Welcome to the Rudolf-Becker-Laboratory!
Bone metastases in hormone depletion independent prostate cancer is the most important cause of death in patients with adenocarcinoma of the prostate. Published and preliminary data from our lab demonstrate that the transmembrane protein neuropilin-2 is involved in the formation of bone metastases as well as therapy resistance. In close collaboration with the Datta lab at the University of Nebraska Medical Center and cooperation partners at Mayo Clinic Foundation, we have already shown that neuropilin-2 induces stress and therapy resistance in prostate cancer by regulating autophagy and mTOR signaling. Indeed, its expression correlates with disease outcome in different types of cancer like prostate, bladder and pancreatic cancer. Neuropilin-2 is a predictive marker for therapy resistance in bladder cancer. Preliminary data from our lab suggest an important role of neuropilin-2 in homing and colonization of the bone as the most important metastatic site of prostate cancer.
Targeting the immune systems is an important avenue in the therapy of cancer in future. Several studies indicate a high expression of neuropilin-2 in tumor-associated immune cell subset. In cooperation with our American colleagues, we showed that macrophage-derived neuropilin-2 is important for disease progression by regulating a process called efferocytosis.
Taking together all these data, targeting neuropilin-2 might be an important strategy to combat cancer. Indeed, we are currently developing ways to utilize neuropilin-2 for detection and therapy of cancer.
Additionally, we are investigating new candidates with the same potential as biomarkers and future targets of therapy by executing next generation sequencing methodology like RNA sequencing of human tissue in cooperation with our partners in nuclear medicine, urology, oncology, and radiation biology. To validate the potential of these candidates, we will use genetically engineered mouse models to model cancer initiation, progression, and therapy.
- In our lab, we investigate the role of neuropilin-2 and its associated signaling pathways.
- In collaboration with our partners around the world, we were involved in research studies showing that neuropilin-2
- is essential for therapy resistance in cancer by regulating autophagy.
- is an important factor for tumor progression by inducing mTORC2 dependent anti-apoptotic pathways.
- plays an important role in cancer progression by regulating tumor-associated macrophages by inducing efferocytosis.
- is important for EGFR trafficking and activation.
- is important for androgen receptor function in prostate cancer.
- is a predictive biomarker for radio-chemotherapy in bladder cancer.
- In our research, we use mouse models, next generation sequencing techniques, and state of the art glycoprotein analysis tools.
Prof. Dr. Michael Muders
The Rudolf-Becker-Foundation was established in 2003 by testamentary decree of Mister Rudolf Becker to support translational prostate cancer research.
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Bases on our research we gathered some interesting links that you are welcome to check out.
Recent studies of our lab demonstrate the significant role of NRP2 in cancer
Muders lab collaborates with aTyr Pharma, San Diego, CA, USA to develop a tissue based companion diagnostic test for future anti-NRP2 therapies.
Our most recent accepted paper (in press) in Bone Research (2-year impact factor 11.508) demonstrates an important role of neuropilin-2 on tumor cells and osteoclasts during prostate cancer bone metastases. This demonstrate that neuropilin-2 might be an interesting target in therapy of metastatic prostate cancer.
Rui-zhi Bao joined our lab as a new PhD student.
Meeting of the German speaking chapter of the Mayo Alunmni Association will take place in September 2021 in Bonn.
The meeting will be postponed to September 2021. The Muders Group will organize the meeting in Bonn next year.