Clinical Research

Glioblastoma

Patterns, predictors and prognostic relevance of high-grade hematotoxicity after temozolomide or temozolomide-lomustine in the CeTeG/NOA-09 trial
Johannes Weller, Niklas Schäfer, Christina Schaub, Theophilos Tzaridis, Thomas Zeyen, Matthias Schneider, Anna-Laura Potthoff, Frank A. Giordano, Joachim P. Steinbach, Pia S. Zeiner, Thomas Kowalski, Michael Sabel, Peter Hau, Dietmar Krex, Oliver Grauer, Roland Goldbrunner, Oliver Schnell, Ghazalah Tabatabai, Florian Ringel, Friederike Schmidt-Graf, Stefanie Brehmer, Jörg-Christian Tonn, Lars Bullinger, Peter Vajkoczy, Martin Glas, Hartmut Vatter, Ulrich Herrlinger, Clemens Seidel
Journal of Neuro-Oncology, 2023

Unplanned intensive care unit readmission after surgical treatment in patients with newly diagnosed glioblastoma - forfeiture of surgically achieved advantages?
Felix Lehmann, Anna-Laura Potthoff, Valeri Borger, Muriel Heimann, Stefan Felix Ehrentraut, Christina Schaub, Christian Putensen, Johannes Weller, Christian Bode, Hartmut Vatter, Ulrich Herrlinger, Patrick Schuss, Niklas Schäfer, Matthias Schneider
Neurosurgical Review, 2023

Prognostic impact of obesity in newly-diagnosed glioblastoma: a secondary analysis of CeTeG/NOA-09 and GLARIUS
Johannes Weller, Niklas Schäfer, Christina Schaub, Anna‐Laura Potthoff, Joachim P. Steinbach, Uwe Schlegel, Michael Sabel, Peter Hau, Clemens Seidel, Dietmar Krex, Roland Goldbrunner, Torsten Pietsch, Theophilos Tzaridis, Thomas Zeyen, Valeri Borger, Erdem Güresir, Hartmut Vatter, Ulrich Herrlinger, Matthias Schneider
Journal of Neuro-Oncology, 2022

Chasing a rarity: a retrospective single-center evaluation of prognostic factors in primary gliosarcoma
Cas S. Dekonckheere, Alexander M. C. Böhner, David Koch, Leonard C. Schmeel, Ulrich Herrlinger, Hartmut Vatter, Matthias Schneider, Patrick, Schuss, Frank A. Giordano, Mümtaz A. Köksal
Strahlentherapie und Onkologie, 2021

Dosimetric Comparison of Upfront Boosting With Stereotactic Radiosurgery Versus Intraoperative Radiotherapy for Glioblastoma
Gustavo R. Sarria, Zuzanna Smalec, Thomas Muedder, Jasmin A. Holz, Davide Scafa, David Koch, Stephan Garbe, Matthias Schneider, Motaz Hamed, Hartmut Vatter, Ulrich Herrlinger, Frank A. Giordano, Leonard C. Schmeel
Frontiers in Oncology, 2021

Red blood cell distribution width to platelet ratio substantiates preoperative survival prediction in patients with newly-diagnosed glioblastoma
Matthias Schneider, Niklas Schäfer, Stefanos Apallas, Anna‐Laura Potthoff, Christian Bode, Erdem Güresir, Muriel Heimann, Felix Lehmann, Elisa Scharnböck, Christina Schaub, Hartmut Vatter, Ulrich Herrlinger, Patrick Schuss
Journal of Neuro-Oncology, 2021

Perioperative red blood cell transfusion is associated with poor functional outcome and overall survival in patients with newly diagnosed glioblastoma
Matthias Schneider, Niklas Schäfer, Anna‐Laura Potthoff, Leonie Weinhold, Lars Eichhorn, Johannes Weller, Elisa Scharnböck, Christina Schaub, Muriel Heimann, Erdem Güresir, Felix Lehmann, Hartmut Vatter, Ulrich Herrlinger, Patrick Schuss
Neurosurgical Review, 2021

Implementation, relevance, and virtual adaptation of neuro‐oncological tumor boards during the COVID‐19 pandemic: a nationwide provider survey
Niklas Schäfer, Elisabeth Bumes, Fabian Eberle, Viola Fox, Florian Gessler, Frank A. Giordano, Juergen Konczalla, Julia Onken, Malte Ottenhausen, Moritz Scherer, Matthias Schneider, Hartmut Vatter, Ulrich Herrlinger, Patrick Schuss
Journal of Neuro-Oncology, 2021

Seizure outcome in temporal glioblastoma surgery: lobectomy as a supratotal resection regime outclasses conventional gross‐total resection
Valeri Borger, Motaz Hamed, Inja Ilic, Anna‐Laura Potthoff, Attila Racz, Niklas Schäfer, Erdem Güresir, Rainer Surges, Ulrich Herrlinger, Hartmut Vatter, Matthias Schneider ‡, Patrick Schuss ‡; ‡ shared senior authorship
Journal of Neuro-Oncology, 2021

MGMT promoter methylation analysis for allocating combined CCNU/TMZ chemotherapy: Lessons learned from the CeTeG/NOA-09 trial
Theophilos Tzaridis, Niklas Schäfer, Johannes Weller, Joachim-Peter Steinbach, Uwe Schlegel, Sabine Seidel, Michael Sabel, Peter Hau, Clemens Seidel, Dietmar Krex, Roland Goldbrunner, Jörg-Christian Tonn, Oliver Grauer, Sied Kebir, Matthias Schneider, Christina Schaub, Hartmut Vatter, Christoph Coch, Martin Glas, Rolf Fimmers, Torsten Pietsch, Guido Reifenberger, Ulrich Herrlinger, Jörg Felsberg
International Journal of Cancer, 2020

Postoperative Prolonged Mechanical Ventilation in Patients With Newly Diagnosed Glioblastoma —An Unrecognized Prognostic Factor
Patrick Schuss, Felix Lehmann, Niklas Schäfer, Christian Bode, Elisa Scharnböck, Christina Schaub, Muriel Heimann, Anna-Laura Potthoff, Johannes Weller,
Erdem Güresir, Christian Putensen, Hartmut Vatter, Ulrich Herrlinger, Matthias Schneider
Frontiers in Oncology, 2020

Newly diagnosed glioblastoma in geriatric (65 +) patients: impact of patients frailty, comorbidity burden and obesity on overall survival
Matthias Schneider, Anna‐Laura Potthoff, Elisa Scharnböck, Muriel Heimann, Niklas Schäfer, Johannes Weller, Christina Schaub, Andreas H. Jacobs, Erdem Güresir, Ulrich Herrlinger, Hartmut Vatter, Patrick Schuss
Journal of Neuro-Oncology, 2020

Safety metric profiling in surgery for temporal glioblastoma: lobectomy as a supra‐total resection regime preserves perioperative standard quality rates
Matthias Schneider*, Inja Ilic*, Anna‐Laura Potthoff, Motaz Hamed, Niklas Schäfer, Markus Velten, Erdem Güresir, Ulrich Herrlinger, Valeri Borger, Hartmut Vatter, Patrick Schuss; *shared first authorship
Journal of Neuro-Oncology, 2020

Surgery for temporal glioblastoma: lobectomy outranks oncosurgical-based gross-total resection
Matthias Schneider, Anna‐Laura Potthoff, Vera C. Keil, Ági Güresir, Johannes Weller, Valeri Borger, Motaz Hamed, Andreas Waha, Hartmut Vatter, Erdem Güresir, Ulrich Herrlinger, Patrick Schuss
Journal of Neuro-Oncology, 2019

Meningioma

Surgery for posterior fossa meningioma: elevated postoperative cranial nerve morbidity discards aggressive tumor resection policy
Matthias Schneider, Patrick Schuss, Ági Güresir, Valeri Borger, Hartmut Vatter, Erdem Güresir
Neurosurgical Review, 2020

Outcome of Tumor-Associated Proptosis in Patients With Spheno-Orbital Meningioma: Single-Center Experience and Systematic Review of the Literature
Matthias Schneider, Anna-Laura Potthoff, Valeri Borger, Alexis Hadjiathanasiou, Niklas Schäfer, Ági Güresir, Hartmut Vatter, Ulrich Herrlinger, Erdem Güresir, Patrick Schuss
Frontiers in Oncology, 2020

Elevated body mass index facilitates early postoperative complications after surgery for intracranial meningioma
Matthias Schneider, Valeri Borger, Daniel Grigutsch, Ági Güresir, Anna-Laura Potthoff, Markus Velten, Hartmut Vatter, Erdem Güresir, Patrick Schuss
Neurosurgical Review, 2020

ACKT: A Proposal for a Novel Score to Predict Prolonged Mechanical Ventilation after Surgical Treatment of Meningioma in Geriatric Patients
Elisa Scharnböck, Leonie Weinhold, Anna-Laura Potthoff, Niklas Schäfer, Muriel Heimann, Felix Lehmann, Erdem Güresir, Christian Bode, Andreas H. Jacobs, Hartmut Vatter, Ulrich Herrlinger, Matthias Schneider ‡, Patrick Schuss ‡; ‡ shared senior authorship
Cancers, 2020

Cranial Nerve Outcomes After Surgery for Frontal Skull Base Meningiomas: The Eternal Quest of the Maximum-Safe Resection with the Lowest Morbidity
Matthias Schneider, Patrick Schuss, Ági Güresir, Johannes Wach, Motaz Hamed, Hartmut Vatter, Erdem Güresir
World Neurosurgery, 2019

Preoperative tumor-associated epilepsy in patients with supratentorial meningioma: factors influencing seizure outcome after meningioma surgery
Matthias Schneider, Ági Güresir, Valeri Borger, Motaz Hamed, Attila Rácz, Hartmut Vatter, Erdem Güresir, Patrick Schuss
Journal of Neurosurgery, 2019

High Mib-1-score correlates with new cranial nerve deficits after surgery for frontal skull base meningioma
Matthias Schneider, Valeri Borger, Ági Güresir, Albert Becker, Hartmut Vatter, Patrick Schuss, Erdem Güresir
Neurosurgical Review, 2019

Brain metastasis

Survival in patients with surgically treated brain metastases: does infratentorial location matter?
Motaz Hamed, Anna-Laura Potthoff, Muriel Heimann, Niklas Schäfer, Valeri Borger, Alexander Radbruch, Ulrich Herrlinger, Hartmut Vatter, Matthias Schneider
Neurosurgical Review, 2023

Survival after resection of brain metastasis: impact of synchronous versus metachronous metastatic disease
Anna-Laura Potthoff, Muriel Heimann, Felix Lehmann, Inja Ilic, Daniel Paech, Valeri Borger, Alexander Radbruch, Niklas Schäfer, Patrick Schuss, Hartmut Vatter, Ulrich Herrlinger, Matthias Schneider
Journal of Neuro-Oncology, 2023

Bone Mineral Density as an Individual Prognostic Biomarker in Patients with Surgically-Treated Brain Metastasis from Lung Cancer (NSCLC)
Inja Ilic, Anna-Laura Potthoff, Valeri Borger, Muriel Heimann, Daniel Paech, Frank A. Giordano, Leonard C. Schmeel, Alexander Radbruch, Patrick Schuss, Niklas Schäfer, Ulrich Herrlinger, Hartmut Vatter, Asadeh Lakghomi, Matthias Schneider
Cancers, 2022

Benchmarking Safety Indicators of Surgical Treatment of Brain Metastases Combined with Intraoperative Radiotherapy: Results of Prospective Observational Study with Comparative Matched-Pair Analysis
Motaz Hamed*, Anna-Laura Potthoff*, Julian P. Layer, David Koch, Valeri Borger, Muriel Heimann, Davide Scafa, Gustavo R. Sarria, Jasmin A. Holz, Frederic Carsten Schmeel, Alexander Radbruch, Erdem Güresir, Niklas Schäfer, Patrick Schuss, Stephan Garbe, Frank A. Giordano, Ulrich Herrlinger, Hartmut Vatter, Leonard Christopher Schmeel‡, Matthias Schneider‡; * shared first authorship, ‡ shared senior authorship
Cancers, 2022

Preoperative Metastatic Brain Tumor-Associated Intracerebral Hemorrhage Is Associated With Dismal Prognosis
Motaz Hamed, Niklas Schäfer, Christian Bode, Valeri Borger, Anna-Laura Potthoff, Lars Eichhorn, Frank A. Giordano, Erdem Güresir, Muriel Heimann, Yon-Dschun Ko, Jennifer Landsberg, Felix Lehmann, Alexander Radbruch, Elisa Scharnböck, Christina Schaub, Katjana S. Schwab, Johannes Weller, Ulrich Herrlinger, Hartmut Vatter, Patrick Schuss‡, Matthias Schneider‡; ‡ shared senior authorship
Frontiers in Oncology, 2021

The Surgical Management of Brain Metastases in Non-Small Cell Lung Cancer (NSCLC): Identification of the Early Laboratory and Clinical Determinants of Survival
Matthias Schneider, Niklas Schäfer, Christian Bode, Lars Eichhorn, Frank A. Giordano, Erdem Güresir, Muriel Heimann, Yon-Dschun Ko, Jennifer Landsberg, Felix Lehmann, Alexander Radbruch, Christina Schaub, Katjana S. Schwab, Johannes Weller, Ulrich Herrlinger, Hartmut Vatter, Patrick Schuss
Journal of Clinical Medicine, 2021

Outcome of Elderly Patients With Surgically Treated Brain Metastases
Muriel Heimann, Niklas Schäfer, Christian Bode, Valeri Borger, Lars Eichhorn, Frank A. Giordano, Erdem Güresir, Andreas H. Jacobs, Yon-Dschun Ko, Jennifer Landsberg, Felix Lehmann, Alexander Radbruch, Christina Schaub, Katjana S. Schwab, Johannes Weller, Ulrich Herrlinger, Hartmut Vatter, Patrick Schuss‡, Matthias Schneider‡; ‡ shared senior authorship
Frontiers in Oncology, 2021

Combined Assessment of Preoperative Frailty and Sarcopenia Allows the Prediction of Overall Survival in Patients with Lung Cancer (NSCLC) and Surgically Treated Brain Metastasis
Inja Ilic*, Anton Faron*, Muriel Heimann, Anna-Laura Potthoff, Niklas Schäfer, Christian Bode, Valeri Borger, Lars Eichhorn, Frank A. Giordano, Erdem Güresir, Andreas H. Jacobs, Yon-Dschun Ko, Jennifer Landsberg, Felix Lehmann, Alexander Radbruch, Ulrich Herrlinger, Hartmut Vatter, Patrick Schuss ‡, Matthias Schneider ‡; *shared first authorship, ‡ shared senior authorship
Cancers, 2021

The Impact of Prolonged Mechanical Ventilation on Overall Survival in Patients With Surgically Treated Brain Metastases
Patrick Schuss, Niklas Schäfer, Christian Bode, Valeri Borger, Lars Eichhorn, Frank A. Giordano, Erdem Güresir, Muriel Heimann, Yon-Dschun Ko, Jennifer Landsberg, Felix Lehmann, Anna-Laura Potthoff, Alexander Radbruch, Christina Schaub, Katjana S. Schwab, Johannes Weller, Hartmut Vatter, Ulrich Herrlinger, Matthias Schneider
Frontiers in Oncology, 2021

Prognostic Value of Preoperative Inflammatory Markers in Melanoma Patients with Brain Metastases
Matthias Schneider, Niklas Schäfer, Christian Bode, Valeri Borger, Lars Eichhorn, Frank A. Giordano, Erdem Güresir, Muriel Heimann, Yon-Dschun Ko, Felix Lehmann, Anna-Laura Potthoff, Alexander Radbruch, Christina Schaub, Katjana S. Schwab, Johannes Weller, Hartmut Vatter, Ulrich Herrlinger, Jennifer Landsberg, Patrick Schuss
Journal of Clinical Medicine, 2021

Tumor‐associated epilepsy in patients with brain metastases: necrosis‐to‐tumor ratio forecasts postoperative seizure freedom
Majd Bahna, Muriel Heimann, Christian Bode, Valeri Borger, Lars Eichhorn, Erdem Güresir, Motaz Hamed, Ulrich Herrlinger, Yon‐Dschun Ko, Felix Lehmann, Anna‐Laura Potthoff, Alexander Radbruch, Christina Schaub, Rainer Surges, Johannes Weller, Hartmut Vatter, Niklas Schäfer, Matthias Schneider ‡, Patrick Schuss ‡; ‡ shared senior authorship
Neurosurgical Review, 2021

Comorbidity Burden and Presence of Multiple Intracranial Lesions Are Associated with Adverse Events after Surgical Treatment of Patients with Brain Metastases
Matthias Schneider, Muriel Heimann, Christina Schaub, Lars Eichhorn, Anna-Laura Potthoff, Frank A. Giordano, Erdem Güresir, Yon-Dschun Ko, Jennifer Landsberg, Felix Lehmann, Alexander Radbruch, Katjana S. Schwab, Leonie Weinhold, Johannes Weller, Christian Wispel, Ulrich Herrlinger, Hartmut Vatter, Niklas Schäfer, Patrick Schuss
Cancers, 2020

Epilepsy surgery

Temporal lobe epilepsy surgery: Piriform cortex resection impacts seizure control in the long-term
Valeri Borger, Motaz Hamed, Majd Bahna, Áttila Rácz, Inja Ilic, Anna-Laura Potthoff, Tobias Baumgartner, Theodor Rüber, Albert Becker, Alexander Radbruch, Florian Mormann, Rainer Surges, Hartmut Vatter, Matthias Schneider
Annals of Clinical and Translational Neurology, 2022

Resection of piriform cortex predicts seizure freedom in temporal lobe epilepsy
Valeri Borger*, Matthias Schneider*, Julia Taube, Anna-Laura Potthoff, Vera C. Keil, Motaz Hamed, Gülsah Aydin, Inja Ilic, László Solymosi, Christian E. Elger, Erdem Güresir , Rolf Fimmers, Patrick Schuss, Christoph Helmstaedter, Rainer Surges, Hartmut Vatter; *shared first authorship
Annals of Clinical and Translational Neurology, 2021