Research
Our research focuses mainly on two main topics dealing with the analysis of molecular mechanismisms leading to autoimmune diseases (ADs) and the molecular mechanisms during viral recognition. In both processes cytoplasmic RNA sensors, namely RIG-I like receptors (RLRs), play a crucial role. Their role is more obvious in virus recognition since RLRs distinguish between viral RNAs and self-RNAs and trigger type I interferons (type I IFNs) as a defense mechanism. But it has also been found, that mutations in RLR lead to the development of several autoimmune diseases.
Please find more information about our research on the webpage of AG Kato.
Early virus-host interactions are an interplay of viral exploitation of cellular proteins, functions, and innate defence mechanisms. Our research aims at answering the following questions: Which mechanisms and specific patterns lead to the recognition of a viral infection? What does a virus do to evade this recognition? Which cellular structures resemble viruses? In which cells are viral infections actually recognized – the non-infected, or the infected ones? We are taking a closer look on the constant struggle between viruses and the immune system, with special emphasis on extracellular vesicles (EVs). In recent years, this new and highly interdisciplinary field has led to many surprising discoveries and shows a high potential for further scientific developments.
Please find more information about our research on the webpage of "Cellular Virology" team.
