Vitamin K-cycle - Dr. rer. nat. Katrin Czogalla-Nitsche, PhD
The role of vitamin K beyond coagulation
Vitamin K is essential to drive a post-translational modification, called γ-carboxylation, of 15 different vitamin K dependent proteins including several clotting factors but also non-haemostatic proteins such as GRP, MGP, Osteocalcin, PRGP1 and 2, TMG3 and 4 and Gas6. These vitamin K dependent non-haemostatic proteins have function in calcification, cell-signalling and other not yet identified pathways.
Our Emmy Noether research group study the function of the vitamin K cycle beyond blood coagulation and the interplay of the enzymes VKORC1, VKORC1-like1, and GGCX with vitamin K dependent proteins in cellular and mice models under heathy and disease conditions.
Dr. rer. nat. Katrin Czogalla-Nitsche, PhD
Emmy-Noether group leader / Principle investigator
Room: 2G/302
Phone: +49 (0)228-287 16783
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Prof. Dr. med. Johannes Oldenburg
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Suvoshree Ghosh
PhD student
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Francesco Forin
PhD student
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Anna-Lena Buhl
PhD student
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Katrin Kraus
Technician (BTA)
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Heike Höfer
Technican (BTA)
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Czogalla KJ, Liphardt K, Höning K, Hornung V, Biswas A, Watzka M, Oldenburg J.; VKORC1 and VKORC1L1 have distinctly different oral anticoagulant dose-response characteristics and binding sites.; Blood Adv. 2018 Mar;27;2(6):691-702.
Czogalla KJ, Biswas A, Höning K, Hornung V, Liphardt K, Watzka M, Oldenburg J.; Warfarin and vitamin K compete for binding to Phe55 in human VKOR.; Nat Struct Mol Biol. 2017 Jan;24(1):77-85.
Czogalla KJ, Biswas A, Rost S, Watzka M, Oldenburg J.; The Arg98Trp mutation in human VKORC1 causing VKCFD2 disrupts a di-Arginine-based ER retention motif.; Blood. 2014 Aug 21;124(8):1354-62
Czogalla KJ, Biswas A, Wendeln AC, Westhofen P, Müller CR, Watzka M, Oldenburg J.; Human VKORC1 mutations cause variable degrees of 4-hydroxycoumarin resistance and affect putative warfarin binding interfaces.; Blood. 2013 Oct 10;122(15):2743-50.
Stand: 04. September 2020
Stand: 04. September 2020
