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2023

20.12.2023

Dr. Yuta Tsukamoto received Young Researchers Excellent Presentation Award                                                       We proudly announce that Yuta has been one of the winners of the Young Researchers Excellent Presentation Award in 70th Annual Meeting of the Japanese Society for Virology (Sendai, Japan, Sep 2023). We congratulate him on this great and well deserved achievement. 

18.12.2023

Open Philanthropy has awarded us    with a grant of USD 2,200,000              to support optimization of a host-directed Influenza A antiviral               Open Philanthropy announced in their annual grant report the funding of our joint project with Prof. Christa Müller (Pharmaceutical & Medical Chemistry, University Bonn  ).                     Together, we aim to find new antiviral compounds to combat endemic and pandemic viral infections like Influenza A and B and others.   

12.12.2023

Recent review publication in the current journal of Cell Chemical Biology           We proudly announce the review publication of our dear colleague Yuta Tsukamoto in the current journal of Cell Chemical Biology. Based on his latest Science paper, Yuta now highlights the importance and potential of “Targeting cap1 RNA methyltransferases as an antiviral strategy”.                                     We congratulate him and his co-authors to this outline about the game-changing options in the treatment of viral infections.                     Publication: Targeting cap1 RNA methyltransferases as an antiviral strategy. Cell Chemical Biology. 2023 Dec 12. DOI: https://doi.org/10.1016/j.chembiol. 2023.11.011 

18.04.2023

Recent Publication at Kyoto University   Our cooperation partner Jung Hyun Im, member of the Fujita Laboratory at Kyoto University, was able to publish his scientific results in the journal Scientific Reports.                                               We sincerely congratulate him and are pleased to have supported his work.     He was able to show that the binding kinetics of double-stranded RNA molecules and RIG-I strongly depend on the size of the bound RNA molecule and could be an important factor in the initiation of effective antiviral signal transduction.                                      Publication: Mechanisms of length-dependent recognition of viral double-stranded RNA by RIG-I. Sci Rep. 2023 Apr 18;13(1):6318. 

17.04.2023

Glad to have you here!                           The "Cellular Virology" team is very happy to welcome Laura Pearson as a new PhD student! Laura has already experience with virology and extracellular vesicles and will now study the immunoregulation of the innate immune response in hepatitis virus infections.

08.03.2023

Research highlight in nature reviews drug discovery "Inhibiting cap snatching"                                               Yuta's recent paper has already been commented by Sarah Crunkhorn.           Have a look at the article "Inhibiting cap snatching".                Publication: Inhibition of cellular RNA methyltransferase abrogates influenza virus capping and replication. Science 379. 

02.03.2023

Publication with our Collaborator  Akihito Kira in the Journal European PMC   Congratulations to our collaborator Akihito Kira for his publication in the journal European PMC on March 2nd.   He was able to shed more light on the mechanism of extracellular vesicle formation and extrusion and we are very pleased that several of our lab members were able to participate in this scientific work.                     Publication: Extracellular vesicle formation mediated by local phosphatidylserine exposure promotes efficient cell extrusion. EPMC. preprint 2023 Mar 02. doi: 10.21203/rs.3.rs-257262/v2  

09.02.2023

Publication in the top journal "SCIENCE" - New compound inhibits influenza virus replication                                               We are delighted to announce the publication of our most recent paper in the top journal “SCIENCE”!                    The scientific results demonstrate that the replication of influenza viruses can be limited by a compound that inhibits the body's own methyltransferase MTr1, which has been identified by the team led by Prof. Hiroki Kato.                                                      We congratulate our Postdoc Dr. Yuta Tsukamoto, 1st Author, to this excellent scientific work and give our thanks to all those who participated in this achievement!                         Publication: Inhibition of cellular RNA methyltransferase abrogates influenza virus capping and replication. Science 379.                                                       Press release:                                            English  German  Twitter                 IAV replication in the presence or absence of MTr1: - The host RNA is methylated by MTr1 to a mature cap1 RNA. The influenza virus snatches the cap part of the mature host RNA to start viral replication. MTr1-deficient cells or cells treated with MTr1 inhibitors do not lead to IAV replication. © Image (created with BioRender.com): Yuta Tsukamoto/UKB

2022

08.11.2022

Publication at the Journal of Experimental Medicine                          We congratulate Tina Schumann from the AG Behrendt to a fantastic publication in the Journal of Experimental Medicine! We are very happy, that we experimentally could support her work. She investigated the impact of the phosphohydrolase SAMHD1 and the cGAS/STING pathway in the context of DNA damages and could show their importance in physiological and pathophysiological innate immune priming. 

27.10.2022

Another opportunity to celebrate              The Cellular Virology team is getting more research funding, we have successfully obtained a DFG grant for a PhD position. So if you are interested in the regulation of the innate immune response and antiviral signaling, we are looking forward to your application.

26.10.2022

SARS-CoV-2 publication in EMBO journal                                                        In thight collaboration with Prof. Thomas Gramberg at the virology department of the university clinics erlangen, we could publish this paper. The scientific results demonstrate that the SARS-CoV-2 viral 2'-O-methyltransferases Nsp16 firstly shields the viral RNA from recognition by MDA5 and  secondly from interferon-induced antiviral responses.

19.10.2022

Melatonin influences EMCV infections   Together with our collegues in japan we could publish a collaborative paper about the impact of the sleep hormon melatonin on the viral infection with EMCV. It was demonstrated that the viral particle uptake into macrophages as well as the cytoskeletal regulation was suppressed by melatonin.

04.10.2022

New member within the "Cellular Virology" team                                        Slowly but surely our familiar group is growing. Today we are delighted to welcome Annika Walter as a new PhD student. Annika is interested in studying the innate immune response to hepatitis B infection in a DZIF-funded project.

22.09.2022

Recent publication by the "Cellular Virology" team                                         It's not all about RIG-I like receptors and extracellular vesicles ... it can also be a Toll-like receptor, sometimes. Today, the Cellular Virology team publishes a paper on the immunomodulatory effect of 2'-O-ribose methylation on TLR7 and TLR8 activation in IJMS.

24.09.2022

Most recent publication at Kyoto University                                  Congratulations to Lianne Emralino to the accepted paper in the Journal of Immunology. Lianne is PhD-student at Kyoto University, one of our close collaborations. She last visited our lab in March 2019 and we are happy to announce her publication in the Journal of Immunology. She could characterize the pathogenic impact of the R822Q mutation in MDA5. 

19.09.2022

Another well deserved publication at Kyoto University                                   We are happy to announce the publication of Sumin Lee´s paper dealing with the regulatory function of MDA5 in an interferonopathy mouse model. Sumin is PhD-student at Kyoto University, one of our close collaborations. She visited our lab last in May and December 2018 and we happily announce her publication. 

19.09.2022

Publication with our Japanese collaborations                                         In tight collaboration with our Japanese colleagues, we could publish this paper. The scientific results demonstrate essential molecules in the process of RNA-mediated apoptosis of virally infected cells leading to the arrest of virus production. 

15.09.2022

Publication in the top journal NATURE! We congratulate Fotis Karagiannis in Chris Wilhelm´s group to this excellent scientific work and happily collaborated and participated at this publication. He could highlight the impact of impaired ketogenesis as a relevant factor in severe COVID-19 infections. The importance of these results are emphasized by the publication in the top journal NATURE! 

12.09.2022

Recent publication at The EMBO journal We proudly present our paper in tight collaboration with Andreas Pichlmair´s group at the TU Munich. In here, we could demonstrate that the concomitant targeting of host and viral methyltransferases can effectively suppress SARS-CoV-2 replication. 

18.04.2022

Joy again                                                   Today, the "Cellular Virology" team is really happy to welcome Helena Shkuro (Master Student of Biochemistry at the University of Bonn) for a lab rotation. Great to have you here, Helena!

01.02.2022

The latest news ...                                    Please check on pubmed for Hirokis latest contribution on the role of MDA5 in autoimmunity. 

2021

18.11.2021

Good news again                                      Today Basti, Stephanie and Ulla are pleased to announce that their latest paper on the immune response to hepatitis D virus infection has been accepted for publication in Cells.

07.10.2021

TRR237 Retreat at Schloss Ahrenthal Hiroki, Stephanie, and Domnica are attending the TRR237 retreat at Schloss Ahrenthal. Three days of listening to interesting science, meeting nice people and building helpful collaborations, staying in a castle, and going on the first business trip since the Corona pandemic began-you really can spend your time in more unpleasant ways.

14.09.2021

Julia presents at DGHM                           Julia has an oral presentation at the annual meeting of the DGHM (Deutsche Gesellschaft für Hygiene und Mikrobiologie): "Bacteriophages against Staphylococcus lugdunensis and their inhibitory effect on biofilms."

16.08.2021

New Team member "Cellular Virology" Today we officially welcome our new Team member Fiona, who joins our team as a Research Assistant for the next two months. Fiona has already completed her training as a Biological Technical Assistant with Stephanie in Munich and published a method for the separation of EVs and HBV. We are very happy to have you with us now, Fiona!

08.08.2021

First publication by the "Cellular Virology" Team                                         Congratulations to Julia and Timo for publishing their first paper, studying the generation of an endogenous RIG-I ligand in Influenza A virus-infected cells. You did a great and extremely efficient job, guys!

05.07.2021

New Team member                               Today we officially welcome our old New team member Andreas Limbach, who has been in our Lab for the last two rotations of his apprenticeship. He will join our team as a technician temporarily for the next three month. Welcome Andreas, we are happy to have you "back"!

 
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