aptamer-based reversible inhibition of anticoagulant activated protein C as a novel supportive hemostatic approach. Nucleic Acid Ther. 2016; 26: 355-362.
  • Pezeshkpoor B, Castoldi E, Mahler A, Hanel D, Müller J, Hamedani NS, Biswas A, Oldenburg J, Pavlova A. Identification and functional characterization of a novel F5 mutation (Ala512Val, FVB onn ) associated with activated protein C resistance. J Thromb Haemost. 2016; 14: 1353-63.
  • Müller J, Becher T, Mayer G, Pötzsch B. Aptamer-Based Enzyme Capture Assay for Measurement of Plasma Thrombin Levels. Methods Mol Biol. 2016; 1380: 179-89.
  • Berens C, Heine A, Müller J, Held SAE, Mayer K, Brossart P, Oldenburg J, Pötzsch B, Wolf D, Rühl H. Variable resistance to freezing and thawing of CD34 positive stem cells and lymphocyte subpopulations in leukapheresis products. Cytotherapy. 2016; 18: 1325-1331.
  • Gölz L, Buerfent BC, Hofmann A, Rühl H, Fricker N, Stamminger W, Oldenburg J, Deschner J, Hoerauf A, Nöthen MM, Schumacher J, Hübner MP, Jäger A. Genome-wide transcriptome induced by nickel in human monocytes. Acta Biomater. 2016; 43: 369-382.
  • Merz WM, Rüland AM, Hippe V, Poetzsch B, Meyer C, Pollok JM, Gembruch U, Trebicka J. Pregnancy in Budd-Chiari Syndrome: Case Report and Proposed Risk Score. Medicine (Baltimore). 2016; 95: e3817.
  • Gölz L, Buerfent BC, Hofmann A, Hübner MP, Rühl H, Fricker N, Schmidt D, Oldenburg J, Jepsen S, Deschner J, Hoerauf A, Nöthen MM, Schumacher J, Jäger A. Genome-wide transcriptome induced by Porphyromonas gingivalis LPS supports the notion of host-derived periodontal destruction and its association with systemic diseases. Innate Immun. 2016; 22: 72-84.
  • Berens C, Rühl H, Ivaškevičius V, Oldenburg J, Hertfelder HJ, Pötzsch B. Recurrent VTE in a heterozygote of the fibrinogen Aα IVS4+1G>T and Aα p.Arg168Ter mutation. Thromb Haemost. 2016; 115: 1073-1075.
  • Rühl H, Berens C, Winterhagen A, Müller J, Oldenburg J, Pötzsch B. Label-Free Kinetic Studies of Hemostasis-Related Biomarkers Including D-dimer Using Autologous Serum Transfusion. PLoS One. 2015; 10: e0145012.
  • Caspers M, Czogalla KJ, Liphardt K, Müller J, Westhofen P, Watzka M, Oldenburg J. Two enzymes catalyze vitamin K 2,3-epoxide reductase activity in mouse: VKORC1 is highly expressed in exocrine tissues while VKORC1L1 is highly expressed in brain. Thromb Res. 2015; 135: 977-83.
  • Ivaškevičius V, Marquardt N, Horneff S, Klein C, Goldmann G, Rühl H, Pötzsch B, Oldenburg J. Neoplasm-induced bleeding in inherited, heterozygous FXIII-A deficiency. Hamostaseologie. 2015; 35 Supplement 1: S32-S35.
  • Ivaškevičius V, Thomas A, Biswas A, Ensikat H, Schmitt U, Horneff S, Pavlova A, Poetzsch B, Oldenburg J. A novel fibrinogen γ chain frameshift deletion (c.637delT) in a patient with hypodysfibrinogenemia associated with thrombosis. Hamostaseologie. 2015; 35 Suppl 1: S27-31.
  • Schröder L, Pötzsch B, Rühl H, Gembruch U, Merz WM. Tranexamic acid for hyperfibrinolytic hemorrhage during conservative management of placenta percreta. Obstet Gynecol. 2015; 126: 1012-1015.
  • Hamedani NS, Blümke F, Tolle F, Rohrbach F, Rühl H, Oldenburg J, Mayer G, Pötzsch B, Müller J. Capture and Release (CaR): a simplified procedure for one-tube isolation and concentration of single-stranded DNA during SELEX. Chem Commun (Camb). 2015; 51: 1135-1138.
  • Rühl H, Müller J, Wäschenbach J, Oldenburg J, Dewald O, Pötzsch B. Short-term venous stasis induces a fibrinolytic activation but not thrombin formation. J Atheroscler Thromb. 2014; 21: 1260-1270.
  • Al Chawa T, Ludwig KU, Fier H, Pötzsch B, Reich RH, Schmidt G, Braumann B, Daratsianos N, Böhmer AC, Schuencke H, Alblas M, Fricker N, Hoffmann P, Knapp M, Lange C, Nöthen MM, Mangold E. Nonsyndromic cleft lip with or without cleft palate: Increased burden of rare variants within Gremlin-1, a component of the bone morphogenetic protein 4 pathway. Birth Defects Res A Clin Mol Teratol. 2014; 100: 493-8.
  • Pavlova A, Delev D, Pezeshkpoor B, Müller J, Oldenburg J. Haemophilia A mutations in patients with non-severe phenotype associated with a discrepancy between one-stage and chromogenic factor VIII activity assays. Thromb Haemost. 2014; 111: 851-61.
  • Schlitter MC, Rühl H, Thiesler T, Penner AH, Berens C, Wolf D, Mayer K. Paraneoplastic disseminated intravascular coagulation caused by splenic littoral cell angioma. Ann Hematol. 2014; 93: 1795-1796.
  • Biswas A, Ivaskevicius V, Thomas A, Varvenne M, Brand B, Rott H, Haussels I, Ruehl H, Scholz U, Klamroth R, Oldenburg J. Eight novel F13A1 gene missense mutations in patients with mild FXIII deficiency: in silico analysis suggests changes in FXIII-A subunit structure/function. Ann Hematol. 2014; 93: 1665-1676.
  • Ludwig KU, Böhmer AC, Rubini M, Mossey PA, Herms S, Nowak S, Reutter H, Alblas MA, Lippke B, Barth S, Paredes-Zenteno M, Muñoz-Jimenez SG, Ortiz-Lopez R, Kreusch T, Hemprich A, Martini M, Braumann B, Jäger A, Pötzsch B, Molloy A, Peterlin B, Hoffmann P, Nöthen MM, Rojas-Martinez A, Knapp M, Steegers-Theunissen RP, Mangold E. Strong association of variants around FOXE1 and orofacial clefting. J Dent Res. 2014; 93: 376-81.
  • Schindewolf M, Steindl J, Beyer-Westendorf J, Schellong S, Dohmen PM, Brachmann J, Madlener K, Pötzsch B, Klamroth R, Hankowitz J, Banik N, Eberle S, Kropff S, Müller MM, Lindhoff-Last E. Frequent off-label use of fondaparinux in patients with suspected acute heparin-induced thrombocytopenia (HIT)--findings from the GerHIT multi-centre registry study. Thromb Res. 2014; 134: 29-35.
  • Rühl H, Schröder L, Müller J, Fimmers R, Sukhitashvili S, Welz J, Kuhn WC, Oldenburg J, Rudlowski C, Pötzsch B. Tamoxifen induces resistance to activated protein C. Thromb Res 2014; 133: 886-891.
  • Yassin AA, Elwaseef AM, Elnashar MM, Oldenburg J, Mayer G, Pötzsch B, Müller J. Protamine-adsorbed magnetic nanoparticles for efficient isolation and concentration of hepatitis-C virus from human plasma samples. Chem Commun (Camb). 2014; 50: 590-592.
  • Rühl H, Müller J, Harbrecht U, Fimmers R, Oldenburg J, Mayer G, Pötzsch B. Thrombin inhibition profiles in healthy individuals and thrombophilic patients. Thromb Haemost 2012; 107: 848-853.
  • Rühl H, Schröder L, Müller J, Sukhitashvili S, Welz J, Kuhn WC, Oldenburg J, Rudlowski C, Pötzsch B. Impact of hormone-associated resistance to activated protein C on the thrombotic potential of oral contraceptives: a prospective observational study. PLoS One. 2014; 9: e105007.
  • Rohrbach F, Schäfer F, Fichte MA, Pfeiffer F, Müller J, Pötzsch B, Heckel A, Mayer G. Aptamer-guided caging for selective masking of protein domains. Angew Chem Int Ed Engl. 2013; 52: 11912-5.
  • Hammerstingl C, Pötzsch B, Nickenig G. Resolution of giant left atrial appendage thrombus with rivaroxaban. Thromb Haemost. 2013; 109: 583-4.
  • Pahl S, Pavlova A, Driesen J, Müller J, Pötzsch B, Oldenburg J. In vitro characterization of recombinant factor VIII concentrates reveals significant differences in protein content, activity and thrombin activation profile. Haemophilia. 2013; 19: 392-8.
  • Nasser E, Mangold E, Tradowsky DC, Fier H, Becker J, Boehmer AC, Herberz R, Fricker N, Barth S, Wahle P, Nowak S, Reutter H, Reich RH, Lauster C, Braumann B, Kreusch T, Hemprich A, Pötzsch B, Hoffmann P, Kramer FJ, Knapp M, Lange C, Nöthen MM, Ludwig KU. Resequencing of VAX1 in patients with nonsyndromic cleft lip with or without cleft palate. Birth Defects Res A Clin Mol Teratol. 2012; 94: 925-33.
  • Rohrbach F, Fatthalla MI, Kupper T, Pötzsch B, Müller J, Petersen M, Pedersen EB, Mayer G. Chemical maturation of a bivalent aptamer by single domain variation. Chembiochem. 2012; 13: 631-4.
  • Rühl H, Müller J, Harbrecht U, Fimmers R, Oldenburg J, Mayer G, Pötzsch B. Thrombin inhibition profiles in healthy individuals and thrombophilic patients. Thromb Haemost. 2012; 107) :848-53.
  • Müller J, Friedrich M, Becher T, Braustein J, Kupper T, Berdel P, Gravius S, Rohrbach F, Oldenburg J, Mayer G, Pötzsch B. Monitoring of plasma levels of activated protein C using a clinically applicable oligonucleotide-based enzyme capture assay. J Thromb Haemost. 2012; 10: 390-398.
  • Westhofen P, Watzka M, Marinova M, Hass M, Kirfel G, Müller J, Bevans CG, Müller CR, Oldenburg J. Human vitamin K 2,3-epoxide reductase complex subunit 1-like 1 (VKORC1L1) mediates vitamin K-dependent intracellular antioxidant function. J Biol Chem. 2011; 286: 15085-94.
  • Müller J, Becher T, Braunstein J, Berdel P, Gravius S, Rohrbach F, Oldenburg J, Mayer G, Pötzsch B. Profiling of active thrombin in human blood by supramolecular complexes. Angew Chem Int Ed Engl. 2011; 50: 6075-6078.
  • Buff MC, Schäfer F, Wulffen B, Müller J, Pötzsch B, Heckel A, Mayer G. Dependence of aptamer activity on opposed terminal extensions: improvement of light-regulation efficiency. Nucleic Acids Res. 2010; 38: 2111-8.
  • Ehren K, Lamberti C, Poetzsch B, Majores M, Strach K, Sauerbruch T, Wasmuth JC. Massive hypercoagulable state despite full-dose anticoagulant treatment in a patient with occult malignancy: considerations concerning chemotherapy without definitive diagnosis. BMJ Case Rep. 2010; 2010: bcr0120091471.
  • Watzka M, Westhofen P, Hass M, Marinova M, Pötzsch B, Oldenburg J. Polymorphisms in VKORC1 and GGCX are not major genetic determinants of vitamin K-dependent coagulation factor activity in Western Germans. Thromb Haemost. 2009; 102: 418-20.
  • Birnbaum S, Ludwig KU, Reutter H, Herms S, de Assis NA, Diaz-Lacava A, Barth S, Lauster C, Schmidt G, Scheer M, Saffar M, Martini M, Reich RH, Schiefke F, Hemprich A, Pötzsch S, Pötzsch B, Wienker TF, Hoffmann P, Knapp M, Kramer FJ, Nöthen MM, Mangold E. IRF6 gene variants in Central European patients with non-syndromic cleft lip with or without cleft palate. Eur J Oral Sci. 2009; 117: 766-9.
  • Müller J, Isermann B, Dücker C, Salehi M, Meyer M, Friedrich M, Madhusudhan T, Oldenburg J, Mayer G, Pötzsch B. An exosite-specific ssDNA aptamer inhibits the anticoagulant functions of activated protein C and enhances inhibition by protein C inhibitor. Chem Biol. 2009; 16: 442-51.
  • Birnbaum S, Ludwig KU, Reutter H, Herms S, Steffens M, Rubini M, Baluardo C, Ferrian M, Almeida de Assis N, Alblas MA, Barth S, Freudenberg J, Lauster C, Schmidt G, Scheer M, Braumann B, Bergé SJ, Reich RH, Schiefke F, Hemprich A, Pötzsch S, Steegers-Theunissen RP, Pötzsch B, Moebus S, Horsthemke B, Kramer FJ, Wienker TF, Mossey PA, Propping P, Cichon S, Hoffmann P, Knapp M, Nöthen MM, Mangold E. Key susceptibility locus for nonsyndromic cleft lip with or without cleft palate on chromosome 8q24. Nat Genet. 2009; 41: 473-7.
  • Mayer G, Müller J, Mack T, Freitag DF, Höver T, Pötzsch B, Heckel A. Differential regulation of protein subdomain activity with caged bivalent ligands. Chembiochem. 2009; 10: 654-7.
  • Hammerstingl C, Omran H, Tripp C, Poetzsch B. How useful is determination of anti-factor Xa activity to guide bridging therapy with enoxaparin? A pilot study. Thromb Haemost. 2009; 101: 325-32.
  • Müller J, El-Maarri O, Oldenburg J, Pötzsch B, Mayer G. Monitoring the progression of the in vitro selection of nucleic acid aptamers by denaturing high-performance liquid chromatography. Anal Bioanal Chem. 2008; 390: 1033-7.
  • Müller J, Wulffen B, Pötzsch B, Mayer G. Multidomain targeting generates a high-affinity thrombin-inhibiting bivalent aptamer. Chembiochem. 2007; 8: 2223-6.
  • Stolz E, Oschmann P, Pötzsch B, Kraus J, Kaps M. Thrombocyte activation increases with the degree of carotid artery stenosis. J Stroke Cerebrovasc Dis. 2002; 11: 324-9.
  • Hernando JJ, Park TW, Fischer HP, Zivanovic O, Braun M, Pölcher M, Grünn U, Leutner C, Pötzsch B, Kuhn W. Vaccination with dendritic cells transfected with mRNA-encoded folate-receptor-alpha for relapsed metastatic ovarian cancer. Lancet Oncol. 2007; 8: 451-4.
  • Müller J, Eis-Hübinger AM, Däumer M, Kaiser R, Rox JM, Gürtler L, Hanfland P, Pötzsch B. A novel internally controlled real-time reverse transcription-PCR assay for HIV-1 RNA targeting the pol integrase genomic region. J Virol Methods. 2007; 142: 127-35.
  • Heckel A, Buff MC, Raddatz MS, Müller J, Pötzsch B, Mayer G. An anticoagulant with light-triggered antidote activity. Angew Chem Int Ed Engl. 2006; 45: 6748-50.
  • Ohlenforst S, Mueller J, Rox JM, Oldenburg J, Pötzsch B. Recurrent intracardiac thrombosis as an unusual manifestation of inherited thrombophilia. Int J Cardiol. 2007; 114: 380-1.
  • von der Brelie C, Kristof RA, Urbach H, Hartmann A, Hertfelder HJ, Poetzsch B. Ischemic brain damage triggers overt disseminated intravascular coagulation in a young woman with cerebral venous sinus thrombosis. Thromb Haemost. 2007; 98: 1371-3.
  • Riess FC, Poetzsch B, Madlener K, Cramer E, Doll KN, Doll S, Lorke DE, Kormann J, Mueller-Berghaus G. Recombinant hirudin for cardiopulmonary bypass anticoagulation: a randomized, prospective, and heparin-controlled pilot study. Thorac Cardiovasc Surg. 2007; 55: 233-8.
  • Watzka M, Nebel A, El Mokhtari NE, Ivandic B, Müller J, Schreiber S, Oldenburg J. Functional promoter polymorphism in the VKORC1 gene is no major genetic determinant for coronary heart disease in Northern Germans. Thromb Haemost. 2007; 97: M998-1002.
  • Rox JM, Müller J, Pötzsch B. Absence of fibrinogen alpha-, beta- and gamma-chain mRNA in human platelets. Br J Haematol. 2005; 130: 647-8.
  • Lang T, Bauters A, Braun SL, Pötzsch B, von Pape KW, Kolde HJ, Lakner M. Multi-centre investigation on reference ranges for ROTEM thromboelastometry. Blood Coagul Fibrinolysis. 2005; 16: 301-10.
  • Rox JM, Bugert P, Müller J, Schorr A, Hanfland P, Madlener K, Klüter H, Pötzsch B. Gene expression analysis in platelets from a single donor: evaluation of a PCR-based amplification technique. Clin Chem. 2004; 50: 2271-8.
  • Mueller J, Rox JM, Madlener K, Poetzsch B. Quantitative tissue factor gene expression analysis in whole blood: development and evaluation of a real-time PCR platform. Clin Chem. 2004; 50: 245-7.
  • Lütjens P, Siekmeier R, Hölzel V, Bedorf M, Hanfland P, Pötzsch B. Uptake of magnetic beads by dendritic cells, a major obstacle for the use of beads in biological assays. Acta Haematol. 2004; 112: 172-6.
  • Greinacher A, Eichler P, Albrecht D, Strobel U, Pötzsch B, Eriksson BI. Antihirudin antibodies following low-dose subcutaneous treatment with desirudin for thrombosis prophylaxis after hip-replacement surgery: incidence and clinical relevance. Blood. 2003; 101: 2617-9.
  • Skowasch D, Pötzsch B, Kuntz-Hehner S, Gampert T, Rox J, Omran H, Bauriedel G, Lüderitz B. Biventrikuläre Thrombenauflösung und Antikörper-Bildung unter Lepirudin-Therapie [Biventricular thrombi dissolution and antibody development with lepirudin therapy]. Dtsch Med Wochenschr. 2003; 128: 1531-4.
  • Appel TR, Pötzsch B, Müller J, von Lindern JJ, Bergé SJ, Reich RH. Comparison of three different preparations of platelet concentrates for growth factor enrichment. Clin Oral Implants Res. 2002; 13: 522-8.
  • Neuhaus T, Pötzsch B, Ko Y, Köhler G, Brackmann HH, Vetter H. Rezidivierende Spontanblutungen bei einer Patientin mit Leichtketten-Immunozytom [Recurrent spontaneous hemorrhage in a patient with light chain immunocytoma]. Praxis (Bern 1994). 2002; 91: 112-8.
  • Wilmer M, Rudin K, Kolde H, Poetzsch B, Lenz W, Moessmer G, Meili E, Egbring R, Gempeler-Messina P, Gempeler M, Bastian S, Kohler H. Evaluation of a sensitive colorimetric FXIII incorporation assay. Effects of FXIII Val34Leu, plasma fibrinogen concentration and congenital FXIII deficiency. Thromb Res. 2001; 102: 81-91.
  • Paus S, Pötzsch B, Risse JH, Klockgether T, Wüllner U. Chorea and antiphospholipid antibodies: treatment with methotrexate. Neurology. 2001; 56: 137-8.
  • Pötzsch B, Klövekorn WP, Madlener K. Use of heparin during cardiopulmonary bypass in patients with a history of heparin-induced thrombocytopenia. N Engl J Med. 2000; 343: 515.
  • Happich D, Madlener K, Schwaab R, Hanfland P, Pötzsch B. Application of the TaqMan-PCR for genotyping of the prothrombin G20210A mutation and of the thermolabile methylenetetrahydrofolate reductase mutation. Thromb Haemost. 2000; 84: 144-5.
  • Best Abstract, 68. Jahrestagung der GTH 2024 (N. Schwarz)
  • Reinhold-Eckstein-Investigator-Award der DGTI 2023 (N. Schwarz)
  • Best Abstract, 51. Jahrestagung der DGTI 2018 (H. Rühl)
  • Best Abstract, 50. Jahrestagung der DGTI 2017 (H. Rühl)
  • Hochschulwettbewerb „Zukunft Erfinden NRW“ 2015 (J. Müller, B. Pötzsch)
  • CSL Behring – Prof. Heimburger Award 2013 (H. Rühl)
  • Best Abstract, 55. Jahrestagung der GTH 2011 (H. Rühl)
  • Fritz-Schiff-Preis der DGTI 2010 (J. Müller)

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