Osteoblast and osteoclast derived neuropilin-2 in the formation of bone metastases
Others and we have already shown that NRP2 is highly expressed in bone cells like osteoclasts and osteoblasts. The function of osteoblast and osteoclast derived NRP2 expression is not clear yet. In this project, we study the role of NRP2 protein expression in these two subsets of bone cells during the formation of prostate cancer bone metastases using state of the art model in vitro and in vivo model systems.