Publications

Selected Publications:

For a complete list of publications, see here

1.	Cylicins are a structural component of the sperm calyx being indispensable for male fertility in mice and human. Schneider S, Kovacevic A, Mayer M, Dicke AK, Arévalo L, Koser SA, Hansen JN, Young S, Brenker C, Kliesch S, Wachten D, Kirfel G, Strünker T, Tüttelmann F, Schorle H. Elife. 2023 Nov 28;12:RP86100. doi: 10.7554/eLife.86100. PMID: 38013430 Free PMC article.
2.	Actl7b deficiency leads to mislocalization of LC8 type dynein light chains and disruption of murine spermatogenesis. Merges GE, Arévalo L, Kovacevic A, Lohanadan K, de Rooij DG, Simon C, Jokwitz M, Witke W, Schorle H. Development. 2023 Nov 1;150(21):dev201593. doi: 10.1242/dev.201593. Epub 2023 Oct 27. PMID: 37800308 Free PMC article.
3.	SPAG17 mediates nuclear translocation of protamines during spermiogenesis. Agudo-Rios C, Rogers A, King I, Bhagat V, Nguyen LMT, Córdova-Fletes C, Krapf D, Strauss JF 3rd, Arévalo L, Merges GE, Schorle H, Roldan ERS, Teves ME. Front Cell Dev Biol. 2023 Sep 12;11:1125096. doi: 10.3389/fcell.2023.1125096. eCollection 2023. PMID: 37766963 Free PMC article.
4.	Genome-scale CRISPR screen reveals neddylation to contribute to cisplatin resistance of testicular germ cell tumours. Funke K, Einsfelder U, Hansen A, Arévalo L, Schneider S, Nettersheim D, Stein V, Schorle H. Br J Cancer. 2023 Jun;128(12):2270-2282. doi: 10.1038/s41416-023-02247-5. Epub 2023 Apr 6. PMID: 37024667 Free PMC article.
5.	Myoglobin regulates fatty acid trafficking and lipid metabolism in mammary epithelial cells. Armbruster J, Aboouf MA, Gassmann M, Egert A, Schorle H, Hornung V, Schmidt T, Schmid-Burgk JL, Kristiansen G, Bicker A, Hankeln T, Zhu H, Gorr TA. PLoS One. 2022 Oct 12;17(10):e0275725. doi: 10.1371/journal.pone.0275725. eCollection 2022. PMID: 36223378 Free PMC article.
6.	PFN4 is required for manchette development and acrosome biogenesis during mouse spermiogenesis. Umer N, Phadke S, Shakeri F, Arévalo L, Lohanadan K, Kirfel G, Sylvester M, Buness A, Schorle H. Development. 2022 Aug 15;149(16):dev200499. doi: 10.1242/dev.200499. Epub 2022 Aug 22. PMID: 35950913 Free PMC article.
7.	Protamines: lessons learned from mouse models. Arévalo L, Esther Merges G, Schneider S, Schorle H. Reproduction. 2022 Jul 26;164(3):R57-R74. doi: 10.1530/REP-22-0107. Print 2022 Sep 1. PMID: 35900356 Review.
8.	Loss of the cleaved-protamine 2 domain leads to incomplete histone-to-protamine exchange and infertility in mice. Arévalo L, Merges GE, Schneider S, Oben FE, Neumann IS, Schorle H. PLoS Genet. 2022 Jun 28;18(6):e1010272. doi: 10.1371/journal.pgen.1010272. eCollection 2022 Jun. PMID: 35763544 Free PMC article.
9.	Loss of Prm1 leads to defective chromatin protamination, impaired PRM2 processing, reduced sperm motility and subfertility in male mice. Merges GE, Meier J, Schneider S, Kruse A, Fröbius AC, Kirfel G, Steger K, Arévalo L, Schorle H. Development. 2022 Jun 15;149(12):dev200330. doi: 10.1242/dev.200330. Epub 2022 Jun 20. PMID: 35608054 Free PMC article.
10.	COVID-19 Infection Induce miR-371a-3p Upregulation Resulting in Influence on Male Fertility. Goebel H, Koeditz B, Huerta M, Kameri E, Nestler T, Kamphausen T, Friemann J, Hamdorf M, Ohrmann T, Koehler P, Cornely OA, Montesinos-Rongen M, Nicol D, Schorle H, Boor P, Quaas A, Pallasch C, Heidenreich A, von Brandenstein M. Biomedicines. 2022 Apr 6;10(4):858. doi: 10.3390/biomedicines10040858. PMID: 35453608 Free PMC article.
11.	Transcriptional CDK Inhibitors as Potential Treatment Option for Testicular Germ Cell Tumors. Funke K, Düster R, Wilson PD, Arévalo L, Geyer M, Schorle H. Cancers (Basel). 2022 Mar 26;14(7):1690. doi: 10.3390/cancers14071690. PMID: 35406461 Free PMC article.
12.	Overexpression of Parkin in clear cell renal cell carcinoma decreases tumor aggressiveness by regulating CKS2 levels. Esser LK, Branchi V, Shakeri F, Simon AG, Stephan C, Kristiansen G, Buness A, Schorle H, Toma MI. Int J Oncol. 2022 Feb;60(2):20. doi: 10.3892/ijo.2022.5310. Epub 2022 Jan 21. PMID: 35059737 Free PMC article.
13.	Induction of Rosette-to-Lumen stage embryoids using reprogramming paradigms in ESCs. Langkabel J, Horne A, Bonaguro L, Holsten L, Hesse T, Knaus A, Riedel Y, Becker M, Händler K, Elmzzahi T, Bassler K, Reusch N, Yeghiazarian LH, Pecht T, Saglam A, Ulas T, Aschenbrenner AC, Kaiser F, Kubaczka C, Schultze JL, Schorle H. Nat Commun. 2021 Dec 16;12(1):7322. doi: 10.1038/s41467-021-27586-w. PMID: 34916498 Free PMC article.
14.	Loss of Profilin3 Impairs Spermiogenesis by Affecting Acrosome Biogenesis, Autophagy, Manchette Development and Mitochondrial Organization. Umer N, Arévalo L, Phadke S, Lohanadan K, Kirfel G, Sons D, Sofia D, Witke W, Schorle H. Front Cell Dev Biol. 2021 Nov 4;9:749559. doi: 10.3389/fcell.2021.749559. eCollection 2021. PMID: 34869336 Free PMC article.
15.	The signal transducer CD24 suppresses the germ cell program and promotes an ectodermal rather than mesodermal cell fate in embryonal carcinomas. Skowron MA, Becker TK, Kurz L, Jostes S, Bremmer F, Fronhoffs F, Funke K, Wakileh GA, Müller MR, Burmeister A, Lenz T, Stefanski A, Stühler K, Petzsch P, Köhrer K, Altevogt P, Albers P, Kristiansen G, Schorle H, Nettersheim D. Mol Oncol. 2022 Feb;16(4):982-1008. doi: 10.1002/1878-0261.13066. Epub 2021 Aug 2. PMID: 34293822 Free PMC article.
16.	On the origin of germ cell neoplasia in situ: Dedifferentiation of human adult Sertoli cells in cross talk with seminoma cells in vitro. Fink C, Baal N, Wilhelm J, Sarode P, Weigel R, Schumacher V, Nettersheim D, Schorle H, Schröck C, Bergmann M, Kliesch S, Kressin M, Savai R. Neoplasia. 2021 Jul;23(7):731-742. doi: 10.1016/j.neo.2021.05.008. Epub 2021 Jun 18. PMID: 34153645 Free PMC article.
17.	TRIM71 Deficiency Causes Germ Cell Loss During Mouse Embryogenesis and Is Associated With Human Male Infertility. Torres-Fernández LA, Emich J, Port Y, Mitschka S, Wöste M, Schneider S, Fietz D, Oud MS, Di Persio S, Neuhaus N, Kliesch S, Hölzel M, Schorle H, Friedrich C, Tüttelmann F, Kolanus W. Front Cell Dev Biol. 2021 May 13;9:658966. doi: 10.3389/fcell.2021.658966. eCollection 2021. PMID: 34055789 Free PMC article.
18.	Filamin A Orchestrates Cytoskeletal Structure, Cell Migration and Stem Cell Characteristics in Human Seminoma TCam-2 Cells. Welter H, Herrmann C, Fröhlich T, Flenkenthaler F, Eubler K, Schorle H, Nettersheim D, Mayerhofer A, Müller-Taubenberger A. Cells. 2020 Nov 30;9(12):2563. doi: 10.3390/cells9122563. PMID: 33266100 Free PMC article.
19.	Cultivation of Clear Cell Renal Cell Carcinoma Patient-Derived Organoids in an Air-Liquid Interface System as a Tool for Studying Individualized Therapy. Esser LK, Branchi V, Leonardelli S, Pelusi N, Simon AG, Klümper N, Ellinger J, Hauser S, Gonzalez-Carmona MA, Ritter M, Kristiansen G, Schorle H, Hölzel M, Toma MI. Front Oncol. 2020 Sep 22;10:1775. doi: 10.3389/fonc.2020.01775. eCollection 2020. PMID: 33072556 Free PMC article.
20.	Cultivation of Testicular Germ Cell Cancer Cell Lines and Establishment of Gene-Edited Subclones Using CRISPR/Cas9. Jostes S, Nettersheim D, Schneider S, Schorle H. Methods Mol Biol. 2021;2195:85-97. doi: 10.1007/978-1-0716-0860-9_7. PMID: 32852759
21.	Persistent Human KIT Receptor Signaling Disposes Murine Placenta to Premature Differentiation Resulting in Severely Disrupted Placental Structure and Functionality. Kaiser F, Hartweg J, Jansky S, Pelusi N, Kubaczka C, Sharma N, Nitsche D, Langkabel J, Schorle H. Int J Mol Sci. 2020 Jul 31;21(15):5503. doi: 10.3390/ijms21155503. PMID: 32752102 Free PMC article.
22.	Protamine-2 Deficiency Initiates a Reactive Oxygen Species (ROS)-Mediated Destruction Cascade during Epididymal Sperm Maturation in Mice. Schneider S, Shakeri F, Trötschel C, Arévalo L, Kruse A, Buness A, Poetsch A, Steger K, Schorle H. Cells. 2020 Jul 27;9(8):1789. doi: 10.3390/cells9081789. PMID: 32727081 Free PMC article.
23.	Targeting EpCAM by a Bispecific Trifunctional Antibody Exerts Profound Cytotoxic Efficacy in Germ Cell Tumor Cell Lines. Schönberger S, Kraft D, Nettersheim D, Schorle H, Casati A, Craveiro RB, Mohseni MM, Calaminus G, Dilloo D. Cancers (Basel). 2020 May 19;12(5):1279. doi: 10.3390/cancers12051279. PMID: 32438548 Free PMC article.
24.	Choice of factors and medium impinge on success of ESC to TSC conversion. Kaiser F, Kubaczka C, Graf M, Langer N, Langkabel J, Arévalo L, Schorle H. Placenta. 2020 Jan 15;90:128-137. doi: 10.1016/j.placenta.2019.12.017. Epub 2019 Dec 23. PMID: 32056544
25.	Mammalian germ cells are determined after PGC colonization of the nascent gonad. Nicholls PK, Schorle H, Naqvi S, Hu YC, Fan Y, Carmell MA, Dobrinski I, Watson AL, Carlson DF, Fahrenkrug SC, Page DC. Proc Natl Acad Sci U S A. 2019 Dec 17;116(51):25677-25687. doi: 10.1073/pnas.1910733116. Epub 2019 Nov 21. PMID: 31754036 Free PMC article.
26.	Unique and redundant roles of SOX2 and SOX17 in regulating the germ cell tumor fate. Jostes SV, Fellermeyer M, Arévalo L, Merges GE, Kristiansen G, Nettersheim D, Schorle H. Int J Cancer. 2020 Mar 15;146(6):1592-1605. doi: 10.1002/ijc.32714. Epub 2019 Nov 1. PMID: 31583686
27.	TCam-2 Cells Deficient for SOX2 and FOXA2 Are Blocked in Differentiation and Maintain a Seminoma-Like Cell Fate In Vivo. Nettersheim D, Vadder S, Jostes S, Heimsoeth A, Schorle H. Cancers (Basel). 2019 May 25;11(5):728. doi: 10.3390/cancers11050728. PMID: 31130628 Free PMC article.
28.	Human sFLT1 Leads to Severe Changes in Placental Differentiation and Vascularization in a Transgenic hsFLT1/rtTA FGR Mouse Model. Vogtmann R, Kühnel E, Dicke N, Verkaik-Schakel RN, Plösch T, Schorle H, Stojanovska V, Herse F, Köninger A, Kimmig R, Winterhager E, Gellhaus A. Front Endocrinol (Lausanne). 2019 Mar 21;10:165. doi: 10.3389/fendo.2019.00165. eCollection 2019. PMID: 30949132 Free PMC article.
29.	N6-Methyladenosine detected in RNA of testicular germ cell tumors is controlled by METTL3, ALKBH5, YTHDC1/F1/F2, and HNRNPC as writers, erasers, and readers. Nettersheim D, Berger D, Jostes S, Kristiansen G, Lochnit G, Schorle H. Andrology. 2019 Jul;7(4):498-506. doi: 10.1111/andr.12612. Epub 2019 Mar 23. PMID: 30903744
30.	Epigenetic drugs and their molecular targets in testicular germ cell tumours. Jostes S, Nettersheim D, Schorle H. Nat Rev Urol. 2019 Apr;16(4):245-259. doi: 10.1038/s41585-019-0154-x. PMID: 30765888 Review.
31.	Deciphering the molecular effects of romidepsin on germ cell tumours: DHRS2 is involved in cell cycle arrest but not apoptosis or induction of romidepsin effectors. Nettersheim D, Berger D, Jostes S, Skowron M, Schorle H. J Cell Mol Med. 2019 Jan;23(1):670-679. doi: 10.1111/jcmm.13971. Epub 2018 Nov 20. PMID: 30460772 Free PMC article.
32.	Placental insufficiency contributes to fatty acid metabolism alterations in aged female mouse offspring. Stojanovska V, Sharma N, Dijkstra DJ, Scherjon SA, Jäger A, Schorle H, Plösch T. Am J Physiol Regul Integr Comp Physiol. 2018 Dec 1;315(6):R1107-R1114. doi: 10.1152/ajpregu.00420.2017. Epub 2018 Sep 12. PMID: 30207754
33.	Prospective Isolation of Poised iPSC Intermediates Reveals Principles of Cellular Reprogramming. Schwarz BA, Cetinbas M, Clement K, Walsh RM, Cheloufi S, Gu H, Langkabel J, Kamiya A, Schorle H, Meissner A, Sadreyev RI, Hochedlinger K. Cell Stem Cell. 2018 Aug 2;23(2):289-305.e5. doi: 10.1016/j.stem.2018.06.013. Epub 2018 Jul 12. PMID: 30017590 Free PMC article.
34.	Signals and transcription factors for specification of human germ cells. Jostes S, Schorle H. Stem Cell Investig. 2018 Apr 29;5:13. doi: 10.21037/sci.2018.04.01. eCollection 2018. PMID: 29782557 Free PMC article. No abstract available.
35.	Brentuximab vedotin exerts profound antiproliferative and pro-apoptotic efficacy in CD30-positive as well as cocultured CD30-negative germ cell tumour cell lines. Schönberger S, van Beekum C, Götz B, Nettersheim D, Schorle H, Schneider DT, Casati A, Craveiro RB, Calaminus G, Dilloo D. J Cell Mol Med. 2018 Jan;22(1):568-575. doi: 10.1111/jcmm.13344. Epub 2017 Sep 22. PMID: 28941150 Free PMC article.
36.	MAPK Signaling and Inflammation Link Melanoma Phenotype Switching to Induction of CD73 during Immunotherapy. Reinhardt J, Landsberg J, Schmid-Burgk JL, Ramis BB, Bald T, Glodde N, Lopez-Ramos D, Young A, Ngiow SF, Nettersheim D, Schorle H, Quast T, Kolanus W, Schadendorf D, Long GV, Madore J, Scolyer RA, Ribas A, Smyth MJ, Tumeh PC, Tüting T, Hölzel M. Cancer Res. 2017 Sep 1;77(17):4697-4709. doi: 10.1158/0008-5472.CAN-17-0395. Epub 2017 Jun 26. PMID: 28652246
37.	The plasticity of germ cell cancers and its dependence on the cellular microenvironment. Nettersheim D, Schorle H. J Cell Mol Med. 2017 Aug;21(8):1463-1467. doi: 10.1111/jcmm.13082. Epub 2017 Feb 28. PMID: 28244655 Free PMC article. Review.
38.	The spleen microenvironment influences disease transformation in a mouse model of KIT^D816V-dependent myeloproliferative neoplasm. Pelusi N, Kosanke M, Riedt T, Rösseler C, Seré K, Li J, Gütgemann I, Zenke M, Janzen V, Schorle H. Sci Rep. 2017 Jan 27;7:41427. doi: 10.1038/srep41427. PMID: 28128288 Free PMC article.
39.	Breaking the first lineage barrier - many roads to trophoblast stem cell fate. Kubaczka C, Kaiser F, Schorle H. Placenta. 2017 Dec;60 Suppl 1:S52-S56. doi: 10.1016/j.placenta.2016.12.025. Epub 2016 Dec 23. PMID: 28043657 Review.
40.	The bromodomain inhibitor JQ1 triggers growth arrest and apoptosis in testicular germ cell tumours in vitro and in vivo. Jostes S, Nettersheim D, Fellermeyer M, Schneider S, Hafezi F, Honecker F, Schumacher V, Geyer M, Kristiansen G, Schorle H. J Cell Mol Med. 2017 Jul;21(7):1300-1314. doi: 10.1111/jcmm.13059. Epub 2016 Dec 27. PMID: 28026145 Free PMC article.
41.	Abrogation of Gap Junctional Communication in ES Cells Results in a Disruption of Primitive Endoderm Formation in Embryoid Bodies. Wörsdörfer P, Bosen F, Gebhardt M, Russ N, Zimmermann K, Komla Kessie D, Sekaran T, Egert A, Ergün S, Schorle H, Pfeifer A, Edenhofer F, Willecke K. Stem Cells. 2017 Apr;35(4):859-871. doi: 10.1002/stem.2545. Epub 2016 Dec 20. PMID: 27870307
42.	Re-visiting the Protamine-2 locus: deletion, but not haploinsufficiency, renders male mice infertile. Schneider S, Balbach M, Jan F Jikeli, Fietz D, Nettersheim D, Jostes S, Schmidt R, Kressin M, Bergmann M, Wachten D, Steger K, Schorle H. Sci Rep. 2016 Nov 11;6:36764. doi: 10.1038/srep36764. PMID: 27833122 Free PMC article.
43.	AP2γ controls adult hippocampal neurogenesis and modulates cognitive, but not anxiety or depressive-like behavior. Mateus-Pinheiro A, Alves ND, Patrício P, Machado-Santos AR, Loureiro-Campos E, Silva JM, Sardinha VM, Reis J, Schorle H, Oliveira JF, Ninkovic J, Sousa N, Pinto L. Mol Psychiatry. 2017 Dec;22(12):1725-1734. doi: 10.1038/mp.2016.169. Epub 2016 Oct 25. PMID: 27777416
44.	Overexpression of histone demethylase Fbxl10 leads to enhanced migration in mouse embryonic fibroblasts. Rohde M, Sievers E, Janzer A, Willmann D, Egert A, Schorle H, Schüle R, Kirfel J. Exp Cell Res. 2016 Nov 1;348(2):123-131. doi: 10.1016/j.yexcr.2016.08.026. Epub 2016 Sep 17. PMID: 27646113
45.	Xenografting of Cancer Cell Lines for In Vivo Screening of the Therapeutic Potential of HDAC Inhibitors. Nettersheim D, Jostes S, Schorle H. Methods Mol Biol. 2017;1510:211-215. doi: 10.1007/978-1-4939-6527-4_15. PMID: 27761823
46.	A signaling cascade including ARID1A, GADD45B and DUSP1 induces apoptosis and affects the cell cycle of germ cell cancers after romidepsin treatment. Nettersheim D, Jostes S, Fabry M, Honecker F, Schumacher V, Kirfel J, Kristiansen G, Schorle H. Oncotarget. 2016 Nov 15;7(46):74931-74946. doi: 10.18632/oncotarget.11647. PMID: 27572311 Free PMC article.
47.	Elucidating human male germ cell development by studying germ cell cancer. Nettersheim D, Jostes S, Schneider S, Schorle H. Reproduction. 2016 Oct;152(4):R101-13. doi: 10.1530/REP-16-0114. PMID: 27512122 Review.
48.	Protocol for the Direct Conversion of Murine Embryonic Fibroblasts into Trophoblast Stem Cells. Kubaczka C, Schorle H. J Vis Exp. 2016 Jul 25;(113):54277. doi: 10.3791/54277. PMID: 27500445 Free PMC article.
49.	The cancer/testis-antigen PRAME supports the pluripotency network and represses somatic and germ cell differentiation programs in seminomas. Nettersheim D, Arndt I, Sharma R, Riesenberg S, Jostes S, Schneider S, Hölzel M, Kristiansen G, Schorle H. Br J Cancer. 2016 Aug 9;115(4):454-64. doi: 10.1038/bjc.2016.187. Epub 2016 Jul 21. PMID: 27441500 Free PMC article.
50.	SOX2 is essential for in vivo reprogramming of seminoma-like TCam-2 cells to an embryonal carcinoma-like fate. Nettersheim D, Heimsoeth A, Jostes S, Schneider S, Fellermeyer M, Hofmann A, Schorle H. Oncotarget. 2016 Jul 26;7(30):47095-47110. doi: 10.18632/oncotarget.9903. PMID: 27283990 Free PMC article.
51.	Tpbpa-Cre-mediated deletion of TFAP2C leads to deregulation of Cdkn1a, Akt1 and the ERK pathway, causing placental growth arrest. Sharma N, Kubaczka C, Kaiser S, Nettersheim D, Mughal SS, Riesenberg S, Hölzel M, Winterhager E, Schorle H. Development. 2016 Mar 1;143(5):787-98. doi: 10.1242/dev.128553. Epub 2016 Jan 25. PMID: 26811378
52.	Direct Induction of Trophoblast Stem Cells from Murine Fibroblasts. Kubaczka C, Senner CE, Cierlitza M, Araúzo-Bravo MJ, Kuckenberg P, Peitz M, Hemberger M, Schorle H. Cell Stem Cell. 2015 Nov 5;17(5):557-68. doi: 10.1016/j.stem.2015.08.005. Epub 2015 Sep 24. PMID: 26412560
53.	BMP Inhibition in Seminomas Initiates Acquisition of Pluripotency via NODAL Signaling Resulting in Reprogramming to an Embryonal Carcinoma. Nettersheim D, Jostes S, Sharma R, Schneider S, Hofmann A, Ferreira HJ, Hoffmann P, Kristiansen G, Esteller MB, Schorle H. PLoS Genet. 2015 Jul 30;11(7):e1005415. doi: 10.1371/journal.pgen.1005415. eCollection 2015 Jul. PMID: 26226633 Free PMC article.
54.	Reduced Gene Dosage of Tfap2c Impairs Trophoblast Lineage Differentiation and Alters Maternal Blood Spaces in the Mouse Placenta. Kaiser S, Koch Y, Kühnel E, Sharma N, Gellhaus A, Kuckenberg P, Schorle H, Winterhager E. Biol Reprod. 2015 Aug;93(2):31. doi: 10.1095/biolreprod.114.126474. Epub 2015 Jun 10. PMID: 26063869
55.	Co-existence of intact stemness and priming of neural differentiation programs in mES cells lacking Trim71. Mitschka S, Ulas T, Goller T, Schneider K, Egert A, Mertens J, Brüstle O, Schorle H, Beyer M, Klee K, Xue J, Günther P, Bassler K, Schultze JL, Kolanus W. Sci Rep. 2015 Jun 9;5:11126. doi: 10.1038/srep11126. PMID: 26057209 Free PMC article.
56.	Injury-induced decline of intrinsic regenerative ability revealed by quantitative proteomics. Belin S, Nawabi H, Wang C, Tang S, Latremoliere A, Warren P, Schorle H, Uncu C, Woolf CJ, He Z, Steen JA. Neuron. 2015 May 20;86(4):1000-1014. doi: 10.1016/j.neuron.2015.03.060. Epub 2015 Apr 30. PMID: 25937169 Free PMC article.
57.	Reference gene validation for RT-qPCR, a note on different available software packages. De Spiegelaere W, Dern-Wieloch J, Weigel R, Schumacher V, Schorle H, Nettersheim D, Bergmann M, Brehm R, Kliesch S, Vandekerckhove L, Fink C. PLoS One. 2015 Mar 31;10(3):e0122515. doi: 10.1371/journal.pone.0122515. eCollection 2015. PMID: 25825906 Free PMC article.
58.	Kit transduced signals counteract erythroid maturation by MAPK-dependent modulation of erythropoietin signaling and apoptosis induction in mouse fetal liver. Haas N, Riedt T, Labbaf Z, Baßler K, Gergis D, Fröhlich H, Gütgemann I, Janzen V, Schorle H. Cell Death Differ. 2015 May;22(5):790-800. doi: 10.1038/cdd.2014.172. Epub 2014 Oct 17. PMID: 25323585 Free PMC article.
59.	Are testicular mast cells involved in the regulation of germ cells in man? Windschüttl S, Nettersheim D, Schlatt S, Huber A, Welter H, Schwarzer JU, Köhn FM, Schorle H, Mayerhofer A. Andrology. 2014 Jul;2(4):615-22. doi: 10.1111/j.2047-2927.2014.00227.x. Epub 2014 Jun 12. PMID: 24919455
60.	Derivation and maintenance of murine trophoblast stem cells under defined conditions. Kubaczka C, Senner C, Araúzo-Bravo MJ, Sharma N, Kuckenberg P, Becker A, Zimmer A, Brüstle O, Peitz M, Hemberger M, Schorle H. Stem Cell Reports. 2014 Jan 30;2(2):232-42. doi: 10.1016/j.stemcr.2013.12.013. eCollection 2014 Feb 11. PMID: 24527396 Free PMC article.
61.	Analysis of TET expression/activity and 5mC oxidation during normal and malignant germ cell development. Nettersheim D, Heukamp LC, Fronhoffs F, Grewe MJ, Haas N, Waha A, Honecker F, Waha A, Kristiansen G, Schorle H. PLoS One. 2013 Dec 26;8(12):e82881. doi: 10.1371/journal.pone.0082881. eCollection 2013. PMID: 24386123 Free PMC article.
62.	Transcription factor TFAP2C regulates major programs required for murine fetal germ cell maintenance and haploinsufficiency predisposes to teratomas in male mice. Schemmer J, Araúzo-Bravo MJ, Haas N, Schäfer S, Weber SN, Becker A, Eckert D, Zimmer A, Nettersheim D, Schorle H. PLoS One. 2013 Aug 13;8(8):e71113. doi: 10.1371/journal.pone.0071113. eCollection 2013. PMID: 23967156 Free PMC article.
63.	Fetuin-B, a liver-derived plasma protein is essential for fertilization. Dietzel E, Wessling J, Floehr J, Schäfer C, Ensslen S, Denecke B, Rösing B, Neulen J, Veitinger T, Spehr M, Tropartz T, Tolba R, Renné T, Egert A, Schorle H, Gottenbusch Y, Hildebrand A, Yiallouros I, Stöcker W, Weiskirchen R, Jahnen-Dechent W. Dev Cell. 2013 Apr 15;25(1):106-12. doi: 10.1016/j.devcel.2013.03.001. Epub 2013 Apr 4. PMID: 23562279
64.	Valproic acid confers functional pluripotency to human amniotic fluid stem cells in a transgene-free approach. Moschidou D, Mukherjee S, Blundell MP, Drews K, Jones GN, Abdulrazzak H, Nowakowska B, Phoolchund A, Lay K, Ramasamy TS, Cananzi M, Nettersheim D, Sullivan M, Frost J, Moore G, Vermeesch JR, Fisk NM, Thrasher AJ, Atala A, Adjaye J, Schorle H, De Coppi P, Guillot PV. Mol Ther. 2012 Oct;20(10):1953-67. doi: 10.1038/mt.2012.117. Epub 2012 Jul 3. PMID: 22760542 Free PMC article.
65.	Connexin 31 (GJB3) deficiency in mouse trophoblast stem cells alters giant cell differentiation and leads to loss of oxygen sensing. Koch Y, van Fürden B, Kaiser S, Klein D, Kibschull M, Schorle H, Carpinteiro A, Gellhaus A, Winterhager E. Biol Reprod. 2012 Aug 23;87(2):37. doi: 10.1095/biolreprod.111.098079. Print 2012 Aug. PMID: 22623621
66.	The role of transcription factor Tcfap2c/TFAP2C in trophectoderm development. Kuckenberg P, Kubaczka C, Schorle H. Reprod Biomed Online. 2012 Jul;25(1):12-20. doi: 10.1016/j.rbmo.2012.02.015. Epub 2012 Mar 3. PMID: 22560121 Review.
67.	Establishment of a versatile seminoma model indicates cellular plasticity of germ cell tumor cells. Nettersheim D, Westernströer B, Haas N, Leinhaas A, Brüstle O, Schlatt S, Schorle H. Genes Chromosomes Cancer. 2012 Jul;51(7):717-26. doi: 10.1002/gcc.21958. Epub 2012 Apr 5. PMID: 22489004
68.	MYCN and ALKF1174L are sufficient to drive neuroblastoma development from neural crest progenitor cells. Schulte JH, Lindner S, Bohrer A, Maurer J, De Preter K, Lefever S, Heukamp L, Schulte S, Molenaar J, Versteeg R, Thor T, Künkele A, Vandesompele J, Speleman F, Schorle H, Eggert A, Schramm A. Oncogene. 2013 Feb 21;32(8):1059-65. doi: 10.1038/onc.2012.106. Epub 2012 Apr 9. PMID: 22484425
69.	PDGF signalling controls age-dependent proliferation in pancreatic β-cells. Chen H, Gu X, Liu Y, Wang J, Wirt SE, Bottino R, Schorle H, Sage J, Kim SK. Nature. 2011 Oct 12;478(7369):349-55. doi: 10.1038/nature10502. PMID: 21993628 Free PMC article.
70.	The seminoma cell line TCam-2 is sensitive to HDAC inhibitor depsipeptide but tolerates various other chemotherapeutic drugs and loss of NANOG expression. Nettersheim D, Gillis A, Biermann K, Looijenga LH, Schorle H. Genes Chromosomes Cancer. 2011 Dec;50(12):1033-42. doi: 10.1002/gcc.20918. Epub 2011 Aug 24. PMID: 21987446
71.	Lactogenic differentiation of HC11 cells is not accompanied by downregulation of AP-2 transcription factor genes. Jäger R, Pappas L, Schorle H. BMC Res Notes. 2011 Sep 9;4:345. doi: 10.1186/1756-0500-4-345. PMID: 21906301 Free PMC article. No abstract available.
72.	Transgenic overexpression of Tcfap2c/AP-2gamma results in liver failure and intestinal dysplasia. Holl D, Kuckenberg P, Woynecki T, Egert A, Becker A, Huss S, Stabenow D, Zimmer A, Knolle P, Tolba R, Fischer HP, Schorle H. PLoS One. 2011;6(7):e22034. doi: 10.1371/journal.pone.0022034. Epub 2011 Jul 13. PMID: 21779369 Free PMC article.
73.	TGF-β1, EGF and FGF4 synergistically induce differentiation of the seminoma cell line TCam-2 into a cell type resembling mixed non-seminoma. Nettersheim D, Gillis AJ, Looijenga LH, Schorle H. Int J Androl. 2011 Aug;34(4 Pt 2):e189-203. doi: 10.1111/j.1365-2605.2011.01172.x. Epub 2011 Jun 8. PMID: 21649665
74.	The role of BLIMP1 and its putative downstream target TFAP2C in germ cell development and germ cell tumours. Schäfer S, Anschlag J, Nettersheim D, Haas N, Pawig L, Schorle H. Int J Androl. 2011 Aug;34(4 Pt 2):e152-8; discussion e158-9. doi: 10.1111/j.1365-2605.2011.01167.x. Epub 2011 May 12. PMID: 21564135 Review.
75.	Lineage conversion of murine extraembryonic trophoblast stem cells to pluripotent stem cells. Kuckenberg P, Peitz M, Kubaczka C, Becker A, Egert A, Wardelmann E, Zimmer A, Brüstle O, Schorle H. Mol Cell Biol. 2011 Apr;31(8):1748-56. doi: 10.1128/MCB.01047-10. Epub 2011 Feb 7. PMID: 21300784 Free PMC article.
76.	Production of chick embryo extract for the cultivation of murine neural crest stem cells. Pajtler K, Bohrer A, Maurer J, Schorle H, Schramm A, Eggert A, Schulte JH. J Vis Exp. 2010 Nov 27;(45):2380. doi: 10.3791/2380. PMID: 21178955 Free PMC article.
77.	NANOG promoter methylation and expression correlation during normal and malignant human germ cell development. Nettersheim D, Biermann K, Gillis AJ, Steger K, Looijenga LH, Schorle H. Epigenetics. 2011 Jan;6(1):114-22. doi: 10.4161/epi.6.1.13433. Epub 2011 Jan 1. PMID: 20930529 Free PMC article.
78.	Interference with activator protein-2 transcription factors leads to induction of apoptosis and an increase in chemo- and radiation-sensitivity in breast cancer cells. Thewes V, Orso F, Jäger R, Eckert D, Schäfer S, Kirfel G, Garbe S, Taverna D, Schorle H. BMC Cancer. 2010 May 11;10:192. doi: 10.1186/1471-2407-10-192. PMID: 20459791 Free PMC article.
79.	The transcription factor TCFAP2C/AP-2gamma cooperates with CDX2 to maintain trophectoderm formation. Kuckenberg P, Buhl S, Woynecki T, van Fürden B, Tolkunova E, Seiffe F, Moser M, Tomilin A, Winterhager E, Schorle H. Mol Cell Biol. 2010 Jul;30(13):3310-20. doi: 10.1128/MCB.01215-09. Epub 2010 Apr 19. PMID: 20404091 Free PMC article.
80.	Loss of transcription factor AP-2gamma/TFAP2C impairs branching morphogenesis of the murine mammary gland. Jäger R, Schäfer S, Hau-Liersch M, Schorle H. Dev Dyn. 2010 Mar;239(3):1027-33. doi: 10.1002/dvdy.22239. PMID: 20131354
81.	The transcription factor TCFAP2C/AP-2gamma cooperates with CDX2 to maintain trophectoderm formation. Schorle H. J Stem Cells Regen Med. 2010 Oct 23;6(2):89. eCollection 2010. PMID: 24693107 No abstract available.
82.	Critical function of AP-2 gamma/TCFAP2C in mouse embryonic germ cell maintenance. Weber S, Eckert D, Nettersheim D, Gillis AJ, Schäfer S, Kuckenberg P, Ehlermann J, Werling U, Biermann K, Looijenga LH, Schorle H. Biol Reprod. 2010 Jan;82(1):214-23. doi: 10.1095/biolreprod.109.078717. Epub 2009 Sep 23. PMID: 19776388
83.	AP2gamma regulates basal progenitor fate in a region- and layer-specific manner in the developing cortex. Pinto L, Drechsel D, Schmid MT, Ninkovic J, Irmler M, Brill MS, Restani L, Gianfranceschi L, Cerri C, Weber SN, Tarabykin V, Baer K, Guillemot F, Beckers J, Zecevic N, Dehay C, Caleo M, Schorle H, Götz M. Nat Neurosci. 2009 Oct;12(10):1229-37. doi: 10.1038/nn.2399. Epub 2009 Sep 13. PMID: 19749747
84.	AP-2alpha regulates migration of GN-11 neurons via a specific genetic programme involving the Axl receptor tyrosine kinase. Orso F, Jäger R, Calogero RA, Schorle H, Sismondi P, De Bortoli M, Taverna D. BMC Biol. 2009 May 22;7:25. doi: 10.1186/1741-7007-7-25. PMID: 19463168 Free PMC article.
85.	Loss of connexin43-mediated gap junctional coupling in the mesenchyme of limb buds leads to altered expression of morphogens in mice. Dobrowolski R, Hertig G, Lechner H, Wörsdörfer P, Wulf V, Dicke N, Eckert D, Bauer R, Schorle H, Willecke K. Hum Mol Genet. 2009 Aug 1;18(15):2899-911. doi: 10.1093/hmg/ddp227. Epub 2009 May 12. PMID: 19439426
86.	An activating mutation in the PDGF receptor alpha results in embryonic lethality caused by malformation of the vascular system. Kurth P, Moenning A, Jäger R, Beine G, Schorle H. Dev Dyn. 2009 May;238(5):1064-72. doi: 10.1002/dvdy.21939. PMID: 19334281
87.	Autochthonous liver tumors induce systemic T cell tolerance associated with T cell receptor down-modulation. Ney JT, Schmidt T, Kurts C, Zhou Q, Eckert D, Felsher DW, Schorle H, Knolle P, Tüting T, Barchet W, Büttner R, Limmer A, Gütgemann I. Hepatology. 2009 Feb;49(2):471-81. doi: 10.1002/hep.22652. PMID: 19105207
88.	Sustained platelet-derived growth factor receptor alpha signaling in osteoblasts results in craniosynostosis by overactivating the phospholipase C-gamma pathway. Moenning A, Jäger R, Egert A, Kress W, Wardelmann E, Schorle H. Mol Cell Biol. 2009 Feb;29(3):881-91. doi: 10.1128/MCB.00885-08. Epub 2008 Dec 1. PMID: 19047372 Free PMC article.
89.	Expression of BLIMP1/PRMT5 and concurrent histone H2A/H4 arginine 3 dimethylation in fetal germ cells, CIS/IGCNU and germ cell tumors. Eckert D, Biermann K, Nettersheim D, Gillis AJ, Steger K, Jäck HM, Müller AM, Looijenga LH, Schorle H. BMC Dev Biol. 2008 Nov 7;8:106. doi: 10.1186/1471-213X-8-106. PMID: 18992153 Free PMC article.
90.	Lactogenic differentiation of HC11 cells is not accompanied by downregulation of AP-2 transcription factor genes. Jäger R, Pappas L, Schorle H. BMC Res Notes. 2008 Jun 23;1:29. doi: 10.1186/1756-0500-1-29. PMID: 18710545 Free PMC article.
91.	[On the role of transcription factor family AP-2 for development and disease--lessons from mouse models]. Schorle H. Verh Dtsch Ges Pathol. 2007;91:91-7. PMID: 18314601 German.
92.	[Embryonal germ cells and germ cell tumors]. Biermann K, Heukamp LC, Nettersheim D, Steger K, Zhou H, Franke FE, Guetgemann I, Sonnack V, Brehm R, Berg J, Bastian PJ, Müller SC, Wang-Eckert L, Schorle H, Büttner R. Verh Dtsch Ges Pathol. 2007;91:39-48. PMID: 18314594 German.
93.	TCam-2 but not JKT-1 cells resemble seminoma in cell culture. Eckert D, Nettersheim D, Heukamp LC, Kitazawa S, Biermann K, Schorle H. Cell Tissue Res. 2008 Feb;331(2):529-38. doi: 10.1007/s00441-007-0527-y. Epub 2007 Nov 15. PMID: 18008088
94.	Gene expression profiling identifies new biological markers of neoplastic germ cells. Biermann K, Heukamp LC, Steger K, Zhou H, Franke FE, Guetgemann I, Sonnack V, Brehm R, Berg J, Bastian PJ, Müller SC, Wang-Eckert L, Schorle H, Büttner R. Anticancer Res. 2007 Sep-Oct;27(5A):3091-100. PMID: 17970049
95.	c-KIT is frequently mutated in bilateral germ cell tumours and down-regulated during progression from intratubular germ cell neoplasia to seminoma. Biermann K, Göke F, Nettersheim D, Eckert D, Zhou H, Kahl P, Gashaw I, Schorle H, Büttner R. J Pathol. 2007 Nov;213(3):311-8. doi: 10.1002/path.2225. PMID: 17768701
96.	Enhanced purification of cell-permeant Cre and germline transmission after transduction into mouse embryonic stem cells. Peitz M, Jäger R, Patsch C, Jäger A, Egert A, Schorle H, Edenhofer F. Genesis. 2007 Aug;45(8):508-17. doi: 10.1002/dvg.20321. PMID: 17661398
97.	Essential role of ubiquitin-specific protease 8 for receptor tyrosine kinase stability and endocytic trafficking in vivo. Niendorf S, Oksche A, Kisser A, Löhler J, Prinz M, Schorle H, Feller S, Lewitzky M, Horak I, Knobeloch KP. Mol Cell Biol. 2007 Jul;27(13):5029-39. doi: 10.1128/MCB.01566-06. Epub 2007 Apr 23. PMID: 17452457 Free PMC article.
98.	Deficiency in the LIM-only protein Fhl2 impairs skin wound healing. Wixler V, Hirner S, Müller JM, Gullotti L, Will C, Kirfel J, Günther T, Schneider H, Bosserhoff A, Schorle H, Park J, Schüle R, Buettner R. J Cell Biol. 2007 Apr 9;177(1):163-72. doi: 10.1083/jcb.200606043. PMID: 17420295 Free PMC article.
99.	Establishment and controlled differentiation of neural crest stem cell lines using conditional transgenesis. Maurer J, Fuchs S, Jäger R, Kurz B, Sommer L, Schorle H. Differentiation. 2007 Sep;75(7):580-91. doi: 10.1111/j.1432-0436.2007.00164.x. Epub 2007 Mar 23. PMID: 17381545
100.	Diagnostic value of markers M2A, OCT3/4, AP-2gamma, PLAP and c-KIT in the detection of extragonadal seminomas. Biermann K, Klingmüller D, Koch A, Pietsch T, Schorle H, Büttner R, Zhou H. Histopathology. 2006 Sep;49(3):290-7. doi: 10.1111/j.1365-2559.2006.02496.x. PMID: 16918976
101.	Normal embryonic development and cardiac morphogenesis in mice with Wnt1-Cre-mediated deletion of connexin43. Kretz M, Eckardt D, Krüger O, Kim JS, Maurer J, Theis M, van Rijen HV, Schorle H, Willecke K. Genesis. 2006 Jun;44(6):269-76. doi: 10.1002/dvg.20204. PMID: 16703618
102.	The AP-2 family of transcription factors. Eckert D, Buhl S, Weber S, Jäger R, Schorle H. Genome Biol. 2005;6(13):246. doi: 10.1186/gb-2005-6-13-246. Epub 2005 Dec 28. PMID: 16420676 Free PMC article. Review.
103.	Spatial expression of germ cell markers during maturation of human fetal male gonads: an immunohistochemical study. Pauls K, Schorle H, Jeske W, Brehm R, Steger K, Wernert N, Büttner R, Zhou H. Hum Reprod. 2006 Feb;21(2):397-404. doi: 10.1093/humrep/dei325. Epub 2005 Oct 6. PMID: 16210381
104.	Cell-specific deletion of glucosylceramide synthase in brain leads to severe neural defects after birth. Jennemann R, Sandhoff R, Wang S, Kiss E, Gretz N, Zuliani C, Martin-Villalba A, Jäger R, Schorle H, Kenzelmann M, Bonrouhi M, Wiegandt H, Gröne HJ. Proc Natl Acad Sci U S A. 2005 Aug 30;102(35):12459-64. doi: 10.1073/pnas.0500893102. Epub 2005 Aug 18. PMID: 16109770 Free PMC article.
105.	Mice transgenic for NPM-ALK develop non-Hodgkin lymphomas. Jäger R, Hahne J, Jacob A, Egert A, Schenkel J, Wernert N, Schorle H, Wellmann A. Anticancer Res. 2005 Sep-Oct;25(5):3191-6. PMID: 16101126
106.	A mouse model for cystic biliary dysgenesis in autosomal recessive polycystic kidney disease (ARPKD). Moser M, Matthiesen S, Kirfel J, Schorle H, Bergmann C, Senderek J, Rudnik-Schöneborn S, Zerres K, Buettner R. Hepatology. 2005 May;41(5):1113-21. doi: 10.1002/hep.20655. PMID: 15830394
107.	Dual role of AP-2gamma in ErbB-2-induced mammary tumorigenesis. Jäger R, Friedrichs N, Heim I, Büttner R, Schorle H. Breast Cancer Res Treat. 2005 Apr;90(3):273-80. doi: 10.1007/s10549-004-4815-x. PMID: 15830141
108.	Transcription factor AP-2gamma, a novel marker of gonocytes and seminomatous germ cell tumors. Pauls K, Jäger R, Weber S, Wardelmann E, Koch A, Büttner R, Schorle H. Int J Cancer. 2005 Jun 20;115(3):470-7. doi: 10.1002/ijc.20913. PMID: 15700319
109.	Towards dissecting the complexity of the AP-1 (activator protein 1) family. Unal R, Weih F, Schorle H, Herrlich P. Adv Exp Med Biol. 2004;553:331-6. doi: 10.1007/978-0-306-48584-8_25. PMID: 15503467 No abstract available.
110.	Distinct spatial expression patterns of AP-2alpha and AP-2gamma in non-neoplastic human breast and breast cancer. Friedrichs N, Jäger R, Paggen E, Rudlowski C, Merkelbach-Bruse S, Schorle H, Buettner R. Mod Pathol. 2005 Mar;18(3):431-8. doi: 10.1038/modpathol.3800292. PMID: 15467710
111.	Cell type-specific conditional regulation of the c-myc proto-oncogene by combining Cre/loxP recombination and tamoxifen-mediated activation. Jäger R, Maurer J, Jacob A, Schorle H. Genesis. 2004 Mar;38(3):145-50. doi: 10.1002/gene.20014. PMID: 15048812
112.	Starvation response in mouse liver shows strong correlation with life-span-prolonging processes. Bauer M, Hamm AC, Bonaus M, Jacob A, Jaekel J, Schorle H, Pankratz MJ, Katzenberger JD. Physiol Genomics. 2004 Apr 13;17(2):230-44. doi: 10.1152/physiolgenomics.00203.2003. PMID: 14762175
113.	Transcription factor AP-2gamma stimulates proliferation and apoptosis and impairs differentiation in a transgenic model. Jäger R, Werling U, Rimpf S, Jacob A, Schorle H. Mol Cancer Res. 2003 Oct;1(12):921-9. PMID: 14573793
114.	Differential role of p300 and CBP acetyltransferase during myogenesis: p300 acts upstream of MyoD and Myf5. Roth JF, Shikama N, Henzen C, Desbaillets I, Lutz W, Marino S, Wittwer J, Schorle H, Gassmann M, Eckner R. EMBO J. 2003 Oct 1;22(19):5186-96. doi: 10.1093/emboj/cdg473. PMID: 14517256 Free PMC article.
115.	Cloning, expression and characterization of the murine Efemp1, a gene mutated in Doyne-Honeycomb retinal dystrophy. Ehlermann J, Weber S, Pfisterer P, Schorle H. Gene Expr Patterns. 2003 Aug;3(4):441-7. doi: 10.1016/s1567-133x(03)00084-x. PMID: 12915309
116.	Dynamic expression of Krüppel-like factor 4 (Klf4), a target of transcription factor AP-2alpha during murine mid-embryogenesis. Ehlermann J, Pfisterer P, Schorle H. Anat Rec A Discov Mol Cell Evol Biol. 2003 Aug;273(2):677-80. doi: 10.1002/ar.a.10089. PMID: 12845703
117.	Terminal renal failure in mice lacking transcription factor AP-2 beta. Moser M, Dahmen S, Kluge R, Gröne H, Dahmen J, Kunz D, Schorle H, Buettner R. Lab Invest. 2003 Apr;83(4):571-8. doi: 10.1097/01.lab.0000064703.92382.50. PMID: 12695560
118.	Mutation of the SBF2 gene, encoding a novel member of the myotubularin family, in Charcot-Marie-Tooth neuropathy type 4B2/11p15. Senderek J, Bergmann C, Weber S, Ketelsen UP, Schorle H, Rudnik-Schöneborn S, Büttner R, Buchheim E, Zerres K. Hum Mol Genet. 2003 Feb 1;12(3):349-56. doi: 10.1093/hmg/ddg030. PMID: 12554688
119.	[Anthrax. The growing danger]. Schorle H. Pathologe. 2002 May;23(3):167-9. doi: 10.1007/s00292-002-0526-4. PMID: 12089782 German. No abstract available.
120.	Exencephaly in a subset of animals heterozygous for AP-2alpha mutation. Kohlbecker A, Lee AE, Schorle H. Teratology. 2002 May;65(5):213-8. doi: 10.1002/tera.10037. PMID: 11967920
121.	Transcription factor gene AP-2 gamma essential for early murine development. Werling U, Schorle H. Mol Cell Biol. 2002 May;22(9):3149-56. doi: 10.1128/MCB.22.9.3149-3156.2002. PMID: 11940672 Free PMC article.
122.	Conditional inactivation of transcription factor AP-2gamma by using the Cre/loxP recombination system. Werling U, Schorle H. Genesis. 2002 Feb;32(2):127-9. doi: 10.1002/gene.10057. PMID: 11857798 No abstract available.
123.	A subtractive gene expression screen suggests a role of transcription factor AP-2 alpha in control of proliferation and differentiation. Pfisterer P, Ehlermann J, Hegen M, Schorle H. J Biol Chem. 2002 Feb 22;277(8):6637-44. doi: 10.1074/jbc.M108578200. Epub 2001 Dec 10. PMID: 11741941
124.	Mice overexpressing genes from the 22q11 region deleted in velo-cardio-facial syndrome/DiGeorge syndrome have middle and inner ear defects. Funke B, Epstein JA, Kochilas LK, Lu MM, Pandita RK, Liao J, Bauerndistel R, Schüler T, Schorle H, Brown MC, Adams J, Morrow BE. Hum Mol Genet. 2001 Oct 15;10(22):2549-56. doi: 10.1093/hmg/10.22.2549. PMID: 11709542
125.	TBX1 is responsible for cardiovascular defects in velo-cardio-facial/DiGeorge syndrome. Merscher S, Funke B, Epstein JA, Heyer J, Puech A, Lu MM, Xavier RJ, Demay MB, Russell RG, Factor S, Tokooya K, Jore BS, Lopez M, Pandita RK, Lia M, Carrion D, Xu H, Schorle H, Kobler JB, Scambler P, Wynshaw-Boris A, Skoultchi AI, Morrow BE, Kucherlapati R. Cell. 2001 Feb 23;104(4):619-29. doi: 10.1016/s0092-8674(01)00247-1. PMID: 11239417
126.	Regulatory roles of AP-2 transcription factors in vertebrate development, apoptosis and cell-cycle control. Hilger-Eversheim K, Moser M, Schorle H, Buettner R. Gene. 2000 Dec 30;260(1-2):1-12. doi: 10.1016/s0378-1119(00)00454-6. PMID: 11137286 Review.
127.	Expression of Cdcrel-1 (Pnutl1), a gene frequently deleted in velo-cardio-facial syndrome/DiGeorge syndrome. Maldonado-Saldivia J, Funke B, Pandita RK, Schüler T, Morrow BE, Schorle H. Mech Dev. 2000 Aug;96(1):121-4. doi: 10.1016/s0925-4773(00)00370-1. PMID: 10940632
128.	Spatiotemporal expression pattern of keratins in skin of AP-2alpha-deficient mice. Talbot D, Loring J, Schorle H. J Invest Dermatol. 1999 Nov;113(5):816-20. doi: 10.1046/j.1523-1747.1999.00759.x. PMID: 10571739
129.	Transcription factor AP-2 essential for cranial closure and craniofacial development. Schorle H, Meier P, Buchert M, Jaenisch R, Mitchell PJ. Nature. 1996 May 16;381(6579):235-8. doi: 10.1038/381235a0. PMID: 8622765
130.	[Generalized autoimmune diseases in BALB/c mice with a genetically dependent interleukin-2 deficiency]. Löhler J, Sadlack B, Schorle H, Klebb G, Haber H, Horak I. Verh Dtsch Ges Pathol. 1996;80:293-6. PMID: 9065030 German.
131.	Generalized autoimmune disease in interleukin-2-deficient mice is triggered by an uncontrolled activation and proliferation of CD4+ T cells. Sadlack B, Löhler J, Schorle H, Klebb G, Haber H, Sickel E, Noelle RJ, Horak I. Eur J Immunol. 1995 Nov;25(11):3053-9. doi: 10.1002/eji.1830251111. PMID: 7489743
132.	Antiviral immune responses in mice deficient for both interleukin-2 and interleukin-4. Bachmann MF, Schorle H, Kühn R, Müller W, Hengartner H, Zinkernagel RM, Horak I. J Virol. 1995 Aug;69(8):4842-6. doi: 10.1128/JVI.69.8.4842-4846.1995. PMID: 7609051 Free PMC article.
133.	Development and proliferation of lymphocytes in mice deficient for both interleukins-2 and -4. Sadlack B, Kühn R, Schorle H, Rajewsky K, Müller W, Horak I. Eur J Immunol. 1994 Jan;24(1):281-4. doi: 10.1002/eji.1830240144. PMID: 7517363
134.	Immune responses in interleukin-2-deficient mice. Kündig TM, Schorle H, Bachmann MF, Hengartner H, Zinkernagel RM, Horak I. Science. 1993 Nov 12;262(5136):1059-61. doi: 10.1126/science.8235625. PMID: 8235625
135.	Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene. Sadlack B, Merz H, Schorle H, Schimpl A, Feller AC, Horak I. Cell. 1993 Oct 22;75(2):253-61. doi: 10.1016/0092-8674(93)80067-o. PMID: 8402910
136.	Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting. Schorle H, Holtschke T, Hünig T, Schimpl A, Horak I. Nature. 1991 Aug 15;352(6336):621-4. doi: 10.1038/352621a0. PMID: 1830926