Publications

For a complete list of publications please click here:
https://pubmed.ncbi.nlm.nih.gov/?term=Ruiz+de+Almodovar+C&sort=pubdate


Publications since 2013:

1         Karakatsani, A., Álvarez-Vergara, M. I. & Ruiz de Almodóvar, C. The vasculature of neurogenic niches: Properties and function. Cells Dev 174, 203841 (2023).  https://doi.org/10.1016/j.cdev.2023.203841

2         Vieira, J. R., Shah, B., Dupraz, S., Paredes, I., Himmels, P., Schermann, G., Adler, H., Motta, A., Gärtner, L., Navarro-Aragall, A., Ioannou, E., Dyukova, E., Bonnavion, R., Fischer, A., Bonanomi, D., Bradke, F., Ruhrberg, C. & Ruiz de Almodóvar, C. Endothelial PlexinD1 signaling instructs spinal cord vascularization and motor neuron development. Neuron 110, 4074-4089.e4076 (2022).  https://doi.org/10.1016/j.neuron.2022.12.005

3         Tisch, N., Mogler, C., Stojanovic, A., Luck, R., Korhonen, E. A., Ellerkmann, A., Adler, H., Singhal, M., Schermann, G., Erkert, L., Patankar, J. V., Karakatsani, A., Scherr, A. L., Fuchs, Y., Cerwenka, A., Wirtz, S., Köhler, B. C., Augustin, H. G., Becker, C., Schmidt, T. & Ruiz de Almodóvar, C. Caspase-8 in endothelial cells maintains gut homeostasis and prevents small bowel inflammation in mice. EMBO Mol Med 14, e14121 (2022).  https://doi.org/10.15252/emmm.202114121

4         Tisch, N. & Ruiz de Almodóvar, C. Contribution of cell death signaling to blood vessel formation. Cell Mol Life Sci 78, 3247-3264 (2021).  https://doi.org/10.1007/s00018-020-03738-x

5         Ripp, J., Kehrer, J., Smyrnakou, X., Tisch, N., Tavares, J., Amino, R., Ruiz de Almodovar, C. & Frischknecht, F. Malaria parasites differentially sense environmental elasticity during transmission. EMBO Mol Med 13, e13933 (2021).  https://doi.org/10.15252/emmm.202113933

6         Paredes, I., Vieira, J. R., Shah, B., Ramunno, C. F., Dyckow, J., Adler, H., Richter, M., Schermann, G., Giannakouri, E., Schirmer, L., Augustin, H. G. & Ruiz de Almodóvar, C. Oligodendrocyte precursor cell specification is regulated by bidirectional neural progenitor-endothelial cell crosstalk. Nat Neurosci 24, 478-488 (2021).  https://doi.org/10.1038/s41593-020-00788-z

7         Luck, R., Karakatsani, A., Shah, B., Schermann, G., Adler, H., Kupke, J., Tisch, N., Jeong, H. W., Back, M. K., Hetsch, F., D'Errico, A., De Palma, M., Wiedtke, E., Grimm, D., Acker-Palmer, A., von Engelhardt, J., Adams, R. H., Augustin, H. G. & Ruiz de Almodóvar, C. The angiopoietin-Tie2 pathway regulates Purkinje cell dendritic morphogenesis in a cell-autonomous manner. Cell Rep 36, 109522 (2021).  https://doi.org/10.1016/j.celrep.2021.109522

8         Jiang, X., Hu, J., Wu, Z., Cafarello, S. T., Di Matteo, M., Shen, Y., Dong, X., Adler, H., Mazzone, M., Ruiz de Almodovar, C. & Wang, X. Protein Phosphatase 2A Mediates YAP Activation in Endothelial Cells Upon VEGF Stimulation and Matrix Stiffness. Front Cell Dev Biol 9, 675562 (2021).   https://doi.org/10.3389/fcell.2021.675562

9          Vieira, J. R., Shah, B. & Ruiz de Almodovar, C. Cellular and Molecular Mechanisms of Spinal Cord Vascularization. Front Physiol 11, 599897 (2020).   https://doi.org/10.3389/fphys.2020.599897

10       Shen, Y., Wang, X., Lu, J., Salfenmoser, M., Wirsik, N. M., Schleussner, N., Imle, A., Freire Valls, A., Radhakrishnan, P., Liang, J., Wang, G., Muley, T., Schneider, M., Ruiz de Almodovar, C., Diz-Muñoz, A. & Schmidt, T. Reduction of Liver Metastasis Stiffness Improves Response to Bevacizumab in Metastatic Colorectal Cancer. Cancer Cell 37, 800-817.e807 (2020).  https://doi.org/10.1016/j.ccell.2020.05.005

11       Di Marco, B., Crouch, E. E., Shah, B., Duman, C., Paredes, M. F., Ruiz de Almodovar, C., Huang, E. J. & Alfonso, J. Reciprocal Interaction between Vascular Filopodia and Neural Stem Cells Shapes Neurogenesis in the Ventral Telencephalon. Cell Rep 33, 108256 (2020).  https://doi.org/10.1016/j.celrep.2020.108256

12       Tisch, N., Freire-Valls, A., Yerbes, R., Paredes, I., La Porta, S., Wang, X., Martín-Pérez, R., Castro, L., Wong, W. W., Coultas, L., Strilic, B., Gröne, H. J., Hielscher, T., Mogler, C., Adams, R. H., Heiduschka, P., Claesson-Welsh, L., Mazzone, M., López-Rivas, A., Schmidt, T., Augustin, H. G. & Ruiz de Almodovar, C. Caspase-8 modulates physiological and pathological angiogenesis during retina development. J Clin Invest 129, 5092-5107 (2019).  https://doi.org/10.1172/jci122767

13       Stöth, M., Freire Valls, A., Chen, M., Hidding, S., Knipper, K., Shen, Y., Klose, J., Ulrich, A., Ruiz de Almodovar, C., Schneider, M. & Schmidt, T. Splenectomy reduces lung metastases and tumoral and metastatic niche inflammation. Int J Cancer 145, 2509-2520 (2019). https://doi.org/10.1002/ijc.32378

14       Luck, R., Urban, S., Karakatsani, A., Harde, E., Sambandan, S., Nicholson, L., Haverkamp, S., Mann, R., Martin-Villalba, A., Schuman, E. M., Acker-Palmer, A. & Ruiz de Almodóvar, C. VEGF/VEGFR2 signaling regulates hippocampal axon branching during development. Elife 8 (2019).  https://doi.org/10.7554/eLife.49818

15       Karakatsani, A., Shah, B. & Ruiz de Almodovar, C. Blood Vessels as Regulators of Neural Stem Cell Properties. Front Mol Neurosci 12, 85 (2019).  https://doi.org/10.3389/fnmol.2019.00085

16       Harde, E., Nicholson, L., Furones Cuadrado, B., Bissen, D., Wigge, S., Urban, S., Segarra, M., Ruiz de Almodóvar, C. & Acker-Palmer, A. EphrinB2 regulates VEGFR2 during dendritogenesis and hippocampal circuitry development. Elife 8 (2019).  https://doi.org/10.7554/eLife.49819

17       Freire Valls, A., Knipper, K., Giannakouri, E., Sarachaga, V., Hinterkopf, S., Wuehrl, M., Shen, Y., Radhakrishnan, P., Klose, J., Ulrich, A., Schneider, M., Augustin, H. G., Ruiz de Almodovar, C. & Schmidt, T. VEGFR1(+) Metastasis-Associated Macrophages Contribute to Metastatic Angiogenesis and Influence Colorectal Cancer Patient Outcome. Clin Cancer Res 25, 5674-5685 (2019).  https://doi.org/10.1158/1078-0432.Ccr-18-2123

18       Wirthschaft, P., Bode, J., Simon, A. E. M., Hoffmann, E., van Laack, R., Krüwel, T., Dietrich, F., Bucher, D., Hahn, A., Sahm, F., Breckwoldt, M. O., Kurz, F. T., Hielscher, T., Fischer, B., Dross, N., Ruiz de Almodovar, C., von Deimling, A., Herold-Mende, C., Plass, C., Boulant, S., Wiestler, B., Reifenberger, G., Lichter, P., Wick, W. & Tews, B. A PRDX1-p38α heterodimer amplifies MET-driven invasion of IDH-wildtype and IDH-mutant gliomas. Int J Cancer 143, 1176-1187 (2018).  https://doi.org/10.1002/ijc.31404

19        Paredes, I., Himmels, P. & Ruiz de Almodóvar, C. Neurovascular Communication during CNS Development. Dev Cell 45, 10-32 (2018).  https://doi.org/10.1016/j.devcel.2018.01.023

20       Katsinelos, T., Zeitler, M., Dimou, E., Karakatsani, A., Müller, H. M., Nachman, E., Steringer, J. P., Ruiz de Almodovar, C., Nickel, W. & Jahn, T. R. Unconventional Secretion Mediates the Trans-cellular Spreading of Tau. Cell Rep 23, 2039-2055 (2018).  https://doi.org/10.1016/j.celrep.2018.04.056

21       Atienzar-Aroca, S., Serrano-Heras, G., Freire Valls, A., Ruiz de Almodovar, C., Muriach, M., Barcia, J. M., Garcia-Verdugo, J. M., Romero, F. J. & Sancho-Pelluz, J. Role of retinal pigment epithelium-derived exosomes and autophagy in new blood vessel formation. J Cell Mol Med 22, 5244-5256 (2018).  https://doi.org/10.1111/jcmm.13730

22       Wang, X., Freire Valls, A., Schermann, G., Shen, Y., Moya, I. M., Castro, L., Urban, S., Solecki, G. M., Winkler, F., Riedemann, L., Jain, R. K., Mazzone, M., Schmidt, T., Fischer, T., Halder, G. & Ruiz de Almodóvar, C. YAP/TAZ Orchestrate VEGF Signaling during Developmental Angiogenesis. Dev Cell 42, 462-478.e467 (2017).  https://doi.org/10.1016/j.devcel.2017.08.002

23       Karakatsani, A., Marichal, N., Urban, S., Kalamakis, G., Ghanem, A., Schick, A., Zhang, Y., Conzelmann, K. K., Rüegg, M. A., Berninger, B., Ruiz de Almodovar, C., Gascón, S. & Kröger, S. Neuronal LRP4 regulates synapse formation in the developing CNS. Development 144, 4604-4615 (2017).  https://doi.org/10.1242/dev.150110

24       Himmels, P., Paredes, I., Adler, H., Karakatsani, A., Luck, R., Marti, H. H., Ermakova, O., Rempel, E., Stoeckli, E. T. & Ruiz de Almodóvar, C. Motor neurons control blood vessel patterning in the developing spinal cord. Nat Commun 8, 14583 (2017).  https://doi.org/10.1038/ncomms14583

25       Chen, S., Tisch, N., Kegel, M., Yerbes, R., Hermann, R., Hudalla, H., Zuliani, C., Gülcüler, G. S., Zwadlo, K., von Engelhardt, J., Ruiz de Almodóvar, C. & Martin-Villalba, A. CNS Macrophages Control Neurovascular Development via CD95L. Cell Rep 19, 1378-1393 (2017).  https://doi.org/10.1016/j.celrep.2017.04.056

26       Segura, I., Lange, C., Knevels, E., Moskalyuk, A., Pulizzi, R., Eelen, G., Chaze, T., Tudor, C., Boulegue, C., Holt, M., Daelemans, D., Matondo, M., Ghesquière, B., Giugliano, M., Ruiz de Almodovar, C., Dewerchin, M. & Carmeliet, P. The Oxygen Sensor PHD2 Controls Dendritic Spines and Synapses via Modification of Filamin A. Cell Rep 14, 2653-2667 (2016).  https://doi.org/10.1016/j.celrep.2016.02.047

27       Schmitz, R., Valls, A. F., Yerbes, R., von Richter, S., Kahlert, C., Loges, S., Weitz, J., Schneider, M., Ruiz de Almodovar, C., Ulrich, A. & Schmidt, T. TAM receptors Tyro3 and Mer as novel targets in colorectal cancer. Oncotarget 7, 56355-56370 (2016).  https://doi.org/10.18632/oncotarget.10889

28      Savant, S., La Porta, S., Budnik, A., Busch, K., Hu, J., Tisch, N., Korn, C., Valls, A. F., Benest, A. V., Terhardt, D., Qu, X., Adams, R. H., Baldwin, H. S., Ruiz de Almodóvar, C., Rodewald, H. R. & Augustin, H. G. The Orphan Receptor Tie1 Controls Angiogenesis and Vascular Remodeling by Differentially Regulating Tie2 in Tip and Stalk Cells. Cell Rep 12, 1761-1773 (2015).  https://doi.org/10.1016/j.celrep.2015.08.024

29       Kessler, T., Sahm, F., Blaes, J., Osswald, M., Rübmann, P., Milford, D., Urban, S., Jestaedt, L., Heiland, S., Bendszus, M., Hertenstein, A., Pfenning, P. N., Ruiz de Almodóvar, C., Wick, A., Winkler, F., von Deimling, A., Platten, M., Wick, W. & Weiler, M. Glioma cell VEGFR-2 confers resistance to chemotherapeutic and antiangiogenic treatments in PTEN-deficient glioblastoma. Oncotarget 6, 31050-31068 (2015).  https://doi.org/10.18632/oncotarget.2910

30       Hacke, M., Björkholm, P., Hellwig, A., Himmels, P., Ruiz de Almodóvar, C., Brügger, B., Wieland, F. & Ernst, A. M. Inhibition of Ebola virus glycoprotein-mediated cytotoxicity by targeting its transmembrane domain and cholesterol. Nat Commun 6, 7688 (2015).  https://doi.org/10.1038/ncomms8688

31       de Araújo Farias, V., O'Valle, F., Lerma, B. A., Ruiz de Almodóvar, C., López-Peñalver, J. J., Nieto, A., Santos, A., Fernández, B. I., Guerra-Librero, A., Ruiz-Ruiz, M. C., Guirado, D., Schmidt, T., Oliver, F. J. & Ruiz de Almodóvar, J. M. Human mesenchymal stem cells enhance the systemic effects of radiotherapy. Oncotarget 6, 31164-31180 (2015).  https://doi.org/10.18632/oncotarget.5216

32       Snuderl, M., Batista, A., Kirkpatrick, N. D., Ruiz de Almodovar, C., Riedemann, L., Walsh, E. C., Anolik, R., Huang, Y., Martin, J. D., Kamoun, W., Knevels, E., Schmidt, T., Farrar, C. T., Vakoc, B. J., Mohan, N., Chung, E., Roberge, S., Peterson, T., Bais, C., Zhelyazkova, B. H., Yip, S., Hasselblatt, M., Rossig, C., Niemeyer, E., Ferrara, N., Klagsbrun, M., Duda, D. G., Fukumura, D., Xu, L., Carmeliet, P. & Jain, R. K. Targeting placental growth factor/neuropilin 1 pathway inhibits growth and spread of medulloblastoma. Cell 152, 1065-1076 (2013).  https://doi.org/10.1016/j.cell.2013.01.036

33       Santos, R., Ruiz de Almodóvar, C., Bulteau, A. L. & Gomes, C. M. Neurodegeneration, neurogenesis, and oxidative stress. Oxid Med Cell Longev 2013, 730581 (2013).  https://doi.org/10.1155/2013/730581

34       Lelli, A., Gervais, A., Colin, C., Chéret, C., Ruiz de Almodovar, C., Carmeliet, P., Krause, K. H., Boillée, S. & Mallat, M. The NADPH oxidase Nox2 regulates VEGFR1/CSF-1R-mediated microglial chemotaxis and promotes early postnatal infiltration of phagocytes in the subventricular zone of the mouse cerebral cortex. Glia 61, 1542-1555 (2013).  https://doi.org/10.1002/glia.22540

35       Carmeliet, P. & Ruiz de Almodovar, C. VEGF ligands and receptors: implications in neurodevelopment and neurodegeneration. Cell Mol Life Sci 70, 1763-1778 (2013).  https://doi.org/10.1007/s00018-013-1283-7

36       Bono, F., De Smet, F., Herbert, C., De Bock, K., Georgiadou, M., Fons, P., Tjwa, M., Alcouffe, C., Ny, A., Bianciotto, M., Jonckx, B., Murakami, M., Lanahan, A. A., Michielsen, C., Sibrac, D., Dol-Gleizes, F., Mazzone, M., Zacchigna, S., Herault, J. P., Fischer, C., Rigon, P., Ruiz de Almodovar, C., Claes, F., Blanc, I., Poesen, K., Zhang, J., Segura, I., Gueguen, G., Bordes, M. F., Lambrechts, D., Broussy, R., van de Wouwer, M., Michaux, C., Shimada, T., Jean, I., Blacher, S., Noel, A., Motte, P., Rom, E., Rakic, J. M., Katsuma, S., Schaeffer, P., Yayon, A., Van Schepdael, A., Schwalbe, H., Gervasio, F. L., Carmeliet, G., Rozensky, J., Dewerchin, M., Simons, M., Christopoulos, A., Herbert, J. M. & Carmeliet, P. Inhibition of tumor angiogenesis and growth by a small-molecule multi-FGF receptor blocker with allosteric properties. Cancer Cell 23, 477-488 (2013).  https://doi.org/10.1016/j.ccr.2013.02.019