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Aktuelle Publikationen vom IKCKP

High maternal BMI and low maternal blood BDNF may determine the limit of detection of amniotic fluid BDNF throughout gestation: Analysis of mother-fetus trios and literature review. Flöck A, Odainic A, Dolscheid-Pommerich R, Jaskolski MR, Diedrich AK, Puth MT, Schmidt S, Stoffel-Wagner B, Strizek B, Gembruch U, Merz WM PLoS One. 2022 Mar 10;17(3):e0265186. doi: 10.1371/journal.pone.0265186.

RIG-I-induced innate antiviral immunity protects mice from lethal SARS-CoV-2 infection. Marx S, Kümmerer BM, Grützner C, Kato H, Schlee M, Renn M, Bartok E, Hartmann G Mol Ther Nucleic Acids. 2022 Mar 8;27:1225-1234. doi: 10.1016/j.omtn.2022.02.008. Epub 2022 Feb 13.

Non-Cholesterol Sterols in Breast Milk and Risk of Allergic Outcomes in the First Two Years of Life. van Brakel L, Thijs C, Mensink RP, Lütjohann D, Plat J Nutrients. 2022 Feb 11;14(4):766. doi: 10.3390/nu14040766. 

Tetracycline ameliorates silica-induced pulmonary inflammation and fibrosis via inhibition of caspase-1. Peukert K, Steinhagen F, Fox M, Feuerborn C, Schulz S, Seeliger B, Schuss P, Schneider M, Frede S, Sauer A, Putensen C, Latz E, Wilhelm C, Bode C Respir Res. 2022 Feb 7;23(1):21. doi: 10.1186/s12931-022-01937-7.

Common variant p.D19H of the hepatobiliary sterol transporter ABCG8 increases the risk of gallstones in children. Krawczyk M, Niewiadomska O, Jankowska I, Jankowski K, Więckowski S, Lebensztejn D, Więcek S, Gozdowska J, Kułaga Z, Weber SN, Lütjohann D, Lammert F, Socha P Liver Int. 2022 Feb 7. doi: 10.1111/liv.15186.

Analyzing IMPROVE-IT Beyond LDL Cholesterol. Makhmudova U, Lütjohann D, Schulze PC, Davis HR, Weingärtner O J Am Coll Cardiol. 2022 Feb 1;79(4):e151-e152. doi: 10.1016/j.jacc.2021.10.047.

Recessive NLRC4-Autoinflammatory Disease Reveals an Ulcerative Colitis Locus. Steiner A, Reygaerts T, Pontillo A, Ceccherini I, Moecking J, Moghaddas F, Davidson S, Caroli F, Grossi A, Castro FFM, Kalil J, Gohr FN, Schmidt FI, Bartok E, Zillinger T, Hartmann G, Geyer M, Gattorno M, Mendonça LO, Masters SL J Clin Immunol. 2022 Feb;42(2):325-335. doi: 10.1007/s10875-021-01175-4. Epub 2021 Nov 16.

Plasma oxyphytosterols most likely originate from hepatic oxidation and subsequent spill-over in the circulation. Baumgartner S, Lütjohann D, Husche C, Kerksiek A, Groen AK, Mensink RP, Plat J J Steroid Biochem Mol Biol. 2022 Feb;216:106039. doi: 10.1016/j.jsbmb.2021.106039.

Autoantibodies to dense-fine-speckled 70 (DFS70) do not necessarily rule out connective tissue diseases. Mockenhaupt LM, Dolscheid-Pommerich R, Stoffel-Wagner B, Behning C, Brossart P, Schäfer VS Semin Arthritis Rheum. 2022 Feb;52:151936. doi: 10.1016/j.semarthrit.2021.12.006.

First genome-wide association study of esophageal atresia identifies three genetic risk loci at CTNNA3, FOXF1/FOXC2/FOXL1, and HNF1B. Gehlen J, Giel AS, Köllges R, Haas SL, Zhang R, Trcka J, Sungur AÖ, Renziehausen F, Bornholdt D, Jung D, Hoyer PD, Nordenskjöld A, Tibboel D, Vlot J, Spaander MCW, Smigiel R, Patkowski D, Roeleveld N, van Rooij IA, de Blaauw I, Hölscher A, Pauly M, Leutner A, Fuchs J, Niethammer J, Melissari MT, Jenetzky E, Zwink N, Thiele H, Hilger AC, Hess T, Trautmann J, Marks M, Baumgarten M, Bläss G, Landén M, Fundin B, Bulik CM, Pennimpede T, Ludwig M, Ludwig KU, Mangold E, Heilmann-Heimbach S, Moebus S, Herrmann BG, Alsabeah K, Burgos CM, Lilja HE, Azodi S, Stenström P, Arnbjörnsson E, Frybova B, Lebensztejn DM, Debek W, Kolodziejczyk E, Kozera K, Kierkus J, Kaliciński P, Stefanowicz M, Socha-Banasiak A, Kolejwa M, Piaseczna-Piotrowska A, Czkwianianc E, Nöthen MM, Grote P, Rygl M, Reinshagen K, Spychalski N, Ludwikowski B, Hubertus J, Heydweiller A, Ure B, Muensterer OJ, Aubert O, Gosemann JH, Lacher M, Degenhardt P, Boemers TM, Mokrowiecka A, Małecka-Panas E, Wöhr M, Knapp M, Seitz G, de Klein A, Oracz G, Brosens E, Reutter H, Schumacher J HGG Adv. 2022 Jan 25;3(2):100093. doi: 10.1016/j.xhgg.2022.100093. eCollection 2022 Apr 14.

Correlation between a quantitative anti-SARS-CoV-2 IgG ELISA and neutralization activity. Dolscheid-Pommerich R, Bartok E, Renn M, Kümmerer BM, Schulte B, Schmithausen RM, Stoffel-Wagner B, Streeck H, Saschenbrecker S, Steinhagen K, Hartmann G J Med Virol. 2022 Jan;94(1):388-392. doi: 10.1002/jmv.27287.

Plant Sterol-Poor Diet Is Associated with Pro-Inflammatory Lipid Mediators in the Murine Brain. Reinicke M, Leyh J, Zimmermann S, Chey S, Brkovic IB, Wassermann C, Landmann J, Lütjohann D, Isermann B, Bechmann I, Ceglarek U Int J Mol Sci. 2021 Dec 8;22(24):13207. doi: 10.3390/ijms222413207.

Carboplatin Dosing in Children Using Estimated Glomerular Filtration Rate: Equation Matters. van de Velde ME, den Bakker E, Blufpand HN, Kaspers GL, Abbink FCH, Kors AWA, Wilhelm AJ, Honeywell RJ, Peters GJ, Stoffel-Wagner B, Buffart LM, Bökenkamp A Cancers (Basel). 2021 Nov 26;13(23):5963. doi: 10.3390/cancers13235963.

Interferon-driven brain phenotype in a mouse model of RNaseT2 deficient leukoencephalopathy. Kettwig M, Ternka K, Wendland K, Krüger DM, Zampar S, Schob C, Franz J, Aich A, Winkler A, Sakib MS, Kaurani L, Epple R, Werner HB, Hakroush S, Kitz J, Prinz M, Bartok E, Hartmann G, Schröder S, Rehling P, Henneke M, Boretius S, Alia A, Wirths O, Fischer A, Stadelmann C, Nessler S, Gärtner J Nat Commun. 2021 Nov 11;12(1):6530. doi: 10.1038/s41467-021-26880-x.

 

APOE ɛ4 Is Associated with Postprandial Inflammation in Older Adults with Metabolic Syndrome Traits. Schönknecht YB, Crommen S, Stoffel-Wagner B, Coenen M, Fimmers R, Stehle P, Ramirez A, Egert S Nutrients. 2021 Nov 2;13(11):3924. doi: 10.3390/nu13113924.

Loneliness and the Social Brain: How Perceived Social Isolation Impairs Human Interactions. Lieberz J, Shamay-Tsoory SG, Saporta N, Esser T, Kuskova E, Stoffel-Wagner B, Hurlemann R, Scheele D Adv Sci (Weinh). 2021 Nov;8(21):e2102076. doi: 10.1002/advs.202102076.

Mouse Liver Compensates Loss of Sgpl1 by Secretion of Sphingolipids into Blood and Bile. Spohner AK, Jakobi K, Trautmann S, Thomas D, Schumacher F, Kleuser B, Lütjohann D, El-Hindi K, Grösch S, Pfeilschifter J, Saba JD, Meyer Zu Heringdorf D Int J Mol Sci. 2021 Sep 30;22(19):10617. doi: 10.3390/ijms221910617.

MAPK-pathway inhibition mediates inflammatory reprogramming and sensitizes tumors to targeted activation of innate immunity sensor RIG-I. Brägelmann J, Lorenz C, Borchmann S, Nishii K, Wegner J, Meder L, Ostendorp J, Ast DF, Heimsoeth A, Nakasuka T, Hirabae A, Okawa S, Dammert MA, Plenker D, Klein S, Lohneis P, Gu J, Godfrey LK, Forster J, Trajkovic-Arsic M, Zillinger T, Haarmann M, Quaas A, Lennartz S, Schmiel M, D'Rozario J, Thomas ES, Li H, Schmitt CA, George J, Thomas RK, von Karstedt S, Hartmann G, Büttner R, Ullrich RT, Siveke JT, Ohashi K, Schlee M, Sos ML Nat Commun. 2021 Sep 17;12(1):5505. doi: 10.1038/s41467-021-25728-8.

ADAR1 edits the SenZ and SenZ-ability of RNA. Zillinger T, Bartok E Immunity. 2021 Sep 14;54(9):1909-1911. doi: 10.1016/j.immuni.2021.08.021.

Fortifying a meal with oyster mushroom powder beneficially affects postprandial glucagon-like peptide-1, non-esterified free fatty acids and hunger sensation in adults with impaired glucose tolerance: a double-blind randomized controlled crossover trial. Dicks L, Jakobs L, Sari M, Hambitzer R, Ludwig N, Simon MC, Stehle P, Stoffel-Wagner B, Helfrich HP, Ahlborn J, Rühl M, Hartmann B, Holst JJ, Ellinger S Eur J Nutr. 2021 Sep 10. doi: 10.1007/s00394-021-02674-1.

Comparison of Perioperative High-Sensitive Troponin T and Troponin I Assays in Cardiac Surgery. Masseli F, Masseli M, Dolscheid-Pommerich R, Stoffel-Wagner B, Schiller W Heart Lung Circ. 2021 Sep 9:S1443-9506(21)01199-9. doi: 10.1016/j.hlc.2021.08.006.

Phytosterols and Cardiovascular Disease. Makhmudova U, Schulze PC, Lütjohann D, Weingärtner O Curr Atheroscler Rep. 2021 Sep 1;23(11):68. doi: 10.1007/s11883-021-00964-x.

24(R, S)-Saringosterol - From artefact to a biological medical agent. Vanbrabant K, Van Meel D, Kerksiek A, Friedrichs S, Dubbeldam M, Schepers M, Zhan N, Gutbrod K, Dörmann P, Liu HB, Mulder MT, Vanmierlo T, Lütjohann D J Steroid Biochem Mol Biol. 2021 Sep;212:105942. doi: 10.1016/j.jsbmb.2021.105942.

US-guided high-intensity focused ultrasound (HIFU) of abdominal tumors: outcome, early ablation-related laboratory changes and inflammatory reaction. A single-center experience from Germany. Tonguc T, Strunk H, Gonzalez-Carmona MA, Recker F, Lütjohann D, Thudium M, Conrad R, Becher MU, Savchenko O, Davidova D, Luechters G, Mustea A, Strassburg CP, Attenberger U, Pieper CC, Jenne J, Marinova M Int J Hyperthermia. 2021 Sep;38(2):65-74. doi: 10.1080/02656736.2021.1900926.

Sex differences in economic decision-making: Exogenous estradiol has opposing effects on fairness framing in women and men. Coenjaerts M, Pape F, Santoso V, Grau F, Stoffel-Wagner B, Philipsen A, Schultz J, Hurlemann R, Scheele D Eur Neuropsychopharmacol. 2021 Sept;50:46-54. doi: 10.1016/j.euroneuro.2021.04.006.

Extracellular Vesicle Separation Techniques Impact Results from Human Blood Samples: Considerations for Diagnostic Applications. Tzaridis T, Bachurski D, Liu S, Surmann K, Babatz F, Gesell Salazar M, Völker U, Hallek M, Herrlinger U, Vorberg I, Coch C, Reiners KS, Hartmann G Int J Mol Sci. 2021 Aug 26;22(17):9211. doi: 10.3390/ijms22179211.

Pro-Inflammatory Implications of 2-Hydroxypropyl-β-cyclodextrin Treatment. Houben T, Yadati T, de Kruijf R, Gijbels MJJ, Luiken JJFP, van Zandvoort M, Kapsokalyvas D, Lütjohann D, Westerterp M, Plat J, Leake D, Shiri-Sverdlov R Front Immunol. 2021 Aug 20;12:716357. doi: 10.3389/fimmu.2021.716357.

Extrahepatic Surgery in Cirrhosis Significantly Increases Portal Pressure in Preclinical Animal Models. Chang J, Meinke J, Geck M, Hebest M, Böhling N, Dolscheid-Pommerich R, Stoffel-Wagner B, Kristiansen G, Overhaus M, Peyman LO, Klein S, Uschner FE, Brol MJ, Vilz TO, Lingohr P, Kalff JC, Jansen C, Strassburg CP, Wehner S, Trebicka J, Praktiknjo M Front Physiol. 2021 Aug 20;12:720898. doi: 10.3389/fphys.2021.720898.

Malaria parasites both repress host CXCL10 and use it as a cue for growth acceleration. Ofir-Birin Y, Ben Ami Pilo H, Cruz Camacho A, Rudik A, Rivkin A, Revach OY, Nir N, Block Tamin T, Abou Karam P, Kiper E, Peleg Y, Nevo R, Solomon A, Havkin-Solomon T, Rojas A, Rotkopf R, Porat Z, Avni D, Schwartz E, Zillinger T, Hartmann G, Di Pizio A, Quashie NB, Dikstein R, Gerlic M, Torrecilhas AC, Levy C, Nolte-'t Hoen ENM, Bowie AG, Regev-Rudzki N Nat Commun. 2021 Aug 11;12(1):4851. doi: 10.1038/s41467-021-24997-7.

PPAR-Responsive Elements Enriched with Alu Repeats May Contribute to Distinctive PPARγ-DNMT1 Interactions in the Genome. Sharma A, Tobar-Tosse F, Chand Dakal T, Liu H, Biswas A, Menon A, Paruchuri A, Katsonis P, Lichtarge O, Gromiha MM, Ludwig M, Schmidt-Wolf IGH, Holz FG, Loeffler KU, Herwig-Carl MC Cancers (Basel). 2021 Aug 7;13(16):3993. doi: 10.3390/cancers13163993.

Markers of cholesterol synthesis to cholesterol absorption across the spectrum of non-dialysis CKD: An observational study. Emrich IE, Heine GH, Schulze PC, Rogacev KS, Fliser D, Wagenpfeil S, Böhm M, Lütjohann D, Weingärtner O Pharmacol Res Perspect. 2021 Aug;9(4):e00801. doi: 10.1002/prp2.801.

Monocyte-dependent co-stimulation of cytokine induction in human γδ T cells by TLR8 RNA ligands. Serrano R, Coch C, Peters C, Hartmann G, Wesch D, Kabelitz D Sci Rep. 2021 Jul 27;11(1):15231. doi: 10.1038/s41598-021-94428-6.

Fibroblast Growth Factor 21 Response in a Preclinical Alcohol Model of Acute-on-Chronic Liver Injury. Christidis G, Karatayli E, Hall RA, Weber SN, Reichert MC, Hohl M, Qiao S, Boehm U, Lütjohann D, Lammert F, Karatayli SC Int J Mol Sci. 2021 Jul 23;22(15):7898. doi: 10.3390/ijms22157898.

An epigenetic GPI anchor defect impairs TLR4 signaling in the B cell transdifferentiation model for primary human monocytes BLaER1. Wegner J, Zillinger T, Schlee-Guimaraes TM, Bartok E, Schlee M. Sci Rep. 2021 Jul 22;11(1):14983. doi: 10.1038/s41598-021-94386-z.

Inhibition of Extracellular Cathepsin D Reduces Hepatic Lipid Accumulation and Leads to Mild Changes in Inflammationin NASH Mice. Yadati T, Houben T, Bitorina A, Oligschlaeger Y, Gijbels MJ, Mohren R, Lütjohann D, Khurana P, Goyal S, Kulkarni A, Theys J, Cillero-Pastor B, Shiri-Sverdlov R Front Immunol. 2021 Jul 16;12:675535. doi: 10.3389/fimmu.2021.675535.

DPP9 holds all the CARD8s for inflammasome regulation. Wegner J, Kirchhoff A, Schlee M Immunity. 2021 Jul 13;54(7):1363-1365. doi: 10.1016/j.immuni.2021.06.005.

Intercellular cGAMP transmission induces innate immune activation and tissue inflammation in Trex1 deficiency. Jütte BB, Krollmann C, Cieslak K, Koerber RM, Boor P, Graef CM, Bartok E, Wagner M, Carell T, Landsberg J, Aymans P, Wenzel J, Brossart P, Teichmann LL iScience. 2021 Jul 9;24(8):102833. doi: 10.1016/j.isci.2021.102833.

The many faces of cGAS: how cGAS activation is controlled in the cytosol, the nucleus, and during mitosis. Herzner AM, Schlee M, Bartok E Signal Transduct Target Ther. 2021 Jul 9;6(1):260. doi: 10.1038/s41392-021-00684-3.

Inhibition of Caspase-1 with Tetracycline Ameliorates Acute Lung Injury. Peukert K, Fox M, Schulz S, Feuerborn C, Frede S, Putensen C, Wrigge H, Kümmerer BM, David S, Seeliger B, Welte T, Latz E, Klinman D, Wilhelm C, Steinhagen F, Bode C Am J Respir Crit Care Med. 2021 Jul 1;204(1):53-63. doi: 10.1164/rccm.202005-1916OC.

LAMP-Seq enables sensitive, multiplexed COVID-19 diagnostics using molecular barcoding. Ludwig KU, Schmithausen RM, Li D, Jacobs ML, Hollstein R, Blumenstock K, Liebing J, Słabicki M, Ben-Shmuel A, Israeli O, Weiss S, Ebert TS, Paran N, Rüdiger W, Wilbring G, Feldman D, Lippke B, Ishorst N, Hochfeld LM, Beins EC, Kaltheuner IH, Schmitz M, Wöhler A, Döhla M, Sib E, Jentzsch M, Borrajo JD, Strecker J, Reinhardt J, Cleary B, Geyer M, Hölzel M, Macrae R, Nöthen MM, Hoffmann P, Exner M, Regev A, Zhang F, Schmid-Burgk JL Nat Biotechnol. 2021 Jun 29. doi: 10.1038/s41587-021-00966-9.

Memory B cells targeting SARS-CoV-2 spike protein and their dependence on CD4+ T cell help. Pušnik J, Richter E, Schulte B, Dolscheid-Pommerich R, Bode C, Putensen C, Hartmann G, Alter G, Streeck H Cell Rep. 2021 Jun 29;35(13):109320. doi: 10.1016/j.celrep.2021.109320.

Animal models of SARS-CoV-2 and COVID-19 for the development of prophylactic and therapeutic interventions. Renn M, Bartok E, Zillinger T, Hartmann G, Behrendt R Pharmacol Ther. 2021 Jun 23;228:107931. doi: 10.1016/j.pharmthera.2021.107931.

Lactate dehydrogenase B regulates macrophage metabolism in the tumor microenvironment. Frank AC, Raue R, Fuhrmann DC, Sirait-Fischer E, Reuse C, Weigert A, Lütjohann D, Hiller K, Syed SN, Brüne B Theranostics. 2021 Jun 4;11(15):7570-7588. doi: 10.7150/thno.58380.

Human IFITM3 restricts chikungunya virus and Mayaro virus infection and is susceptible to virus-mediated counteraction. Franz S, Pott F, Zillinger T, Schüler C, Dapa S, Fischer C, Passos V, Stenzel S, Chen F, Döhner K, Hartmann G, Sodeik B, Pessler F, Simmons G, Drexler JF, Goffinet C Life Sci Alliance. 2021 Jun 2;4(7):e202000909. doi: 10.26508/lsa.202000909.

Antihormone treatment differentially regulates PSA secretion, PSMA expression and 68Ga-PSMA uptake in LNCaP cells. Mathy CS, Mayr T, Kürpig S, Meisenheimer M, Dolscheid-Pommerich RC, Stoffel-Wagner B, Kristiansen G, Essler M, Muders MH, Bundschuh RA J Cancer Res Clin Oncol. 2021 Jun;147(6):1733-1743. doi: 10.1007/s00432-021-03583-w.

Dynamics of the enterohepatic circulation of bile acids in healthy humans. Stellaard F, Lütjohann D Am J Physiol Gastrointest Liver Physiol. 2021 May 12. doi: 10.1152/ajpgi.00476.2020.

Anti-Inflammatory Effects of Dietary Plant Stanol Supplementation Are Largely Dependent on the Intake of Cholesterol in a Mouse Model of Metabolic Inflammation. Magro Dos Reis I, Houben T, Gijbels MJJ, Lütjohann D, Plat J, Shiri-Sverdlov R Biomedicines. 2021 May 6;9(5):518. doi: 10.3390/biomedicines9050518.

Detectable SARS-CoV-2 RNAemia in Critically Ill Patients, but Not in Mild and Asymptomatic Infections. Richter E, Al Arashi D, Schulte B, Bode C, Marx B, Aldabbagh S, Schlüter C, Kümmerer BM, Oldenburg J, Funk MB, Putensen C, Schmithausen RM, Hartmann G, Eis-Hübinger A, Streeck H Transfus Med Hemother. 2021 May;48(3):154-160. doi: 10.1159/000515841.

Enemy or ally? Fasting as an essential regulator of immune responses. Wilhelm C, Surendar J, Karagiannis F Trends Immunol. 2021 May;42(5):389-400. doi: 10.1016/j.it.2021.03.007.

Atxn2-CAG100-KnockIn mouse spinal cord shows progressive TDP43 pathology associated with cholesterol biosynthesis suppression. Canet-Pons J, Sen NE, Arsović A, Almaguer-Mederos LE, Halbach MV, Key J, Döring C, Kerksiek A, Picchiarelli G, Cassel R, René F, Dieterlé S, Fuchs NV, König R, Dupuis L, Lütjohann D, Gispert S, Auburger G Neurobiol Dis. 2021 May;152:105289. doi: 10.1016/j.nbd.2021.105289.

Serum 4β-hydroxycholesterol increases during fluconazole treatment. Lütjohann D, Stellaard F, Kerksiek A, Lötsch J, Oertel BG Eur J Clin Pharmacol. 2021 May;77(5):659-669. doi: 10.1007/s00228-020-03041-5.

Metabolic profiling in serum, cerebrospinal fluid, and brain of patients with cerebrotendinous xanthomatosis. Höflinger P, Hauser S, Yutuc E, Hengel H, Griffiths L, Radelfahr F, Howell OW, Wang Y, Connor SL, Duell PB, DeBarber AE, Martus P, Lütjohann D, Griffiths WJ, Schöls L J Lipid Res. 2021 Apr 20;62:100078. doi: 10.1016/j.jlr.2021.100078.

Currarino syndrome: a comprehensive genetic review of a rare congenital disorder. Dworschak GC, Reutter HM, Ludwig M Orphanet J Rare Dis. 2021 Apr 9;16(1):167. doi: 10.1186/s13023-021-01799-0.

Efferocytosis potentiates the expression of arachidonate 15-lipoxygenase (ALOX15) in alternatively activated human macrophages through LXR activation. Snodgrass RG, Benatzy Y, Schmid T, Namgaladze D, Mainka M, Schebb NH, Lütjohann D, Brüne B Cell Death Differ. 2021 Apr;28(4):1301-1316. doi: 10.1038/s41418-020-00652-4.

Anti-PCSK 9 antibodies increase the ratios of the brain-specific oxysterol 24S-hydroxycholesterol to cholesterol and to 27-hydroxycholesterol in the serum. Lütjohann D, Stellaard F, Bölükbasi B, Kerksiek A, Parhofer KG, Laufs U Br J Clin Pharmacol. 2021 Mar 31. doi: 10.1111/bcp.14841.

24(S)-Saringosterol Prevents Cognitive Decline in a Mouse Model for Alzheimer's Disease. Martens N, Schepers M, Zhan N, Leijten F, Voortman G, Tiane A, Rombaut B, Poisquet J, Sande NV, Kerksiek A, Kuipers F, Jonker JW, Liu H, Lütjohann D, Vanmierlo T, Mulder MT Mar Drugs. 2021 Mar 27;19(4):190. doi: 10.3390/md19040190.

SP-D Serum Levels Reveal Distinct Epithelial Damage in Direct Human ARDS. Peukert K, Seeliger B, Fox M, Feuerborn C, Sauer A, Schuss P, Schneider M, David S, Welte T, Putensen C, Wilhelm C, Steinhagen F, Bode C J Clin Med. 2021 Feb 12;10(4):737. doi: 10.3390/jcm10040737.

Birthweight Differences in Adolescent Monozygotic Twins Influence Androgens, Psychological Morbidity, and Health-Related Quality of Life. Schmitz L, Schulte S, Stoffel-Wagner B, Bartmann P, Plamper M, Schreiner F, Woelfle J, Gohlke B Horm Res Paediatr. 2020;93(7-8):433-441. doi: 10.1159/000512653.

Diet-dependent regulation of TGFβ impairs reparative innate immune responses after demyelination. Bosch-Queralt M, Cantuti-Castelvetri L, Damkou A, Schifferer M, Schlepckow K, Alexopoulos I, Lütjohann D, Klose C, Vaculčiaková L, Masuda T, Prinz M, Monroe KM, Di Paolo G, Lewcock JW, Haass C, Simons M Nat Metab. 2021 Feb;3(2):211-227. doi: 10.1038/s42255-021-00341-7.

Structure-guided multivalent nanobodies block SARS-CoV-2 infection and suppress mutational escape. Koenig PA, Das H, Liu H, Kümmerer BM, Gohr FN, Jenster LM, Schiffelers LDJ, Tesfamariam YM, Uchima M, Wuerth JD, Gatterdam K, Ruetalo N, Christensen MH, Fandrey CI, Normann S, Tödtmann JMP, Pritzl S, Hanke L, Boos J, Yuan M, Zhu X, Schmid-Burgk JL, Kato H, Schindler M, Wilson IA, Geyer M, Ludwig KU, Hällberg BM, Wu NC, Schmidt FI Science. 2021 Jan 12:eabe6230. doi: 10.1126/science.abe6230.

Testosterone serum levels are not predictive of maternal virilization in hyperreactio luteinalis. Condic M, Merz WM, Gembruch U, Klingmüller D, Stoffel-Wagner B, Dolscheid-Pommerich R Arch Gynecol Obstet. 2021 Jan;303(1):129-134. doi: 10.1007/s00404-020-05745-6.

No effects of PCSK9-inhibitor treatment on spatial learning, locomotor activity, and novel object recognition in mice. Schlunk F, Fischer P, Princen HMG, Rex A, Prinz V, Foddis M, Lütjohann D, Laufs U, Endres M Behav Brain Res. 2021 Jan 1;396:112875. doi: 10.1016/j.bbr.2020.112875.

Cholesterol metabolites and plant sterols in cerebrospinal fluid are associated with Alzheimer´s cerebral pathology and clinical disease progression. Jahn T, Clark C, Kerksiek A, Lewczuk P, Lütjohann D, Popp J J Steroid Biochem Mol Biol. 2021 Jan;205:105785. doi: 10.1016/j.jsbmb.2020.105785.

U-DCS: characterization of the first permanent human dendritic sarcoma cell line. Mellert K, Benckendorff J, Leithäuser F, Zimmermann K, Wiegand P, Frascaroli G, Buck M, Malaise M, Hartmann G, Barchet W, Fürst D, Mytilineos J, Mayer-Steinacker R, Viardot A, Möller P Sci Rep. 2020 Dec 4;10:21221. doi: 10.1038/s41598-020-77471-7.

Infection fatality rate of SARS-CoV2 in a super-spreading event in Germany. Streeck H, Schulte B, Kümmerer BM, Richter E, Höller T, Fuhrmann C, Bartok E, Dolscheid-Pommerich R, Berger M, Wessendorf L, Eschbach-Bludau M, Kellings A, Schwaiger A, Coenen M, Hoffmann P, Stoffel-Wagner B, Nöthen MM, Eis-Hübinger AM, Exner M, Schmithausen RM, Schmid M, Hartmann G Nat. Commun. 2020 Nov 17;11:5829. doi: 10.1038/s41467-020-19509-y.

Serum 4β-hydroxycholesterol increases during fluconazole treatment. Lütjohann D, Stellaard F, Kerksiek A, Lötsch J, Oertel BG Eur J Clin Pharmacol. 2020 Nov 17. doi: 10.1007/s00228-020-03041-5.

Efferocytosis potentiates the expression of arachidonate 15-lipoxygenase (ALOX15) in alternatively activated human macrophages through LXR activation. Snodgrass RG, Benatzy Y, Schmid T, Namgaladze D, Mainka M, Schebb NH, Lütjohann D, Brüne B Cell Death Differ. 2020 Nov 11. doi: 10.1038/s41418-020-00652-4.

Cholesterol metabolites and plant sterols in cerebrospinal fluid are associated with Alzheimer´s cerebral pathology and clinical disease progression. Jahn T, Clark C, Kerksiek A, Lewczuk P, Lütjohann D, Popp J J Steroid Biochem Mol Biol. 2020 Nov 7:105785. doi: 10.1016/j.jsbmb.2020.105785.

Effect of DL-Methionine Supplementation on Tissue and Plasma Antioxidant Status and Concentrations of Oxidation Products of Cholesterol and Phytosterols in Heat-Processed Thigh Muscle of Broilers. Zeitz JO, Ehbrecht T, Fleischmann A, Most E, Gessner DK, Friedrichs S, Sparenberg M, Failing K, Whelan R, Lütjohann D, Eder K Animals (Basel). 2020 Nov 5;10(11):E2050. doi: 10.3390/ani10112050.

Effects of Inhibition or Deletion of PCSK9 (Proprotein Convertase Subtilisin/Kexin Type 9) on Intracerebral Hemorrhage Volumes in Mice. Schlunk F, Fischer P, Princen HMG, Rex A, Prinz V, Foddis M, Lütjohann D, Laufs U, Endres M Stroke. 2020 Nov;51(11):e297-e298. doi: 10.1161/STROKEAHA.120.030087.

Impact of a Gap Junction Protein Alpha 4 Variant on Clinical Disease Phenotype in F508del Homozygous Patients With Cystic Fibrosis. Horn T, Ludwig M, Eickmeier O, Neerinex AH, Maitland-van der Zee AH, Smaczny C, Wagner TOF, Schubert R, Zielen S, Majoor C, Bos LD, Schmitt-Grohé S Front Genet. 2020 Oct 28;11:570403. doi: 10.3389/fgene.2020.570403.

Influence of Prenatal Environment on Androgen Steroid Metabolism In Monozygotic Twins With Birthweight Differences. Schulte S, Schreiner F, Plamper M, Kasner C, Gruenewald M, Bartmann P, Fimmers R, Hartmann MF, Wudy SA, Stoffel-Wagner B, Woelfle J, Gohlke B J Clin Endocrinol Metab. 2020 Oct 1;105(10):dgaa480. doi: 10.1210/clinem/dgaa480.

Analysis of Serum miRNA in Glioblastoma Patients: CD44-Based Enrichment of Extracellular Vesicles Enhances Specificity for the Prognostic Signature. Tzaridis T, Reiners KS, Weller J, Bachurski D, Schäfer N, Schaub C, Hallek M, Scheffler B, Glas M, Herrlinger U, Wild S, Coch C, Hartmann G Int. J. Mol. Sci. 2020 Sep 29;21(19):7211. doi: 10.3390/ijms21197211.

A continuous responder algorithm to optimize clinical management of small-cell lung cancer with progastrin-releasing peptide as a simple blood test. Muley T, Zhang X, Holdenrieder S, Korse CM, Zhi XY, Molina R, Liu Z, Hartmann G, van den Heuvel MM, Qian K, Marrades R, Engel C, He Y, Wehnl B, Dayyani F, Herth F Tumour Biol. 2020 Sep;42(9):1010428320958603. doi: 10.1177/1010428320958603.

The coffee ingredients caffeic acid and caffeic acid phenylethyl ester protect against irinotecan-induced leukopenia and oxidative stress response. Kalthoff S, Paulusch S, Rupp A, Holdenrieder S, Hartmann G, Strassburg CP Br J Pharmacol. 2020 Sep;177(18):4193-4208. doi: 10.1111/bph.15162.

Diverse enzymatic activities mediate antiviral immunity in prokaryotes. Gao L, Altae-Tran H, Böhning F, Makarova KS, Segel M, Schmid-Burgk JL, Koob J, Wolf YI, Koonin EV, Zhang F Science. 2020 Aug 28;369(6507):1077-1084. doi: 10.1126/science.aba0372.

Testosterone serum levels are not predictive of maternal virilization in hyperreactio luteinalis. Condic M, Merz WM, Gembruch U, Klingmüller D, Stoffel-Wagner B, Dolscheid-Pommerich R Arch Gynecol Obstet. 2020 Aug 19. doi: 10.1007/s00404-020-05745-6.

Hematologic changes after short term hypoxia in non-elite apnea divers under voluntary dry apnea conditions. Dolscheid-Pommerich RC, Stoffel-Wagner B, Alberts J, Fimmers R, Eichhorn L PLoS One. 2020 Aug 13;15(8):e0237673. doi: 10.1371/journal.pone.0237673.

Absence of cGAS-mediated type I IFN responses in HIV-1-infected T cells. Elsner C, Ponnurangam A, Kazmierski J, Zillinger T, Jansen J, Todt D, Döhner K, Xu S, Ducroux A, Kriedemann N, Malassa A, Larsen PK, Hartmann G, Barchet W, Steinmann E, Kalinke U, Sodeik B, Goffinet C Proc. Natl. Acad. U.S.A. 2020 Aug 11;117(32):19475-19486. doi: 10.1073/pnas.2002481117.

SLC20A1 Is Involved in Urinary Tract and Urorectal Development. Rieke JM, Zhang R, Braun D, Yilmaz Ö, Japp AS, Lopes FM, Pleschka M, Hilger AC, Schneider S, Newman WG, Beaman GM, Nordenskjöld A, Ebert AK, Promm M, Rösch WH, Stein R, Hirsch K, Schäfer FM, Schmiedeke E, Boemers TM, Lacher M, Kluth D, Gosemann JH, Anderberg M, Barker G, Holmdahl G, Läckgren G, Keene D, Cervellione RM, Giorgio E, Di Grazia M, Feitz WFJ, Marcelis CLM, Van Rooij IALM, Bökenkamp A, Beckers GMA, Keegan CE, Sharma A, Dakal TC, Wittler L, Grote P, Zwink N, Jenetzky E, Brusco A, Thiele H, Ludwig M, Schweizer U, Woolf AS, Odermatt B, Reutter H Front Cell Dev Biol. 2020 Aug 7;8:567. doi: 10.3389/fcell.2020.00567.

Targeting the innate immunoreceptor RIG-I overcomes melanoma-intrinsic resistance to T cell immunotherapy. Such L, Zhao F, Liu D, Thier B, Le-Trilling VTK, Sucker A, Coch C, Pieper N, Howe S, Bhat H, Kalkavan H, Ritter C, Brinkhaus R, Ugurel S, Köster J, Seifert U, Dittmer U, Schuler M, Lang KS, Kufer TA, Hartmann G, Becker JC, Horn S, Ferrone S, Liu D, Van Allen EM, Schadendorf D, Griewank K, Trilling M, Paschen A J Clin Invest. 2020 Aug 3;130(8):4266-4281. doi: 10.1172/JCI131572.

Sex-opposed inflammatory effects of 27-hydroxycholesterol are mediated via differences in estrogen signaling. Houben T, Bitorina AV, Oligschlaeger Y, Jeurissen ML, Rensen S, Köhler SE, Westerterp M, Lütjohann D, Theys J, Romano A, Plat J, Shiri-Sverdlov R J Pathol. 2020 Aug;251(4):429-439. doi: 10.1002/path.5477.

It's time to personalize and optimize lipid-lowering therapy. Weingärtner O, Patel SB, Lütjohann D Eur Heart J. 2020 Jul 21;41(28):2629-2631. doi: 10.1093/eurheartj/ehaa445.

Immune Sensing Mechanisms that Discriminate Self from Altered Self and Foreign Nucleic Acids. Bartok E, Hartmann G Immunity. 2020 Jul 14;53(1):54-77. doi: 10.1016/j.immuni.2020.06.014.

LAMP-Seq: Population-Scale COVID-19 Diagnostics Using Combinatorial Barcoding. Schmid-Burgk JL,  Schmithausen RM, Li D, Hollstein R, Ben-Shmuel A, Israeli O, Weiss S, Paran N, Wilbring G, Liebing J, Feldman D, Słabicki M, Lippke B, Sib E, Borrajo J, Strecker J, Reinhardt J, Hoffmann P, Cleary B, Hölzel M,  Nöthen MM, Exner M, Ludwig KU, Regev A, Zhang F bioRxiv. 2020 Jun 8. doi: 10.1101/2020.04.06.025635.

Human exome and mouse embryonic expression data implicate ZFHX3, TRPS1, and CHD7 in human esophageal atresia. Zhang R, Gehlen J, Kawalia A, Melissari MT, Dakal TC, Menon AM, Höfele J, Riedhammer K, Waffenschmidt L, Fabian J, Breuer K, Kalanithy J, Hilger AC, Sharma A, Hölscher A, Boemers TM, Pauly M, Leutner A, Fuchs J, Seitz G, Ludwikowski BM, Gomez B, Hubertus J, Heydweiller A, Kurz R, Leonhardt J, Kosch F, Holland-Cunz S, Münsterer O, Ure B, Schmiedeke E, Neser J, Degenhardt P, Märzheuser S, Kleine K, Schäfer M, Spychalski N, Deffaa OJ, Gosemann JH, Lacher M, Heilmann-Heimbach S, Zwink N, Jenetzky E, Ludwig M, Grote P, Schumacher J, Thiele H, Reutter H PLoS One. 2020 Jun 5;15(6):e0234246. doi: 10.1371/journal.pone.0234246.

Dietary plant stanol ester supplementation reduces peripheral symptoms in a mouse model of Niemann-Pick type C1 disease. Magro Dos Reis I, Houben T, Oligschläger Y, Bücken L, Steinbusch H, Cassiman D, Lütjohann D, Westerterp M, Prickaerts J, Plat J, Shiri-Sverdlov R J Lipid Res. 2020 Jun;61(6):830-839. doi: 10.1194/jlr.RA120000632.

Kinetics of oxytocin effects on amygdala and striatal reactivity vary between women and men. Lieberz J, Scheele D, Spengler FB, Matheisen T, Schneider L, Stoffel-Wagner B, Kinfe TM, Hurlemann R Neuropsychopharmacology. 2020 Jun;45(7):1134-1140. doi: 10.1038/s41386-019-0582-6.

Ubiquitin Carboxyl-Terminal Hydrolases (UCHs): Potential Mediators for Cancer and Neurodegeneration. Sharma A, Liu H, Tobar-Tosse F, Chand Dakal T, Ludwig M, Holz FG, Loeffler KU, Wüllner U, Herwig-Carl MC Int J Mol Sci. 2020 May 30;21(11):3910. doi: 10.3390/ijms21113910.

Microbiota-Induced Type I Interferons Instruct a Poised Basal State of Dendritic Cells. Schaupp L, Muth S, Rogell L, Kofoed-Branzk M, Melchior F, Lienenklaus S, Ganal-Vonarburg SC, Klein M, Guendel F, Hain T, Schütze K, Grundmann U, Schmitt V, Dorsch M, Spanier J, Larsen PK, Schwanz T, Jäckel S, Reinhardt C, Bopp T, Danckwardt S, Mahnke K, Heinz GA, Mashreghi MF, Durek P, Kalinke U, Kretz O, Huber TB, Weiss S, Wilhelm C, Macpherson AJ, Schild H, Diefenbach A, Probst HC Cell. 2020 May 28;181(5):1080-1096.e19. doi: 10.1016/j.cell.2020.04.022.

Highly Parallel Profiling of Cas9 Variant Specificity. Schmid-Burgk JL, Gao L, Li D, Gardner Z, Strecker J, Lash B, Zhang F Mol Cell. 2020 May 21;78(4):794-800.e8. doi: 10.1016/j.molcel.2020.02.023.

IGF-I in cord blood is predictive of final height in monozygotic twins with intra-twin birth weight differences. Kasner C, Schulte S, Schreiner F, Fimmers R, Stoffel-Wagner B, Bartmann P, Woelfle J, Gohlke B Clin Endocrinol (Oxf). 2020 May 13. doi: 10.1111/cen.14221.

Obstetric and Neonatal Outcome of Pregnancy in Carney Complex: A Case Report. Ralser DJ, Strizek B, Kupczyk P, Stoffel-Wagner B, Altengarten J, Müller A, Woelfle J, Gembruch U, Klingmueller D, Merz WM, Paschkowiak-Christes A Front Endocrinol. 2020 May 8;11:296. doi: 10.3389/fendo.2020.00296.

Acute Effects of Three Different Meal Patterns on Postprandial Metabolism in Older Individuals with a Risk Phenotype for Cardiometabolic Diseases: A Randomized Controlled Crossover Trial. Schönknecht YB, Crommen S, Stoffel-Wagner B, Coenen M, Fimmers R, Holst JJ, Simon MC, Stehle P, Egert S Mol Nutr Food Res. 2020 May;64(9):e1901035. doi: 10.1002/mnfr.201901035. 

Edible seaweed-derived constituents: an undisclosed source of neuroprotective compounds. Schepers M, Martens N, Tiane A, Vanbrabant K, Liu HB, Lütjohann D, Mulder M, Vanmierlo T Neural Regen Res. 2020 May;15(5):790-795. doi: 10.4103/1673-5374.268894.

Importance of γ-secretase in the regulation of liver X receptor and cellular lipid metabolism. Gutierrez E, Lütjohann D, Kerksiek A, Fabiano M, Oikawa N, Kuerschner L, Thiele C, Walter J Life Sci Alliance. 2020 Apr 30;3(6):e201900521. doi: 10.26508/lsa.201900521.

Immune Sensing of Synthetic, Bacterial, and Protozoan RNA by Toll-like Receptor 8 Requires Coordinated Processing by RNase T2 and RNase 2. Ostendorf T, Zillinger T, Andryka  K, Schlee-Guimaraes TM, Schmitz S, Marx S, Bayrak K, Linke R, Salgert S, Wegner J, Grasser T, Bauersachs S, Soltesz L, Hübner MP, Nastaly M, Coch C, Kettwig M, Roehl I, Henneke M, Hoerauf A, Barchet W, Gärtner J, Schlee M, Hartmann G, Bartok E Immunity. 2020 Apr 14;52(4):591-605.e6. doi: 10.1016/j.immuni.2020.03.009.

Lipid-Droplet Formation Drives Pathogenic Group 2 Innate Lymphoid Cells in Airway Inflammation. Karagiannis F, Masouleh SK, Wunderling K, Surendar J, Schmitt V, Kazakov A, Michla M, Hölzel M, Thiele C, Wilhelm C Immunity. 2020 Apr 14;52(4):620-634.e6. doi: 10.1016/j.immuni.2020.03.003.

High RIG-I expression in ovarian cancer associates with an immune-escape signature and poor clinical outcome. Wolf D, Fiegl H, Zeimet AG, Wieser V, Marth C, Sprung S, Sopper S, Hartmann G, Reimer D, Boesch M Int J Cancer. 2020 Apr 1;146(7):2007-2018. doi: 10.1002/ijc.32818.

HDL inhibits endoplasmic reticulum stress-induced apoptosis of pancreatic β-cells in vitro by activation of Smoothened. Yalcinkaya M, Kerksiek A, Gebert K, Annema W, Sibler R, Radosavljevic S, Lütjohann D, Rohrer L, von Eckardstein A J Lipid Res. 2020 Apr;61(4):492-504. doi: 10.1194/jlr.RA119000509.

High-Sensitivity Troponin T Testing: Consequences on Daily Clinical Practice and Effects on Diagnosis of Myocardial Infarction. Zachoval CF, Dolscheid-Pommerich R, Graeff I, Goldschmidt B, Grigull A, Stoffel-Wagner B, Nickenig G, Zimmer S J Clin Med. 2020 Mar 12;9(3):775. doi: 10.3390/jcm9030775.

Interpreting the Benefit of Simvastatin-Ezetimibe in Patients 75 Years or Older. Weingärtner O, Sijbrands EJG, Lütjohann D JAMA Cardiol. 2020 Feb 1;5(2):234. doi: 10.1001/jamacardio.2019.5197.

Evidence for shrunken pore syndrome in children. den Bakker E, Gemke RJ, van Wijk JA, Hubeek I, Stoffel-Wagner B, Bökenkamp A Scand J Clin Lab Invest. 2020 Feb;80(1):32-38. doi: 10.1080/00365513.2019.1692231.

Levels of 7alpha-hydroxycholesterol and/or 7alpha-hydroxy-4-cholest-3-one are the optimal biochemical markers for the evaluation of treatment of cerebrotendinous xanthomatosis. Lütjohann D, Stellaard F, Björkhem I J Neurol. 2020 Feb;267(2):572-573. doi: 10.1007/s00415-019-09650-0.

Phenprocoumon Dose Requirements, Dose Stability and Time in Therapeutic Range in Elderly Patients With CYP2C9 and VKORC1 Polymorphisms. Schneider KL, Kunst M, Leuchs AK, Böhme M, Weckbecker K, Kastenmüller K, Bleckwenn M, Holdenrieder S, Coch C, Hartmann G, Stingl JC Front Pharmacol. 2020 Jan 28;10:1620. doi: 10.3389/fphar.2019.01620.

Optimizing Clinical Cardiovascular Outcomes by a Personalized Approach to Add Ezetimibe to a Statin. Weingärtner O, Sijbrands EJG, Lütjohann D J Am Coll Cardiol. 2020 Jan 7;75(1):128. doi: 10.1016/j.jacc.2019.08.1072.

Interaction of chylomicron remnants and VLDLs during ultracentrifuge separation based on the Svedberg flotation rate. Stellaard F, Lütjohann D J Intern Med. 2020 Jan;287(1):117. doi: 10.1111/joim.13000.

Rare dyslipidaemias, from phenotype to genotype to management: a European Atherosclerosis Society task force consensus statement. Hegele RA, Borén J, Ginsberg HN, Arca M, Averna M, Binder CJ, Calabresi L, Chapman MJ, Cuchel M, von Eckardstein A, Frikke-Schmidt R, Gaudet D, Hovingh GK, Kronenberg F, Lütjohann D, Parhofer KG, Raal FJ, Ray KK, Remaley AT, Stock JK, Stroes ES, Tokgözoğlu L, Catapano AL Lancet Diabetes Endocrinol. 2020 Jan;8(1):50-67. doi: 10.1016/S2213-8587(19)30264-5.

Acute Impact of Dietary Pattern and Walking on Postprandial Attention, Mood, and Satiety in Older Adults: A Randomized Crossover Trial. Diekmann C, Wagner M, Huber H, Preuß M, Preuß P, Predel HG, Stoffel-Wagner B, Fimmers R, Stehle P, Egert S Nutrients. 2019 Sep 26;11(10). pii: E2294. doi: 10.3390/nu11102294.

Health-related quality of life and neurocognitive functioning with lomustine-temozolomide versus temozolomide in patients with newly diagnosed, MGMT-methylated glioblastoma (CeTeG/NOA-09): a randomised, multicentre, open-label, phase 3 trial. Weller J, Tzaridis T, Mack F, Steinbach JP, Schlegel U, Hau P, Krex D, Grauer O, Goldbrunner R, Bähr O, Uhl M, Seidel C, Tabatabai G, Brehmer S, Bullinger L, Galldiks N, Schaub C, Kebir S, Stummer W, Simon M, Fimmers R, Coch C, Glas M, Herrlinger U, Schäfer N. Lancet Oncol. 2019 Sep 2. pii: S1470-2045(19)30502-9. doi: 10.1016/S1470-2045(19)30502-9. [Epub ahead of print]

Monozygotic Twins with Birth-Weight Differences: Metabolic Health Influenced more by Genetics or by Environment? Grunewald M, Schulte S, Bartmann P, Stoffel-Wagner B, Fimmers R, Woelfle J, Gohlke B. Horm Res Paediatr. 2019 Aug 14:1-9. doi: 10.1159/000501775. [Epub ahead of print]

Thyroid Function in Monozygotic Twins with Intra-twin Birth Weight Differences: A Prospective Longitudinal Cohort Study. Schulte S, Gohlke B, Schreiner F, Gruenewald M, Fimmers R, Stoffel-Wagner B, Bartmann P, Woelfle J. J Pediatr. 2019 Aug;211:164-171. doi: 10.1016/j.jpeds.2019.03.041.

Need to individualise cholesterol-lowering therapy. Lütjohann D, Weingärtner O, Heart 2019 Aug;105(16):1291-1292. doi: 10.1136/heartjnl-2019-315376.

Moderate Postmeal Walking Has No Beneficial Effects Over Resting on Postprandial Lipemia, Glycemia, Insulinemia, and Selected Oxidative and Inflammatory Parameters in Older Adults with a Cardiovascular Disease Risk Phenotype: A Randomized Crossover Trial. Diekmann C, Huber H, Preuß M, Preuß P, Predel HG, Stoffel-Wagner B, Fimmers R, Stehle P, Egert S, J Nutr. 2019 Jul 18. pii: nxz148. doi: 10.1093/jn/nxz148. [Epub ahead of print]

In vitro effects of sitosterol and sitostanol on mitochondrial respiration in human brown adipocytes, myotubes and hepatocytes. Nascimento EBM, Konings M, Schaart G, Groen AK, Lütjohann D, van Marken Lichtenbelt WD, Schrauwen P, Plat J, Eur J Nutr. 2019 Jul 17. doi: 10.1007/s00394-019-02052-y. [Epub ahead of print].

Frequent detection of Saffold cardiovirus in adenoids. Lindner K, Ludwig M, Bootz F, Reber U, Safavieh Z, Eis-Hübinger AM, Herberhold S, PLoS One. 2019 Jul 3;14(7):e0218873. doi: 10.1371/journal.pone.0218873.

Exome chip association study excluded the involvement of rare coding variants with large effect sizes in the etiology of anorectal malformations. van de Putte R, Wijers CHW, Reutter H, Vermeulen SH, Marcelis CLM, Brosens E, Broens PMA, Homberg M, Ludwig M, Jenetzky E, Zwink N, Sloots CEJ, de Klein A, Brooks AS, Hofstra RMW, Holsink SAC, van der Zanden LFM, Galesloot TE, Tam PK, Steehouwer M, Acuna-Hidalgo R, Vorst MV, Kiemeney LA, Garcia-Barceló MM, de Blaauw I, Brunner HG, Roeleveld N, van Rooij IALM. PLoS One. 2019 May 28;14:e0217477. doi: 10.1371/journal.pone.0217477. eCollection 2019.

Rare Variants in BNC2 Are Implicated in Autosomal-Dominant Congenital Lower Urinary-Tract Obstruction. Kolvenbach CM, Dworschak GC, Frese S, Japp AS, Schuster P, Wenzlitschke N, Yilmaz Ö, Lopes FM, Pryalukhin A, Schierbaum L, van der Zanden LFM, Kause F, Schneider R, Taranta-Janusz K, Szczepańska M, Pawlaczyk K, Newman WG, Beaman GM, Stuart HM, Cervellione RM, Feitz WFJ, van Rooij IALM, Schreuder MF, Steffens M, Weber S, Merz WM, Feldkötter M, Hoppe B, Thiele H, Altmüller J, Berg C, Kristiansen G, Ludwig M, Reutter H, Woolf AS, Hildebrandt F, Grote P, Zaniew M, Odermatt B, Hilger AC. Am J Hum Genet. 2019 May 2;104:994-1006. doi: 10.1016/j.ajhg.2019.03.023.

Besnoitia besnoiti infection alters both endogenous cholesterol de novo synthesis and exogenous LDL uptake in host endothelial cells. Silva LMR, Lütjohann D, Hamid P, Velasquez ZD, Kerner K, Larrazabal C, Failing K, Hermosilla C, Taubert A. Sci Rep. 2019 Apr 30;9:6650. doi: 10.1038/s41598-019-43153-2.

Low serum lathosterol levels associate with fatal cardiovascular disease and excess all-cause mortality: a prospective cohort study. Weingärtner O, Lütjohann D, Meyer S, Fuhrmann A, Cremers B, Seiler-Mußler S, Schött HF, Kerksiek A, Friedrichs S, Ulbricht U, Zawada A, Laufs U, Schulze PC, Scheller B, Fliser D, Böhm M, Sijbrands E, Heine GH. Clin Res Cardiol. 2019 Apr 4. doi: 10.1007/s00392-019-01474-2.

Direct RIG-I activation in human NK cells induces TRAIL-dependent cytotoxicity toward autologous melanoma cells. Daßler-Plenker J, Paschen A, Putschli B, Rattay S, Schmitz S, Goldeck M, Bartok E, Hartmann G, Coch C. Int J Cancer 2019 Apr 1;144(7):1645-1656. doi: 10.1002/ijc.31874. Epub 2019 Jan 9.

First international descriptive and interventional survey for cholesterol and non-cholesterol sterol determination by gas- and liquid-chromatography-Urgent need for harmonisation of analytical methods. Lütjohann D, Björkhem I, Friedrichs S, Kerksiek A, Lövgren-Sandblom A, Geilenkeuser WJ, Ahrends R, Andrade I, Ansorena D, Astiasarán I, Baila-Rueda L, Barriuso B, Becker S, Bretillon L, Browne RW, Caccia C, Ceglarek U, Cenarro A, Crick PJ, Fauler G, Garcia-Llatas G, Gray R, Griffiths WJ, Gylling H, Harding S, Helmschrodt C, Iuliano L, Janssen HG, Jones P, Kaipiainen L, Kannenberg F, Lagarda MJ, Leoni V, Lottenberg AM, MacKay DS, Matysik S, McDonald J, Menendez-Carreño M, Myrie SB, Sutti Nunes V, Ostlund RE, Polisecki E, Ramos F, Rideout TC, Schaefer EJ, Schmitz G, Wang Y, Zerbinati C, Diczfalusy U, Schött HF. J Steroid Biochem Mol Biol. 2019 Mar 30;190:115-125. doi: 10.1016/j.jsbmb.2019.03.025.

Human TLR8 Senses RNA From Plasmodium falciparum-Infected Red Blood Cells Which Is Uniquely Required for the IFN-γ Response in NK Cells. Coch C, Hommertgen B, Zillinger T, Daßler-Plenker J, Putschli B, Nastaly M, Kümmerer BM, Scheunemann JF, Schumak B, Specht S, Schlee M, Barchet W, Hoerauf A, Bartok E, Hartmann G. Front Immunol. 2019 Mar 27;10:371. doi: 10.3389/fimmu.2019.00371. eCollection 2019.

Dietary Sargassum fusiforme improves memory and reduces amyloid plaque load in an Alzheimer's disease mouse model. Bogie J, Hoeks C, Schepers M, Tiane A, Cuypers A, Leijten F, Chintapakorn Y, Suttiyut T, Pornpakakul S, Struik D, Kerksiek A, Liu HB, Hellings N, Martinez-Martinez P, Jonker JW, Dewachter I, Sijbrands E, Walter J, Hendriks J, Groen A, Staels B, Lütjohann D, Vanmierlo T, Mulder M. Sci Rep. 2019 Mar 20;9(1):4908. doi: 10.1038/s41598-019-41399-4.

HSPA6: A new autosomal recessive candidate gene for the VATER/VACTERL malformation spectrum. Kause F, Zhang R, Ludwig M, Schmiedeke E, Rissmann A, Thiele H, Altmueller J, Herms S, Hilger AC, Hildebrandt F, Reutter H. Birth Defects Res. 2019 Mar 18. doi: 10.1002/bdr2.1493.

The isoflavones genistein and daidzein increase hepatic concentration of thyroid hormones and affect cholesterol metabolism in middle-aged male rats. Šošić-Jurjević B, Lütjohann D, Renko K, Filipović B, Radulović N, Ajdžanović V, Trifunović S, Nestorović N, Živanović J, Manojlović Stojanoski M, Kӧhrle J, Milošević V. J Steroid Biochem Mol Biol. 2019 Mar 15;190:1-10. doi: 10.1016/j.jsbmb.2019.03.009.

The emerging concept of "individualized cholesterol-lowering therapy": A change in paradigm. Lütjohann D, Stellaard F, Mulder MT, Sijbrands EJG, Weingärtner O. Pharmacol Ther. 2019 Mar 12. pii: S0163-7258(19)30043-9. doi: 10.1016/j.pharmthera.2019.03.004.

Targeted Nanoparticle Delivery of Bifunctional RIG-I Agonists to Pancreatic Cancer. Zillinger T, Hartmann G. Mol Ther. 2019 Mar 6;27(3):491-492. doi: 10.1016/j.ymthe.2019.02.005. Epub 2019 Feb 20. 

Haematopoietic alterations in neonates with congenital diaphragmatic hernia receiving extracorporeal membrane oxygenation support. Dolscheid-Pommerich RC, Kreuzer A, Graeff I, Stoffel-Wagner B, Mueller A, Kipfmueller F. Ann Clin Biochem. 2019 Mar;56(2):247-252. doi: 10.1177/0004563218820052. Epub 2019 Feb 24.

Effect of transcutaneous vagus nerve stimulation on muscle activity in the gastrointestinal tract (transVaGa): a prospective clinical trial. Hong GS, Pintea B, Lingohr P, Coch C, Randau T, Schaefer N, Wehner S, Kalff JC, Pantelis D. Int J Colorectal Dis. 2019 Mar;34(3):417-422. doi: 10.1007/s00384-018-3204-6. Epub 2018 Dec 5.

Plant-based sterols and stanols in health & disease: "Consequences of human development in a plant-based environment?" Plat J, Baumgartner S, Vanmierlo T, Lütjohann D, Calkins KL, Burrin DG, Guthrie G, Thijs C, Te Velde AA, Vreugdenhil ACE, Sverdlov R, Garssen J, Wouters K, Trautwein EA, Wolfs TG, van Gorp C, Mulder MT, Riksen NP, Groen AK, Mensink RP. Prog Lipid Res. 2019 Feb 26;74:87-102. doi: 10.1016/j.plipres.2019.02.003.

Saliva molecular inflammatory profiling in female migraine patients responsive to adjunctive cervical non-invasive vagus nerve stimulation: the MOXY Study. Boström A, Scheele D, Stoffel-Wagner B, Hönig F, Chaudhry SR, Muhammad S, Hurlemann R, Krauss JK, Lendvai IS, Chakravarthy KV, Kinfe TM. J Transl Med. 2019 Feb 22;17(1):53. doi: 10.1186/s12967-019-1801-y.

Lomustine-temozolomide combination therapy versus standard temozolomide therapy in patients with newly diagnosed glioblastoma with methylated MGMT promoter (CeTeG/NOA-09): a randomised, open-label, phase 3 trial. Herrlinger U, Tzaridis T, Mack F, Steinbach JP, Schlegel U, Sabel M, Hau P, Kortmann RD, Krex D, Grauer O, Goldbrunner R, Schnell O, Bähr O, Uhl M, Seidel C, Tabatabai G, Kowalski T, Ringel F, Schmidt-Graf F, Suchorska B, Brehmer S, Weyerbrock A, Renovanz M, Bullinger L, Galldiks N, Vajkoczy P, Misch M, Vatter H, Stuplich M, Schäfer N, Kebir S, Weller J, Schaub C, Stummer W, Tonn JC, Simon M, Keil VC, Nelles M, Urbach H, Coenen M, Wick W, Weller M, Fimmers R, Schmid M, Hattingen E, Pietsch T, Coch C, Glas M; Neurooncology Working Group of the German Cancer Society. Lancet 2019 Feb 16;393(10172):678-688. doi: 10.1016/S0140-6736(18)31791-4. Epub 2019 Feb 14.

Impact of a Usual Serving Size of Flavanol-Rich Cocoa Powder Ingested with a Diabetic-Suitable Meal on Postprandial Cardiometabolic Parameters in Type 2 Diabetics-A Randomized, Placebo-Controlled, Double-Blind Crossover Study. Rynarzewski J, Dicks L, Zimmermann BF, Stoffel-Wagner B, Ludwig N, Helfrich HP, Ellinger S. Nutrients 2019 Feb 16;11(2). pii: E417. doi: 10.3390/nu11020417.

Trauma Disclosure Moderates the Effects of Oxytocin on Intrusions and Neural Responses to Fear. Scheele D, Lieberz J, Goertzen-Patin A, Engels C, Schneider L, Stoffel-Wagner B, Becker B, Hurlemann R. Psychother Psychosom. 2019;88(1):61-63. doi: 10.1159/000496056. Epub 2019 Jan 24.

Selective L4 Dorsal Root Ganglion Stimulation Evokes Pain Relief and Changes of Inflammatory Markers: Part I Profiling of Saliva and Serum Molecular Patterns. Gravius N, Chaudhry SR, Muhammad S, Boström A, Gravius S, Randau T, Scheele D, Westhofen P, Kruppenbacher J, Stoffel-Wagner B, Maier C, Weidlich A, Yearwood TL, Chakravarthy KV, Kramer JM, Hurlemann R, Kinfe TM. Neuromodulation 2019 Jan;22(1):44-52. doi: 10.1111/ner.12866. Epub 2018 Oct 25.

Oxytocin enhances the pain-relieving effects of social support in romantic couples. Kreuder AK, Wassermann L, Wollseifer M, Ditzen B, Eckstein M, Stoffel-Wagner B, Hennig J, Hurlemann R, Scheele D. Hum Brain Mapp. 2019 Jan;40(1):242-251. doi: 10.1002/hbm.24368. Epub 2018 Aug 28.

Oxytocin reduces a chemosensory-induced stress bias in social perception. Maier A, Scheele D, Spengler FB, Menba T, Mohr F, Güntürkün O, Stoffel-Wagner B, Kinfe TM, Maier W, Khalsa SS, Hurlemann R. Neuropsychopharmacology 2019 Jan;44(2):281-288. doi: 10.1038/s41386-018-0063-3. Epub 2018 Apr 12.

Stand 16.03.2022

Information gemäß § 6 Medizinprodukte-Betreiberverordnung "Beauftragter für Medizinproduktesicherheit"

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