Publikationen

2012

Alvarez-Baron E., Michel K., Mittelstaedt T., Opitz T., Schmitz F., Beck H., Dietrich D., Becker A.J., Schoch S. RIM3 and RIM4 are key regulators of neuronal arborization. J.Neurosci in press

van Loo KM, Schaub C, Pernhorst K, Yaari Y, Beck H, Schoch S & Becker AJ. Transcriptional regulation of T-type calcium channel CaV3.2: bi-directionality by early growth response 1 (Egr1) and repressor element 1 (RE-1) protein-silencing transcription factor (REST). J Biol Chem 287, 15489-15501 (2012).

Pitsch J, Opitz T, Borm V, Woitecki A, Staniek M, Beck H, Becker AJ & Schoch S. The Presynaptic Active Zone Protein RIM1alpha Controls Epileptogenesis following Status Epilepticus. The Journal of neuroscience : the official journal of the Society for Neuroscience 32, 12384-12395 (2012).

Hildenbrand S, Schoch S, von Lehe M, Surges R & Muller CE. Tritium-Labeled Brivaracetam with High Specific Activity: Preparation, Characterization and Application in Human Brain Samples. ChemMedChem (2012).

Helmstaedter C, Mihov Y, Toliat MR, Thiele H, Nuernberg P, Schoch S, Surges R, Elger CE, Kunz WS & Hurlemann R. Genetic variation in dopaminergic activity is associated with the risk for psychiatric side effects of levetiracetam. Epilepsia (2012).

Erdmann E, Rupprecht V, Matthews E, Kukley M, Schoch S & Dietrich D. Depression of Release by mGluR8 Alters Ca2+ Dependence of Release Machinery. Cereb Cortex 22, 1498-1509 (2012).

Surges R., Schoch S., Elger C.E. (2012). Synaptisches Vesikelprotein 2A: Beteiligung an epilepsieassoziierten Prozessen und Interaktionen mit Antikonvulsiva. Zeitschrift für Epileptlogie. Epub 12.06.2012

2011

Zürner M, Mittelstaedt T, tom Dieck S, Becker A & Schoch S. Analyses of the spatiotemporal expression and subcellular localization of liprin-alpha proteins. J Comp Neurol 519, 3019-3039 (2011).

Pernhorst K, Raabe A, Niehusmann P, van Loo KM, Grote A, Hoffmann P, Cichon S, Sander T, Schoch S & Becker AJ. Promoter variants determine gamma-aminobutyric acid homeostasis-related gene transcription in human epileptic hippocampi. J Neuropathol Exp Neurol 70, 1080-1088 (2011).

2010

Niehusmann P, Mittelstaedt T, Bien CG, Drexler JF, Grote A, Schoch S & Becker AJ. Presence of human herpes virus 6 DNA exclusively in temporal lobe epilepsy brain tissue of patients with history of encephalitis. Epilepsia 51, 2478-2483 (2010).

Mittelstaedt T, Alvarez-Baron E & Schoch S. RIM proteins and their role in synapse function. Biol Chem 391, 599-606 (2010).

2009

Zürner M & Schoch S. The mouse and human Liprin-alpha family of scaffolding proteins: genomic organization, expression profiling and regulation by alternative splicing. Genomics 93, 243-253 (2009).

Mittelsteadt T, Seifert G, Alvarez-Baron E, Steinhauser C, Becker AJ & Schoch S. Differential mRNA expression patterns of the synaptotagmin gene family in the rodent brain. J Comp Neurol 512, 514-528 (2009).

Lugnier C, Majores M, Fassunke J, Pernhorst K, Niehusmann P, Simon M, Nellist M, Schoch S & Becker A. Hamartin variants that are frequent in focal dysplasias and cortical tubers have reduced tuberin binding and aberrant subcellular distribution in vitro. J Neuropathol Exp Neurol 68, 1136-1146 (2009).

Schoch S., Zürner M., Mittelstaedt, T. ERCs, Liprins and RIM-BPs. In: Squire LR (ed.) Encyclopedia of Neuroscience 2009, volume 5, 487-493. Oxford: Academic Press.

2008

Fassunke J, Majores M, Tresch A, Niehusmann P, Grote A, Schoch S & Becker AJ. Array analysis of epilepsy-associated gangliogliomas reveals expression patterns related to aberrant development of neuronal precursors. Brain 131, 3034-3050 (2008).

Becker AJ, Pitsch J, Sochivko D, Opitz T, Staniek M, Chen CC, Campbell KP, Schoch S, Yaari Y & Beck H. Transcriptional upregulation of Cav3.2 mediates epileptogenesis in the pilocarpine model of epilepsy. J Neurosci 28, 13341-13353 (2008).

Alvarez-Baron E, Bien CG, Schramm J, Elger CE, Becker AJ & Schoch S. Autoantibodies to Munc18, cerebral plasma cells and B-lymphocytes in Rasmussen encephalitis. Epilepsy Res 80, 93-97 (2008).

Mittelstaedt, T., Alvarez-Barón, E., Schoch, S. The Cytomatrix of presynaptic active zones: Molecular organization and function. Neuroforum 03/2008

2007

Schick V, Majores M, Engels G, Hartmann W, Elger CE, Schramm J, Schoch S & Becker AJ. Differential Pi3K-pathway activation in cortical tubers and focal cortical dysplasias with balloon cells. Brain Pathol 17, 165-173 (2007).

Pitsch J, Schoch S, Gueler N, Flor PJ, van der Putten H & Becker AJ. Functional role of mGluR1 and mGluR4 in pilocarpine-induced temporal lobe epilepsy. Neurobiol Dis 26, 623-633 (2007).

Mittelstaedt T & Schoch S. Structure and evolution of RIM-BP genes: identification of a novel family member. Gene 403, 70-79 (2007).

Majores M, Schoch S, Lie A & Becker AJ. Molecular neuropathology of temporal lobe epilepsy: complementary approaches in animal models and human disease tissue. Epilepsia 48 Suppl 2, 4-12 (2007).

Kirschstein T, Bauer M, Muller L, Ruschenschmidt C, Reitze M, Becker AJ, Schoch S & Beck H. Loss of metabotropic glutamate receptor-dependent long-term depression via downregulation of mGluR5 after status epilepticus. J Neurosci 27, 7696-7704 (2007).

Atasoy D, Schoch S, Ho A, Nadasy KA, Liu X, Zhang W, Mukherjee K, Nosyreva ED, Fernandez-Chacon R, Missler M, Kavalali ET & Sudhof TC. Deletion of CASK in mice is lethal and impairs synaptic function. Proc Natl Acad Sci U S A 104, 2525-2530 (2007).

2006

Schoch S, Mittelstaedt T, Kaeser PS, Padgett D, Feldmann N, Chevaleyre V, Castillo PE, Hammer RE, Han W, Schmitz F, Lin W & Sudhof TC. Redundant functions of RIM1alpha and RIM2alpha in Ca(2+)-triggered neurotransmitter release. EMBO J 25, 5852-5863 (2006). Schoch S & Gundelfinger ED. Molecular organization of the presynaptic active zone. Cell Tissue Res 326, 379-391 (2006).

2005

Huang YY, Zakharenko SS, Schoch S, Kaeser PS, Janz R, Sudhof TC, Siegelbaum SA & Kandel ER. Genetic evidence for a protein-kinase-A-mediated presynaptic component in NMDA-receptor-dependent forms of long-term synaptic potentiation. Proc Natl Acad Sci U S A 102, 9365-9370 (2005).

2004

Powell CM, Schoch S, Monteggia L, Barrot M, Matos MF, Feldmann N, Sudhof TC & Nestler EJ. The presynaptic active zone protein RIM1alpha is critical for normal learning and memory. Neuron 42, 143-153 (2004).

Deak F, Schoch S, Liu X, Sudhof TC & Kavalali ET. Synaptobrevin is essential for fast synaptic-vesicle endocytosis. Nat Cell Biol 6, 1102-1108 (2004).

Calakos N, Schoch S, Sudhof TC & Malenka RC. Multiple roles for the active zone protein RIM1alpha in late stages of neurotransmitter release. Neuron 42, 889-896 (2004).

2003

Lonart G, Schoch S, Kaeser PS, Larkin CJ, Sudhof TC & Linden DJ. Phosphorylation of RIM1alpha by PKA triggers presynaptic long-term potentiation at cerebellar parallel fiber synapses. Cell 115, 49-60 (2003).

2002

Schoch S, Castillo PE, Jo T, Mukherjee K, Geppert M, Wang Y, Schmitz F, Malenka RC & Sudhof TC. RIM1alpha forms a protein scaffold for regulating neurotransmitter release at the active zone. Nature 415, 321-326 (2002).

Castillo PE, Schoch S, Schmitz F, Sudhof TC & Malenka RC. RIM1alpha is required for presynaptic long-term potentiation. Nature 415, 327-330 (2002).

2001

Schoch S, Deak F, Konigstorfer A, Mozhayeva M, Sara Y, Sudhof TC & Kavalali ET. SNARE function analyzed in synaptobrevin/VAMP knockout mice. Science 294, 1117-1122 (2001).

Schoch S, Cibelli G, Magin A, Steinmuller L & Thiel G. Modular structure of cAMP response element binding protein 2 (CREB2). Neurochem Int 38, 601-608 (2001).

1999

Okamoto M, Schoch S & Sudhof TC. EHSH1/intersectin, a protein that contains EH and SH3 domains and binds to dynamin and SNAP-25. A protein connection between exocytosis and endocytosis? J Biol Chem 274, 18446-18454 (1999).

Cibelli G, Schoch S & Thiel G. Nuclear targeting of cAMP response element binding protein 2 (CREB2). Eur J Cell Biol 78, 642-649 (1999).

1996

Thiel G, Petersohn D & Schoch S. pHIVTATA-CAT, a versatile vector to study transcriptional regulatory elements in mammalian cells. Gene 168, 173-176 (1996).

Schoch S, Cibelli G & Thiel G. Neuron-specific gene expression of synapsin I. Major role of a negative regulatory mechanism. J Biol Chem 271, 3317-3323 (1996).

Cibelli G, Schoch S, Pajunk H, Brand IA & Thiel G. A (G+C)-rich motif in the aldolase C promoter functions as a constitutive transcriptional enhancer element. Eur J Biochem 237, 311-317 (1996).

Cibelli G, Jungling S, Schoch S, Gerdes HH & Thiel G. Identification of a functional cAMP response element in the secretogranin II gene. Eur J Biochem 236, 171-179 (1996).

1995

Petersohn D, Schoch S, Brinkmann DR & Thiel G. The human synapsin II gene promoter. Possible role for the transcription factor zif268/egr-1, polyoma enhancer activator 3, and AP2. J Biol Chem 270, 24361-24369 (1995).

1994

Thiel G, Schoch S & Petersohn D. Regulation of synapsin I gene expression by the zinc finger transcription factor zif268/egr-1. J Biol Chem 269, 15294-15301 (1994)..